Entity Details

Primary name PKP2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ99959
EntryNamePKP2_HUMAN
FullNamePlakophilin-2
TaxID9606
Evidenceevidence at protein level
Length881
SequenceStatuscomplete
DateCreated2002-01-23
DateModified2021-06-02

Ontological Relatives

GenesPKP2

GO terms

Show/Hide Table
GOName
GO:0001533 cornified envelope
GO:0002159 desmosome assembly
GO:0002934 desmosome organization
GO:0005080 protein kinase C binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005882 intermediate filament
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005912 adherens junction
GO:0007043 cell-cell junction assembly
GO:0007507 heart development
GO:0010765 positive regulation of sodium ion transport
GO:0014704 intercalated disc
GO:0016021 integral component of membrane
GO:0017080 sodium channel regulator activity
GO:0019215 intermediate filament binding
GO:0030054 cell junction
GO:0030057 desmosome
GO:0031424 keratinization
GO:0044325 transmembrane transporter binding
GO:0045110 intermediate filament bundle assembly
GO:0045294 alpha-catenin binding
GO:0045296 cadherin binding
GO:0048496 maintenance of animal organ identity
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0060090 molecular adaptor activity
GO:0070268 cornification
GO:0072659 protein localization to plasma membrane
GO:0086002 cardiac muscle cell action potential involved in contraction
GO:0086005 ventricular cardiac muscle cell action potential
GO:0086019 cell-cell signaling involved in cardiac conduction
GO:0086064 cell communication by electrical coupling involved in cardiac conduction
GO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication
GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication
GO:0086091 regulation of heart rate by cardiac conduction
GO:0098609 cell-cell adhesion
GO:0098911 regulation of ventricular cardiac muscle cell action potential

Subcellular Location

Show/Hide Table
Subcellular Location
Cell junction
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR000225 ArmadilloRepeatRepeat
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR028435 Plakophilin/Delta cateninFamilyFamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
609040 OMIMArrhythmogenic right ventricular dysplasia, familial, 9 (ARVD9)A congenital heart disease characterized by infiltration of adipose and fibrous tissue into the right ventricle and loss of myocardial cells, resulting in ventricular and supraventricular arrhythmias. The disease is caused by variants affecting the gene represented in this entry.

Interactions

52 interactions

InteractorPartnerSourcesPublicationsLink
PKP2_HUMANMARK3_HUMANBioGRID, HPRD, MINT12941695 details
PKP2_HUMANSMAD9_HUMANBioGRID, HPRD, MINT15231748 details
PKP2_HUMANVIME_HUMANbhf-ucl10852826 details
PKP2_HUMANK2C8_HUMANbhf-ucl10852826 details
PKP2_HUMANK1C14_HUMANbhf-ucl10852826 details
PKP2_HUMANK1C18_HUMANbhf-ucl, BioGRID, HPRD10852826 details
PKP2_HUMANK2C5_HUMANbhf-ucl, BioGRID, HPRD10852826 details
PKP2_HUMANMTUS2_HUMANBioGRID, IntAct25416956 25910212 31515488 32296183 details
PKP2_HUMANNDEL1_HUMANBioGRID, IntAct25416956 25910212 30217970 details
PKP2_HUMANDESP_HUMANBioGRID, HPRD, IntAct11790773 25225338 details
PKP2_HUMANCC125_HUMANBioGRID, IntAct32296183 details
PKP2_HUMANPKHG4_HUMANBioGRID, IntAct32296183 details
PKP2_HUMANACTN3_HUMANBioGRID, IntAct32296183 details
PKP2_HUMANFHL3_HUMANBioGRID, IntAct32296183 details
PKP2_HUMANHOOK2_HUMANBioGRID, IntAct32296183 details
PKP2_HUMANGOGA2_HUMANBioGRID, IntAct32296183 details
PKP2_HUMANMGN2_HUMANBioGRID, IntAct32296183 details
PKP2_HUMANTEKT4_HUMANBioGRID, IntAct32296183 details
PKP2_HUMANCCHCR_HUMANBioGRID, IntAct32296183 details
PKP2_HUMANCC120_HUMANBioGRID, IntAct32296183 details
PKP2_HUMANROP1A_HUMANBioGRID, IntAct32296183 details
PKP2_HUMANK1H1_HUMANBioGRID, IntAct32296183 details
PKP2_HUMANSPTA1_HUMANBioGRID, IntAct32296183 details
PKP2_HUMANRABE1_HUMANBioGRID, IntAct32296183 details
PKP2_HUMANSPN90_HUMANBioGRID, IntAct32296183 details
PKP2_HUMANCARD9_HUMANBioGRID, IntAct32296183 details
PKP2_HUMANGRAP1_HUMANBioGRID, IntAct32296183 details
PKP2_HUMANGT2D1_HUMANBioGRID, IntAct26275350 details
PKP2_HUMANHSPB2_HUMANbhf-ucl, BioGRID26465331 details
PKP2_HUMANARMC8_HUMANBioGRID, IntAct29911972 30482882 details
PKP2_HUMANCTNA3_HUMANIntAct23136403 details
PKP2_HUMANPLAK_HUMANBioGRID, HPRD11790773 details
PKP2_HUMANDSG1_HUMANBioGRID, HPRD11790773 details
PKP2_HUMANDSG2_HUMANBioGRID, HPRD11790773 details
PKP2_HUMANDSC1_HUMANBioGRID, HPRD11790773 details
PKP2_HUMANDSC2_HUMANBioGRID, HPRD11790773 details
PKP2_HUMANRPC1_HUMANBioGRID, HPRD11416169 details
PKP2_HUMANCTNB1_HUMANBioGRID, HPRD11790773 27684187 34079125 details
PKP2_HUMANDMRTB_HUMANBioGRID30217970 details
PKP2_HUMANRBM5_HUMANBioGRID30217970 details
PKP2_HUMANCSKP_HUMANBioGRID30217970 details
PKP2_HUMANKLC4_HUMANBioGRID30217970 details
PKP2_HUMANAKAP9_HUMANBioGRID30217970 details
PKP2_HUMANPIBF1_HUMANBioGRID32296183 details
PKP2_HUMAN1433Z_HUMANMINT12941695 details
PKP2_HUMAN1433S_HUMANBioGRID, MINT15778465 details
PKP2_HUMANFOS_HUMANIntAct20195357 details
PKP2_HUMAN1433T_HUMANBioGRID, IntAct12941695 28514442 details
PKP2_HUMAN1433G_HUMANHPRD, IntAct15324660 28514442 details
PKP2_HUMANTF2B_HUMANBioGRID11416169 details
PKP2_HUMAN1433E_HUMANBioGRID17979178 details
PKP2_HUMANPKP2_HUMANHPRD10852826 details