Entity Details

Primary name EXOS3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NQT5
EntryNameEXOS3_HUMAN
FullNameExosome complex component RRP40
TaxID9606
Evidenceevidence at protein level
Length275
SequenceStatuscomplete
DateCreated2001-06-01
DateModified2021-06-02

Ontological Relatives

GenesEXOSC3

GO terms

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GOName
GO:0000175 3'-5'-exoribonuclease activity
GO:0000176 nuclear exosome (RNase complex)
GO:0000177 cytoplasmic exosome (RNase complex)
GO:0000178 exosome (RNase complex)
GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0003723 RNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006364 rRNA processing
GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
GO:0034475 U4 snRNA 3'-end processing
GO:0035327 transcriptionally active chromatin
GO:0043488 regulation of mRNA stability
GO:0043928 exonucleolytic catabolism of deadenylated mRNA
GO:0045006 DNA deamination
GO:0045190 isotype switching
GO:0045830 positive regulation of isotype switching
GO:0071034 CUT catabolic process
GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process
GO:0071038 nuclear polyadenylation-dependent tRNA catabolic process
GO:0071049 nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription
GO:0071051 polyadenylation-dependent snoRNA 3'-end processing

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR004088 K Homology domain, type 1DomainDomain
IPR012340 Nucleic acid-binding, OB-foldFamilyHomologous superfamily
IPR026699 Exosome complex RNA-binding protein 1/RRP40/RRP4FamilyFamily
IPR036612 K Homology domain, type 1 superfamilyFamilyHomologous superfamily
IPR037319 Rrp40, S1 domainDomainDomain

Diseases

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Interactions

18 interactions

InteractorPartnerSourcesPublicationsLink
EXOS3_HUMANEXOS4_HUMANBioGRID, HPRD, IntAct, MINT15231747 20531386 20531389 21255825 22939629 24981860 26186194 26344197 26496610 28514442 32188736 details
EXOS3_HUMANEXOS5_HUMANBioGRID, HPRD, IntAct, MINT11110791 12419256 15231747 20531389 21255825 22939629 24981860 26186194 26344197 26496610 28514442 32188736 details
EXOS3_HUMANEXOS8_HUMANBioGRID, IntAct, MINT15231747 20531389 21255825 24981860 26186194 28514442 details
EXOS3_HUMANCK5P1_HUMANBioGRID, HPRD, IntAct15231747 details
EXOS3_HUMANEXOS9_HUMANBioGRID, HPRD, IntAct, MINT12788944 20531389 22939629 24981860 26186194 26344197 26496610 28514442 details
EXOS3_HUMANMPH6_HUMANBioGRID, IntAct, MINT20531389 24981860 26186194 26344197 28514442 28877463 details
EXOS3_HUMANTSR2_HUMANBioGRID, IntAct32296183 details
EXOS3_HUMANHBS1L_HUMANBioGRID, IntAct, MINT24981860 26186194 27345150 28514442 details
EXOS3_HUMANA4_HUMANBioGRID21832049 details
EXOS3_HUMANATPD_HUMANBioGRID15231747 details
EXOS3_HUMANOSTM1_HUMANBioGRID32188736 details
EXOS3_HUMANDI3L1_HUMANBioGRID, IntAct, MINT20531386 20531389 23756462 24981860 26186194 26496610 28514442 details
EXOS3_HUMANEXOS2_HUMANBioGRID, IntAct, MINT, UniProt11719186 16396833 17545563 20531389 21255825 22939629 24981860 26186194 26344197 26496610 28514442 32188736 details
EXOS3_HUMANRRP44_HUMANBioGRID, IntAct, MINT20531386 20531389 21255825 details
EXOS3_HUMANEXOS3_HUMANBioGRID, IntAct20531389 21255825 details
EXOS3_HUMANDDX17_HUMANDIP18334637 details
EXOS3_HUMANZCCHV_HUMANDIP21876179 details
EXOS3_HUMANFUBP2_HUMANHPRD15175153 details