Entity Details

Primary name KIF3B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO15066
EntryNameKIF3B_HUMAN
FullNameKinesin-like protein KIF3B
TaxID9606
Evidenceevidence at protein level
Length747
SequenceStatuscomplete
DateCreated1998-12-15
DateModified2021-06-02

Ontological Relatives

GenesKIF3B

GO terms

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GOName
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0005813 centrosome
GO:0005819 spindle
GO:0005829 cytosol
GO:0005871 kinesin complex
GO:0005873 plus-end kinesin complex
GO:0005874 microtubule
GO:0005929 cilium
GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
GO:0007018 microtubule-based movement
GO:0007052 mitotic spindle organization
GO:0007100 mitotic centrosome separation
GO:0007368 determination of left/right symmetry
GO:0008017 microtubule binding
GO:0008089 anterograde axonal transport
GO:0008574 plus-end-directed microtubule motor activity
GO:0015630 microtubule cytoskeleton
GO:0016020 membrane
GO:0016887 ATP hydrolysis activity
GO:0016939 kinesin II complex
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0030496 midbody
GO:0031267 small GTPase binding
GO:0032467 positive regulation of cytokinesis
GO:0035735 intraciliary transport involved in cilium assembly
GO:0070062 extracellular exosome
GO:0072383 plus-end-directed vesicle transport along microtubule
GO:0090307 mitotic spindle assembly
GO:0097542 ciliary tip
GO:0120170 intraciliary transport particle B binding
GO:1904115 axon cytoplasm

Subcellular Location

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Subcellular Location
Cell projection
Cytoplasm

Domains

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DomainNameCategoryType
IPR001752 Kinesin motor domainDomainDomain
IPR019821 Kinesin motor domain, conserved siteSiteConserved site
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR027640 Kinesin-like proteinFamilyFamily
IPR036961 Kinesin motor domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
618955 OMIMRetinitis pigmentosa 89 (RP89)A form of retinitis pigmentosa, a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. RP89 is an autosomal dominant form associated with features of ciliopathy, including postaxial polydactyly, and renal and hepatic disease. The gene represented in this entry may be involved in disease pathogenesis.

Interactions

28 interactions

InteractorPartnerSourcesPublicationsLink
KIF3B_HUMANLMO4_HUMANBioGRID, HPRD, MINT15231748 details
KIF3B_HUMANRBTN2_HUMANBioGRID, IntAct21988832 details
KIF3B_HUMANARHGA_HUMANbhf-ucl19635168 details
KIF3B_HUMANKIFA3_HUMANbhf-ucl, BioGRID, HPRD, IntAct16298999 26496610 27173435 28514442 9506951 unassigned1312 details
KIF3B_HUMANCLCN5_HUMANIntAct19940036 details
KIF3B_HUMANRAB4A_HUMANBioGRID, HPRD12832475 details
KIF3B_HUMANM3K11_HUMANBioGRID9427749 details
KIF3B_HUMANNED4L_HUMANBioGRID19664597 details
KIF3B_HUMANA4_HUMANBioGRID21244100 21832049 details
KIF3B_HUMANPRC1_HUMANBioGRID30217970 details
KIF3B_HUMANSASH1_HUMANBioGRID30480076 details
KIF3B_HUMANM3K10_HUMANHPRD9427749 details
KIF3B_HUMANKIF3A_HUMANBioGRID, HPRD, IntAct17825299 26496610 27173435 28514442 7559760 unassigned1312 details
KIF3B_HUMANPRS8_HUMANBioGRID, IntAct27173435 unassigned1312 details
KIF3B_HUMANSAV1_HUMANBioGRID, IntAct27173435 unassigned1312 details
KIF3B_HUMANDYRK2_HUMANBioGRID, IntAct27173435 unassigned1312 details
KIF3B_HUMANSTK3_HUMANBioGRID, IntAct27173435 unassigned1312 details
KIF3B_HUMANSTK4_HUMANBioGRID, IntAct27173435 unassigned1312 details
KIF3B_HUMANAKA12_HUMANBioGRID, IntAct27173435 unassigned1312 details
KIF3B_HUMANKIF3C_HUMANBioGRID, IntAct27173435 unassigned1312 details
KIF3B_HUMANNHRF2_HUMANBioGRID, IntAct27173435 unassigned1312 details
KIF3B_HUMANEXOC1_HUMANIntAct31413325 details
KIF3B_HUMANFMR1_HUMANIntAct31413325 details
KIF3B_HUMANRAB5A_HUMANBioGRID12832475 details
KIF3B_HUMANVHL_HUMANBioGRID17825299 details
KIF3B_HUMANRBP2_HUMANBioGRID9733766 details
KIF3B_HUMANMEX3B_HUMANBioGRID29395067 details
KIF3B_HUMANIFT20_HUMANHPRD12821668 details