Entity Details

Primary name S39A8_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9C0K1
EntryNameS39A8_HUMAN
FullNameMetal cation symporter ZIP8
TaxID9606
Evidenceevidence at protein level
Length460
SequenceStatuscomplete
DateCreated2007-12-04
DateModified2021-06-02

Ontological Relatives

GenesSLC39A8

GO terms

Show/Hide Table
GOName
GO:0005381 iron ion transmembrane transporter activity
GO:0005384 manganese ion transmembrane transporter activity
GO:0005385 zinc ion transmembrane transporter activity
GO:0005765 lysosomal membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006487 protein N-linked glycosylation
GO:0006525 arginine metabolic process
GO:0006824 cobalt ion transport
GO:0006829 zinc ion transport
GO:0006876 cellular cadmium ion homeostasis
GO:0006882 cellular zinc ion homeostasis
GO:0015086 cadmium ion transmembrane transporter activity
GO:0015087 cobalt ion transmembrane transporter activity
GO:0015106 bicarbonate transmembrane transporter activity
GO:0015296 anion:cation symporter activity
GO:0015701 bicarbonate transport
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0030026 cellular manganese ion homeostasis
GO:0030198 extracellular matrix organization
GO:0031090 organelle membrane
GO:0042391 regulation of membrane potential
GO:0061757 leukocyte adhesion to arterial endothelial cell
GO:0070574 cadmium ion transmembrane transport
GO:0071421 manganese ion transmembrane transport
GO:0071577 zinc ion transmembrane transport
GO:0071578 zinc ion import across plasma membrane
GO:0097079 selenite:proton symporter activity
GO:0097080 plasma membrane selenite transport
GO:0098711 iron ion import across plasma membrane
GO:0140412 zinc:bicarbonate symporter activity
GO:1990079 cartilage homeostasis
GO:1990540 mitochondrial manganese ion transmembrane transport

Subcellular Location

Show/Hide Table
Subcellular Location
Apical cell membrane
Basolateral cell membrane
Cell membrane
Lysosome membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR003689 Zinc/iron permeaseFamilyFamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
S39A8_HUMANPE2R4_HUMANBioGRID, MINT28298427 details