Entity Details

Primary name HEYL_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NQ87
EntryNameHEYL_HUMAN
FullNameHairy/enhancer-of-split related with YRPW motif-like protein
TaxID9606
Evidenceevidence at protein level
Length328
SequenceStatuscomplete
DateCreated2007-05-01
DateModified2021-06-02

Ontological Relatives

GenesHEYL

GO terms

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GOName
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003151 outflow tract morphogenesis
GO:0003180 aortic valve morphogenesis
GO:0003181 atrioventricular valve morphogenesis
GO:0003184 pulmonary valve morphogenesis
GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0003203 endocardial cushion morphogenesis
GO:0003208 cardiac ventricle morphogenesis
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007219 Notch signaling pathway
GO:0007221 positive regulation of transcription of Notch receptor target
GO:0008134 transcription factor binding
GO:0009952 anterior/posterior pattern specification
GO:0010629 negative regulation of gene expression
GO:0014031 mesenchymal cell development
GO:0032835 glomerulus development
GO:0035914 skeletal muscle cell differentiation
GO:0042803 protein homodimerization activity
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0045666 positive regulation of neuron differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0050683 AF-1 domain binding
GO:0050767 regulation of neurogenesis
GO:0060317 cardiac epithelial to mesenchymal transition
GO:0060412 ventricular septum morphogenesis
GO:0060766 negative regulation of androgen receptor signaling pathway
GO:0061314 Notch signaling involved in heart development
GO:0071773 cellular response to BMP stimulus
GO:0072014 proximal tubule development

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR003650 Orange domainDomainDomain
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domainDomainDomain
IPR036638 Helix-loop-helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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