Entity Details

Primary name GBA2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9HCG7
EntryNameGBA2_HUMAN
FullNameNon-lysosomal glucosylceramidase
TaxID9606
Evidenceevidence at protein level
Length927
SequenceStatuscomplete
DateCreated2007-04-03
DateModified2021-06-02

Ontological Relatives

GenesGBA2

GO terms

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GOName
GO:0004348 glucosylceramidase activity
GO:0005790 smooth endoplasmic reticulum
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005975 carbohydrate metabolic process
GO:0006680 glucosylceramide catabolic process
GO:0006687 glycosphingolipid metabolic process
GO:0007417 central nervous system development
GO:0008203 cholesterol metabolic process
GO:0008206 bile acid metabolic process
GO:0008422 beta-glucosidase activity
GO:0016021 integral component of membrane
GO:0016139 glycoside catabolic process
GO:0019898 extrinsic component of membrane
GO:0021954 central nervous system neuron development
GO:0030259 lipid glycosylation
GO:0030833 regulation of actin filament polymerization
GO:0031113 regulation of microtubule polymerization
GO:0042406 extrinsic component of endoplasmic reticulum membrane
GO:0046527 glucosyltransferase activity
GO:0050295 steryl-beta-glucosidase activity
GO:0090498 extrinsic component of Golgi membrane
GO:0097035 regulation of membrane lipid distribution

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane
Golgi apparatus membrane

Domains

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DomainNameCategoryType
IPR006775 Glycosyl-hydrolase family 116, catalytic regionDomainDomain
IPR008928 Six-hairpin glycosidase superfamilyFamilyHomologous superfamily
IPR012341 Six-hairpin glycosidase-like superfamilyFamilyHomologous superfamily
IPR014551 Beta-glucosidase GBA2-typeFamilyFamily
IPR024462 Glycosyl-hydrolase family 116, N-terminalDomainDomain

Diseases

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Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
GBA2_HUMANMTR1A_HUMANBioGRID, IntAct26514267 details
GBA2_HUMANPCNA_HUMANUniProt26030842 details
GBA2_HUMANA4_HUMANBioGRID21832049 details