Entity Details

Primary name SOX17_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9H6I2
EntryNameSOX17_HUMAN
FullNameTranscription factor SOX-17
TaxID9606
Evidenceevidence at protein level
Length414
SequenceStatuscomplete
DateCreated2002-10-10
DateModified2021-06-02

Ontological Relatives

GenesSOX17

GO terms

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GOName
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001525 angiogenesis
GO:0001570 vasculogenesis
GO:0001656 metanephros development
GO:0001706 endoderm formation
GO:0001714 endodermal cell fate specification
GO:0001828 inner cell mass cellular morphogenesis
GO:0001947 heart looping
GO:0003142 cardiogenic plate morphogenesis
GO:0003143 embryonic heart tube morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0003308 negative regulation of Wnt signaling pathway involved in heart development
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007283 spermatogenesis
GO:0007493 endodermal cell fate determination
GO:0007507 heart development
GO:0008013 beta-catenin binding
GO:0008134 transcription factor binding
GO:0009653 anatomical structure morphogenesis
GO:0010628 positive regulation of gene expression
GO:0016055 Wnt signaling pathway
GO:0021903 rostrocaudal neural tube patterning
GO:0023019 signal transduction involved in regulation of gene expression
GO:0030154 cell differentiation
GO:0030308 negative regulation of cell growth
GO:0031648 protein destabilization
GO:0035050 embryonic heart tube development
GO:0042074 cell migration involved in gastrulation
GO:0045597 positive regulation of cell differentiation
GO:0045732 positive regulation of protein catabolic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0045995 regulation of embryonic development
GO:0048617 embryonic foregut morphogenesis
GO:0048866 stem cell fate specification
GO:0050821 protein stabilization
GO:0060214 endocardium formation
GO:0060913 cardiac cell fate determination
GO:0060914 heart formation
GO:0060956 endocardial cell differentiation
GO:0061009 common bile duct development
GO:0061010 gall bladder development
GO:0061031 endodermal digestive tract morphogenesis
GO:0072091 regulation of stem cell proliferation
GO:0072189 ureter development
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:1990830 cellular response to leukemia inhibitory factor
GO:2000035 regulation of stem cell division
GO:2000043 regulation of cardiac cell fate specification

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR009071 High mobility group box domainDomainDomain
IPR021934 Sox, C-terminalDomainDomain
IPR033392 Sox 7/17/18, central domainDomainDomain
IPR036910 High mobility group box domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
613674 OMIMVesicoureteral reflux 3 (VUR3)A disease belonging to the group of congenital anomalies of the kidney and urinary tract. It is characterized by the reflux of urine from the bladder into the ureters and sometimes into the kidneys, and is a risk factor for urinary tract infections. Primary disease results from a developmental defect of the ureterovesical junction. In combination with intrarenal reflux, the resulting inflammatory reaction may result in renal injury or scarring, also called reflux nephropathy. Extensive renal scarring impairs renal function and may predispose patients to hypertension, proteinuria, renal insufficiency and end-stage renal disease. The disease is caused by variants affecting the gene represented in this entry.

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
SOX17_HUMANAPBA3_HUMANUniProt26948053 details
SOX17_HUMANCTNB1_HUMANbhf-ucl, HPRD15163629 17875931 details