Entity Details

Primary name XRN2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9H0D6
EntryNameXRN2_HUMAN
FullName5'-3' exoribonuclease 2
TaxID9606
Evidenceevidence at protein level
Length950
SequenceStatuscomplete
DateCreated2003-04-23
DateModified2021-06-02

Ontological Relatives

GenesXRN2

GO terms

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GOName
GO:0000175 3'-5'-exoribonuclease activity
GO:0000738 DNA catabolic process, exonucleolytic
GO:0000956 nuclear-transcribed mRNA catabolic process
GO:0001147 transcription termination site sequence-specific DNA binding
GO:0003723 RNA binding
GO:0004518 nuclease activity
GO:0004534 5'-3' exoribonuclease activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0006364 rRNA processing
GO:0006396 RNA processing
GO:0006397 mRNA processing
GO:0006401 RNA catabolic process
GO:0007283 spermatogenesis
GO:0008409 5'-3' exonuclease activity
GO:0016020 membrane
GO:0016070 RNA metabolic process
GO:0016235 aggresome
GO:0021766 hippocampus development
GO:0030182 neuron differentiation
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0060041 retina development in camera-type eye

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR004859 Putative 5-3 exonucleaseDomainDomain
IPR017151 5'-3' exoribonuclease type 2FamilyFamily
IPR027073 5'-3' exoribonucleaseFamilyFamily
IPR041412 Xrn1, helical domainDomainDomain

Diseases

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Interactions

116 interactions

InteractorPartnerSourcesPublicationsLink
XRN2_HUMANLSM3_HUMANBioGRID, HPRD, IntAct15231747 details
XRN2_HUMANEXOSX_HUMANBioGRID, HPRD, IntAct15231747 details
XRN2_HUMANDXO_HUMANBioGRID, HPRD, IntAct15231747 details
XRN2_HUMANEXOS8_HUMANBioGRID, HPRD, IntAct15231747 details
XRN2_HUMANRENT2_HUMANBioGRID, HPRD, IntAct15231747 details
XRN2_HUMANPSA3_HUMANBioGRID, HPRD, IntAct15231747 details
XRN2_HUMANIF6_HUMANBioGRID, HPRD, IntAct15231747 details
XRN2_HUMANEIF3L_HUMANBioGRID, HPRD, IntAct15231747 details
XRN2_HUMANIF5A1_HUMANBioGRID, HPRD, IntAct15231747 details
XRN2_HUMANPARPT_HUMANBioGRID, HPRD, IntAct15231747 details
XRN2_HUMANCOMT_HUMANBioGRID, HPRD, IntAct15231747 details
XRN2_HUMANMOCS3_HUMANBioGRID, HPRD, IntAct15231747 details
XRN2_HUMANTOLIP_HUMANBioGRID, HPRD, IntAct15231747 details
XRN2_HUMANTADBP_HUMANBioGRID, HPRD, IntAct15231747 20020773 32814053 details
XRN2_HUMANDISC1_HUMANBioGRID, IntAct, MINT17043677 29961565 31413325 details
XRN2_HUMANCSK21_HUMANBioGRID, IntAct22113938 details
XRN2_HUMANTTC23_HUMANBioGRID, IntAct32296183 details
XRN2_HUMANNGAL_HUMANBioGRID, IntAct32296183 details
XRN2_HUMANXRN2_HUMANBioGRID, IntAct32296183 details
XRN2_HUMANCRY2_HUMANBioGRID, IntAct25756610 32296183 details
XRN2_HUMANPKHF2_HUMANBioGRID, IntAct32296183 details
XRN2_HUMANEF1A1_HUMANBioGRID, HPRD15231747 details
XRN2_HUMANATRN_HUMANBioGRID15231747 details
XRN2_HUMANCATC_HUMANBioGRID15231747 details
XRN2_HUMANAL1B1_HUMANBioGRID15231747 details
XRN2_HUMANPRAME_HUMANBioGRID15231747 details
XRN2_HUMANRT10_HUMANBioGRID15231747 29395067 details
XRN2_HUMANRM04_HUMANBioGRID15231747 29395067 details
XRN2_HUMANERG_HUMANBioGRID24591637 details
XRN2_HUMANDYLT1_HUMANBioGRID30217970 details
XRN2_HUMANOGT1_HUMANBioGRID32994395 details
XRN2_HUMANE2AK2_HUMANBioGRID, IntAct21903422 29395067 details
XRN2_HUMANCARF_HUMANBioGRID, IntAct24778252 26496610 29395067 details
XRN2_HUMANC2AIL_HUMANBioGRID, DIP, IntAct24778252 26496610 26779609 29395067 details
XRN2_HUMANDCAF7_HUMANBioGRID, IntAct27173435 unassigned1312 details
XRN2_HUMANDDX21_HUMANDIP25470060 details
XRN2_HUMANA4_HUMANIntAct31413325 details
XRN2_HUMANAICDA_HUMANBioGRID23277564 details
XRN2_HUMANNKRF_HUMANBioGRID24778252 29395067 details
XRN2_HUMANMOV10_HUMANBioGRID22658674 29395067 details
XRN2_HUMANNXF1_HUMANBioGRID22658674 29395067 details
XRN2_HUMANILF3_HUMANBioGRID29395067 details
XRN2_HUMANSMG7_HUMANBioGRID29395067 details
XRN2_HUMANCCAR2_HUMANBioGRID29395067 details
XRN2_HUMANCLP1_HUMANBioGRID29395067 details
XRN2_HUMANCPSF6_HUMANBioGRID29395067 details
XRN2_HUMANRT29_HUMANBioGRID29395067 details
XRN2_HUMANDHX15_HUMANBioGRID29395067 details
XRN2_HUMANROA2_HUMANBioGRID29395067 details
XRN2_HUMANROA3_HUMANBioGRID29395067 details
XRN2_HUMANROAA_HUMANBioGRID29395067 details
XRN2_HUMANHNRPC_HUMANBioGRID29395067 details
XRN2_HUMANHNRPK_HUMANBioGRID29395067 details
XRN2_HUMANHNRPL_HUMANBioGRID29395067 details
XRN2_HUMANHNRPR_HUMANBioGRID29395067 details
XRN2_HUMANHNRL1_HUMANBioGRID29395067 details
XRN2_HUMANILF2_HUMANBioGRID29395067 details
XRN2_HUMANLAS1L_HUMANBioGRID29395067 details
XRN2_HUMANRT27_HUMANBioGRID29395067 details
XRN2_HUMANRT31_HUMANBioGRID29395067 details
XRN2_HUMANRT34_HUMANBioGRID29395067 details
XRN2_HUMANRT35_HUMANBioGRID29395067 details
XRN2_HUMANRT07_HUMANBioGRID29395067 details
XRN2_HUMANRT09_HUMANBioGRID29395067 details
XRN2_HUMANNOL11_HUMANBioGRID29395067 details
XRN2_HUMANNOL9_HUMANBioGRID29395067 details
XRN2_HUMANPCF11_HUMANBioGRID29395067 details
XRN2_HUMANPCID2_HUMANBioGRID29395067 details
XRN2_HUMANRRP5_HUMANBioGRID29395067 details
XRN2_HUMANPTBP3_HUMANBioGRID29395067 details
XRN2_HUMANPTCD3_HUMANBioGRID29395067 details
XRN2_HUMANRALY_HUMANBioGRID29395067 details
XRN2_HUMANRAVR1_HUMANBioGRID29395067 details
XRN2_HUMANRBM20_HUMANBioGRID29395067 details
XRN2_HUMANRBM6_HUMANBioGRID29395067 details
XRN2_HUMANRBMX_HUMANBioGRID29395067 details
XRN2_HUMANSRSF9_HUMANBioGRID29395067 details
XRN2_HUMANSTRBP_HUMANBioGRID29395067 details
XRN2_HUMANHNRPQ_HUMANBioGRID29395067 details
XRN2_HUMANTEX10_HUMANBioGRID29395067 details
XRN2_HUMANTRA2B_HUMANBioGRID29395067 details
XRN2_HUMANUBR5_HUMANBioGRID29395067 details
XRN2_HUMANUTP15_HUMANBioGRID29395067 details
XRN2_HUMANUTP4_HUMANBioGRID29395067 34079125 details
XRN2_HUMANWDR33_HUMANBioGRID29395067 details
XRN2_HUMANWDR43_HUMANBioGRID29395067 details
XRN2_HUMANWDR75_HUMANBioGRID29395067 details
XRN2_HUMANYLPM1_HUMANBioGRID29395067 details
XRN2_HUMANZC3H4_HUMANBioGRID29395067 details
XRN2_HUMANZFR_HUMANBioGRID29395067 details
XRN2_HUMANAQR_HUMANBioGRID29395067 details
XRN2_HUMANCEBPZ_HUMANBioGRID29395067 details
XRN2_HUMANRT22_HUMANBioGRID29395067 details
XRN2_HUMANRT23_HUMANBioGRID29395067 details
XRN2_HUMANRT24_HUMANBioGRID29395067 details
XRN2_HUMANRT26_HUMANBioGRID29395067 details
XRN2_HUMANPPHLN_HUMANBioGRID29395067 details
XRN2_HUMANRBM33_HUMANBioGRID29395067 details
XRN2_HUMANSRSF1_HUMANBioGRID29395067 details
XRN2_HUMANTBL3_HUMANBioGRID29395067 details
XRN2_HUMANUTP18_HUMANBioGRID29395067 details
XRN2_HUMANRRS1_HUMANBioGRID29395067 details
XRN2_HUMANRM01_HUMANBioGRID29395067 details
XRN2_HUMANRM15_HUMANBioGRID29395067 details
XRN2_HUMANRM22_HUMANBioGRID29395067 details
XRN2_HUMANRM38_HUMANBioGRID29395067 details
XRN2_HUMANRM39_HUMANBioGRID29395067 details
XRN2_HUMANRM47_HUMANBioGRID29395067 details
XRN2_HUMANRM50_HUMANBioGRID29395067 details
XRN2_HUMANRT14_HUMANBioGRID29395067 details
XRN2_HUMANRT18B_HUMANBioGRID29395067 details
XRN2_HUMANNOC4L_HUMANBioGRID29395067 details
XRN2_HUMANPSPC1_HUMANBioGRID29395067 details
XRN2_HUMANRBM12_HUMANBioGRID29395067 details
XRN2_HUMANWDR3_HUMANBioGRID29395067 details
XRN2_HUMANZN106_HUMANBioGRID29395067 details