Entity Details

Primary name S22A2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO15244
EntryNameS22A2_HUMAN
FullNameSolute carrier family 22 member 2
TaxID9606
Evidenceevidence at protein level
Length555
SequenceStatuscomplete
DateCreated2008-02-26
DateModified2021-06-02

Ontological Relatives

GenesSLC22A2

GO terms

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GOName
GO:0005275 amine transmembrane transporter activity
GO:0005326 neurotransmitter transmembrane transporter activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006836 neurotransmitter transport
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007589 body fluid secretion
GO:0008504 monoamine transmembrane transporter activity
GO:0010628 positive regulation of gene expression
GO:0015101 organic cation transmembrane transporter activity
GO:0015179 L-amino acid transmembrane transporter activity
GO:0015214 pyrimidine nucleoside transmembrane transporter activity
GO:0015220 choline transmembrane transporter activity
GO:0015562 efflux transmembrane transporter activity
GO:0015695 organic cation transport
GO:0015837 amine transport
GO:0015871 choline transport
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0019534 toxin transmembrane transporter activity
GO:0042136 neurotransmitter biosynthetic process
GO:0042908 xenobiotic transport
GO:0042910 xenobiotic transmembrane transporter activity
GO:0051610 serotonin uptake
GO:0051615 histamine uptake
GO:0051620 norepinephrine uptake
GO:0061459 L-arginine transmembrane transporter activity
GO:0070062 extracellular exosome
GO:0072530 purine-containing compound transmembrane transport
GO:0089718 amino acid import across plasma membrane
GO:0090494 dopamine uptake
GO:0097638 L-arginine import across plasma membrane
GO:0098793 presynapse
GO:0140115 export across plasma membrane
GO:0150104 transport across blood-brain barrier
GO:1901998 toxin transport
GO:1902475 L-alpha-amino acid transmembrane transport
GO:1990962 xenobiotic transport across blood-brain barrier

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR004749 Organic cation transport protein/SVOPFamilyFamily
IPR005828 Major facilitator, sugar transporter-likeFamilyFamily
IPR005829 Sugar transporter, conserved siteSiteConserved site
IPR020846 Major facilitator superfamily domainDomainDomain
IPR036259 MFS transporter superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00122 CholineDrugbanksmall molecule
DB00152 ThiamineDrugbanksmall molecule
DB00184 NicotineDrugbanksmall molecule
DB00204 DofetilideDrugbanksmall molecule
DB00206 ReserpineDrugbanksmall molecule
DB00264 MetoprololDrugbanksmall molecule
DB00280 DisopyramideDrugbanksmall molecule
DB00331 MetforminDrugbanksmall molecule
DB00345 Aminohippuric acidSwissprotsmall molecule
DB00365 GrepafloxacinDrugbanksmall molecule
DB00368 NorepinephrineDrugbanksmall molecule
DB00396 ProgesteroneDrugbanksmall molecule
DB00413 PramipexoleDrugbanksmall molecule
DB00437 AllopurinolDrugbanksmall molecule
DB00448 LansoprazoleDrugbanksmall molecule
DB00458 ImipramineDrugbanksmall molecule
DB00468 QuinineDrugbanksmall molecule
DB00495 ZidovudineDrugbanksmall molecule
DB00501 CimetidineDrugbanksmall molecule
DB00515 CisplatinDrugbanksmall molecule
DB00526 OxaliplatinSwissprotsmall molecule
DB00536 GuanidineDrugbanksmall molecule
DB00555 LamotrigineDrugbanksmall molecule
DB00571 PropranololDrugbanksmall molecule
DB00594 AmilorideDrugbanksmall molecule
DB00619 ImatinibDrugbanksmall molecule
DB00668 EpinephrineDrugbanksmall molecule
DB00690 FlurazepamDrugbanksmall molecule
DB00709 LamivudineDrugbanksmall molecule
DB00758 ClopidogrelDrugbanksmall molecule
DB00783 EstradiolDrugbanksmall molecule
DB00863 RanitidineDrugbanksmall molecule
DB00907 CocaineDrugbanksmall molecule
DB00908 QuinidineDrugbanksmall molecule
DB00914 PhenforminDrugbanksmall molecule
DB00915 AmantadineDrugbanksmall molecule
DB00917 DinoprostoneDrugbanksmall molecule
DB00925 PhenoxybenzamineDrugbanksmall molecule
DB00927 FamotidineDrugbanksmall molecule
DB00938 SalmeterolDrugbanksmall molecule
DB00988 DopamineDrugbanksmall molecule
DB01018 GuanfacineDrugbanksmall molecule
DB01032 ProbenecidDrugbanksmall molecule
DB01035 ProcainamideDrugbanksmall molecule
DB01043 MemantineDrugbanksmall molecule
DB01075 DiphenhydramineDrugbanksmall molecule
DB01103 QuinacrineDrugbanksmall molecule
DB01114 ChlorpheniramineDrugbanksmall molecule
DB01118 AmiodaroneDrugbanksmall molecule
DB01137 LevofloxacinDrugbanksmall molecule
DB01151 DesipramineDrugbanksmall molecule
DB01156 BupropionDrugbanksmall molecule
DB01160 Dinoprost tromethamineDrugbanksmall molecule
DB01199 TubocurarineDrugbanksmall molecule
DB01273 VareniclineDrugbanksmall molecule
DB01337 PancuroniumDrugbanksmall molecule
DB01580 OxprenololDrugbanksmall molecule
DB04855 DronedaroneDrugbanksmall molecule
DB05294 VandetanibDrugbanksmall molecule
DB05381 HistamineDrugbanksmall molecule
DB05383 PimagedineDrugbanksmall molecule
DB06137 TirbanibulinDrugbanksmall molecule
DB06608 TafenoquineSwissprotsmall molecule
DB06637 DalfampridineDrugbanksmall molecule
DB08837 TetraethylammoniumDrugbanksmall molecule
DB08838 AgmatineDrugbanksmall molecule
DB08839 SerotoninDrugbanksmall molecule
DB08840 N-methylnicotinamideSwissprotsmall molecule
DB08882 LinagliptinDrugbanksmall molecule
DB08930 DolutegravirDrugbanksmall molecule
DB09078 LenvatinibDrugbanksmall molecule
DB09241 Methylene blueDrugbanksmall molecule
DB09343 TipiracilDrugbanksmall molecule
DB09555 Dexchlorpheniramine maleateDrugbanksmall molecule
DB11633 IsavuconazoleDrugbanksmall molecule
DB11652 TucatinibDrugbanksmall molecule
DB11817 BaricitinibDrugbanksmall molecule
DB11837 OsilodrostatDrugbanksmall molecule
DB11901 ApalutamideDrugbanksmall molecule
DB12001 AbemaciclibDrugbanksmall molecule
DB12147 ErdafitinibDrugbanksmall molecule
DB12457 RimegepantDrugbanksmall molecule
DB12598 NafamostatDrugbanksmall molecule
DB13874 EnasidenibDrugbanksmall molecule
DB13946 Testosterone undecanoateDrugbanksmall molecule
DB13952 Estradiol acetateDrugbanksmall molecule
DB13953 Estradiol benzoateDrugbanksmall molecule
DB13954 Estradiol cypionateDrugbanksmall molecule
DB13955 Estradiol dienanthateDrugbanksmall molecule
DB13956 Estradiol valerateDrugbanksmall molecule
DB14006 Choline salicylateDrugbanksmall molecule
DB14754 SolriamfetolDrugbanksmall molecule
DB15102 PemigatinibDrugbanksmall molecule
DB15328 UbrogepantDrugbanksmall molecule

Interactions

45 interactions

InteractorPartnerSourcesPublicationsLink
S22A2_HUMANETV5_HUMANBioGRID, IntAct21988832 details
S22A2_HUMANEXT2_HUMANBioGRID, IntAct21988832 details
S22A2_HUMANTF2B_HUMANBioGRID, IntAct21988832 details
S22A2_HUMANSUMO2_HUMANBioGRID, IntAct21988832 details
S22A2_HUMANHYAL3_HUMANBioGRID, IntAct21988832 details
S22A2_HUMANLSM4_HUMANBioGRID, IntAct21988832 details
S22A2_HUMANCST9L_HUMANBioGRID, IntAct21988832 details
S22A2_HUMANAGO3_HUMANBioGRID, IntAct21988832 details
S22A2_HUMANCCL2_HUMANBioGRID31318583 details
S22A2_HUMANCD63_HUMANBioGRID31318583 details
S22A2_HUMANCD9_HUMANBioGRID31318583 details
S22A2_HUMANNB5R3_HUMANBioGRID31318583 details
S22A2_HUMANFIS1_HUMANBioGRID31318583 details
S22A2_HUMANHNRH3_HUMANBioGRID31318583 details
S22A2_HUMANLAP4A_HUMANBioGRID31318583 details
S22A2_HUMANLAP4B_HUMANBioGRID31318583 details
S22A2_HUMANPDIA6_HUMANBioGRID31318583 details
S22A2_HUMANPDZ1I_HUMANBioGRID31318583 details
S22A2_HUMANSERP1_HUMANBioGRID31318583 details
S22A2_HUMANSPCS1_HUMANBioGRID31318583 details
S22A2_HUMANTM134_HUMANBioGRID31318583 details
S22A2_HUMANT176B_HUMANBioGRID31318583 details
S22A2_HUMANITM2C_HUMANBioGRID31318583 details
S22A2_HUMANCLPT1_HUMANBioGRID31318583 details
S22A2_HUMANDPM2_HUMANBioGRID31318583 details
S22A2_HUMANEF1G_HUMANBioGRID31318583 details
S22A2_HUMANLFG2_HUMANBioGRID31318583 details
S22A2_HUMANATNG_HUMANBioGRID31318583 details
S22A2_HUMANFZD5_HUMANBioGRID31318583 details
S22A2_HUMANHRCT1_HUMANBioGRID31318583 details
S22A2_HUMANKTAP2_HUMANBioGRID31318583 details
S22A2_HUMANLAPM5_HUMANBioGRID31318583 details
S22A2_HUMANPRP8_HUMANBioGRID31318583 details
S22A2_HUMANRPN2_HUMANBioGRID31318583 details
S22A2_HUMANS40A1_HUMANBioGRID31318583 details
S22A2_HUMANS47A2_HUMANBioGRID31318583 details
S22A2_HUMANSTX8_HUMANBioGRID31318583 details
S22A2_HUMANTM147_HUMANBioGRID31318583 details
S22A2_HUMANT161A_HUMANBioGRID31318583 details
S22A2_HUMANTM41B_HUMANBioGRID31318583 details
S22A2_HUMANNCOA3_HUMANBioGRID31318583 details
S22A2_HUMANTREX1_HUMANBioGRID31318583 details
S22A2_HUMANTMX2_HUMANBioGRID31318583 details
S22A2_HUMANVKOR1_HUMANBioGRID31318583 details
S22A2_HUMANOBF1_HUMANHPRD11483518 details