Entity Details

Primary name NR1H4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ96RI1
EntryNameNR1H4_HUMAN
FullNameBile acid receptor
TaxID9606
Evidenceevidence at protein level
Length486
SequenceStatuscomplete
DateCreated2002-05-27
DateModified2021-06-02

Ontological Relatives

GenesNR1H4

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000791 euchromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001080 nitrogen catabolite activation of transcription from RNA polymerase II promoter
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001678 cellular glucose homeostasis
GO:0003700 DNA-binding transcription factor activity
GO:0004879 nuclear receptor activity
GO:0005654 nucleoplasm
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006954 inflammatory response
GO:0007043 cell-cell junction assembly
GO:0007219 Notch signaling pathway
GO:0008206 bile acid metabolic process
GO:0008270 zinc ion binding
GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0010903 negative regulation of very-low-density lipoprotein particle remodeling
GO:0010988 regulation of low-density lipoprotein particle clearance
GO:0015721 bile acid and bile salt transport
GO:0016922 nuclear receptor binding
GO:0030154 cell differentiation
GO:0030522 intracellular receptor signaling pathway
GO:0032052 bile acid binding
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032689 negative regulation of interferon-gamma production
GO:0032692 negative regulation of interleukin-1 production
GO:0032703 negative regulation of interleukin-2 production
GO:0032715 negative regulation of interleukin-6 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032740 positive regulation of interleukin-17 production
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034162 toll-like receptor 9 signaling pathway
GO:0034255 regulation of urea metabolic process
GO:0034971 histone H3-R17 methylation
GO:0035356 cellular triglyceride homeostasis
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0038181 bile acid receptor activity
GO:0038183 bile acid signaling pathway
GO:0038185 intracellular bile acid receptor signaling pathway
GO:0042632 cholesterol homeostasis
GO:0042742 defense response to bacterium
GO:0043066 negative regulation of apoptotic process
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043235 receptor complex
GO:0043565 sequence-specific DNA binding
GO:0045087 innate immune response
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046628 positive regulation of insulin receptor signaling pathway
GO:0046965 retinoid X receptor binding
GO:0050728 negative regulation of inflammatory response
GO:0055089 fatty acid homeostasis
GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0070857 regulation of bile acid biosynthetic process
GO:0071222 cellular response to lipopolysaccharide
GO:0071398 cellular response to fatty acid
GO:0071417 cellular response to organonitrogen compound
GO:0071638 negative regulation of monocyte chemotactic protein-1 production
GO:0090181 regulation of cholesterol metabolic process
GO:1902122 chenodeoxycholic acid binding
GO:1903413 cellular response to bile acid
GO:1904179 positive regulation of adipose tissue development
GO:1905695 positive regulation of phosphatidic acid biosynthetic process
GO:2000213 positive regulation of glutamate metabolic process
GO:2001250 positive regulation of ammonia assimilation cycle

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000536 Nuclear hormone receptor, ligand-binding domainDomainDomain
IPR001628 Zinc finger, nuclear hormone receptor-typeDomainDomain
IPR001723 Nuclear hormone receptorFamilyFamily
IPR001728 Thyroid hormone receptorFamilyFamily
IPR013088 Zinc finger, NHR/GATA-typeFamilyHomologous superfamily
IPR035500 Nuclear hormone receptor-like domain superfamilyFamilyHomologous superfamily
IPR044114 Bile acid receptor, ligand binding domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00132 alpha-Linolenic acidDrugbanksmall molecule
DB01586 Ursodeoxycholic acidDrugbanksmall molecule
DB02509 FarnesolDrugbanksmall molecule
DB02545 FexaramineDrugbanksmall molecule
DB02659 Cholic AcidDrugbanksmall molecule
DB03619 Deoxycholic acidDrugbanksmall molecule
DB04348 Taurocholic acidDrugbanksmall molecule
DB04557 Arachidonic AcidDrugbanksmall molecule
DB05990 Obeticholic acidDrugbanksmall molecule
DB06777 Chenodeoxycholic acidDrugbanksmall molecule
DB08220 (8alpha,10alpha,13alpha,17beta)-17-[(4-hydroxyphenyl)carbonyl]androsta-3,5-diene-3-carboxylic acidDrugbanksmall molecule
DB11605 MyrrhDrugbanksmall molecule

Interactions

28 interactions

InteractorPartnerSourcesPublicationsLink
NR1H4_HUMANSMRD1_HUMANBioGRID, IntAct12917342 details
NR1H4_HUMANGRB2_HUMANIntAct17474147 details
NR1H4_HUMANNCOA1_HUMANBioGRID, DIP, HPRD, UniProt11136553 14684751 14698205 18391212 20338915 details
NR1H4_HUMANSETD7_HUMANUniProt22345554 details
NR1H4_HUMANPRKDC_HUMANBioGRID, UniProt19833092 details
NR1H4_HUMANXRCC6_HUMANBioGRID, UniProt19833092 details
NR1H4_HUMANXRCC5_HUMANBioGRID, UniProt19833092 details
NR1H4_HUMANRXRB_HUMANBioGRID, IntAct26871637 28514442 32296183 details
NR1H4_HUMANRXRG_HUMANBioGRID, HPRD, IntAct15604093 32296183 details
NR1H4_HUMANPRGC1_HUMANBioGRID, HPRD14729567 details
NR1H4_HUMANRXRA_HUMANBioGRID, HPRD19883617 7760852 details
NR1H4_HUMANCASP8_HUMANBioGRID, HPRD11733517 details
NR1H4_HUMANH31_HUMANBioGRID15471871 details
NR1H4_HUMANNCOA6_HUMANBioGRID21330447 details
NR1H4_HUMANEP300_HUMANBioGRID19883617 details
NR1H4_HUMANSIR1_HUMANBioGRID19883617 details
NR1H4_HUMANG3P_HUMANBioGRID, HPRD15604093 details
NR1H4_HUMANNCOR2_HUMANBioGRID, HPRD16219912 details
NR1H4_HUMANSMRD3_HUMANBioGRID, HPRD14701856 details
NR1H4_HUMANESR1_HUMANBioGRID, HPRD, IntAct17333335 25675114 details
NR1H4_HUMANTF65_HUMANI2D21499302 details
NR1H4_HUMANSRBP2_HUMANIntAct24321096 details
NR1H4_HUMANNCOR1_HUMANBioGRID18978041 details
NR1H4_HUMANANM1_HUMANBioGRID15911693 details
NR1H4_HUMANCARM1_HUMANBioGRID15471871 details
NR1H4_HUMANGPS2_HUMANBioGRID17895379 details
NR1H4_HUMANRIR2_HUMANBioGRID22632967 details
NR1H4_HUMANSUMO1_HUMANBioGRID23546875 details