Entity Details

Primary name TLR9_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NR96
EntryNameTLR9_HUMAN
FullNameToll-like receptor 9
TaxID9606
Evidenceevidence at protein level
Length1032
SequenceStatuscomplete
DateCreated2002-01-31
DateModified2021-06-02

Ontological Relatives

GenesTLR9

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0002224 toll-like receptor signaling pathway
GO:0002237 response to molecule of bacterial origin
GO:0002639 positive regulation of immunoglobulin production
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0004888 transmembrane signaling receptor activity
GO:0005149 interleukin-1 receptor binding
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005768 endosome
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007252 I-kappaB phosphorylation
GO:0010008 endosome membrane
GO:0010628 positive regulation of gene expression
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0030277 maintenance of gastrointestinal epithelium
GO:0030890 positive regulation of B cell proliferation
GO:0032009 early phagosome
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032640 tumor necrosis factor production
GO:0032715 negative regulation of interleukin-6 production
GO:0032717 negative regulation of interleukin-8 production
GO:0032722 positive regulation of chemokine production
GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032727 positive regulation of interferon-alpha production
GO:0032728 positive regulation of interferon-beta production
GO:0032729 positive regulation of interferon-gamma production
GO:0032733 positive regulation of interleukin-10 production
GO:0032735 positive regulation of interleukin-12 production
GO:0032741 positive regulation of interleukin-18 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0034122 negative regulation of toll-like receptor signaling pathway
GO:0034123 positive regulation of toll-like receptor signaling pathway
GO:0034162 toll-like receptor 9 signaling pathway
GO:0034163 regulation of toll-like receptor 9 signaling pathway
GO:0035197 siRNA binding
GO:0036019 endolysosome
GO:0036020 endolysosome membrane
GO:0038187 pattern recognition receptor activity
GO:0042742 defense response to bacterium
GO:0042803 protein homodimerization activity
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043410 positive regulation of MAPK cascade
GO:0043507 positive regulation of JUN kinase activity
GO:0045087 innate immune response
GO:0045322 unmethylated CpG binding
GO:0045577 regulation of B cell differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046330 positive regulation of JNK cascade
GO:0050729 positive regulation of inflammatory response
GO:0050829 defense response to Gram-negative bacterium
GO:0050871 positive regulation of B cell activation
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051607 defense response to virus
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1901895 negative regulation of ATPase-coupled calcium transmembrane transporter activity

Subcellular Location

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Subcellular Location
Cytoplasmic vesicle
Endoplasmic reticulum membrane
Endosome
Lysosome

Domains

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DomainNameCategoryType
IPR000157 Toll/interleukin-1 receptor homology (TIR) domainDomainDomain
IPR001611 Leucine-rich repeatRepeatRepeat
IPR003591 Leucine-rich repeat, typical subtypeRepeatRepeat
IPR027181 Toll-like receptor 9FamilyFamily
IPR035897 Toll/interleukin-1 receptor homology (TIR) domain superfamilyFamilyHomologous superfamily
IPR041283 Leucine-rich repeat unitRepeatRepeat

Diseases

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Drugs

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DrugNameSourceType
DB00608 ChloroquineDrugbanksmall molecule
DB01611 HydroxychloroquineDrugbanksmall molecule
DB05463 ISS-1018Drugbanksmall molecule
DB05475 GolotimodDrugbanksmall molecule
DB05530 CPG 10101Drugbankbiotech