Entity Details

Primary name ADPRS_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NX46
EntryNameADPRS_HUMAN
FullNameADP-ribose glycohydrolase ARH3
TaxID9606
Evidenceevidence at protein level
Length363
SequenceStatuscomplete
DateCreated2007-02-06
DateModified2021-06-02

Ontological Relatives

GenesADPRS

GO terms

Show/Hide Table
GOName
GO:0000287 magnesium ion binding
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004649 poly(ADP-ribose) glycohydrolase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0006281 DNA repair
GO:0006287 base-excision repair, gap-filling
GO:0016604 nuclear body
GO:0061463 O-acetyl-ADP-ribose deacetylase activity
GO:0071451 cellular response to superoxide
GO:0090734 site of DNA damage
GO:0140290 peptidyl-serine ADP-deribosylation
GO:0140292 ADP-ribosylserine hydrolase activity

Subcellular Location

Show/Hide Table
Subcellular Location
Chromosome
Cytoplasm
Mitochondrion matrix
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR005502 ADP-ribosylation/Crystallin J1FamilyFamily
IPR036705 ADP-ribosylation/Crystallin J1 superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
618170 OMIMNeurodegeneration, childhood-onset, stress-induced, with variable ataxia and seizures (CONDSIAS)An autosomal recessive neurodegenerative disorder characterized by pediatric onset of progressive brain atrophy, developmental regression, and seizures in association with periods of stress, such as infections. The disease is caused by variants affecting the gene represented in this entry.

Interactions

5 interactions

InteractorPartnerSourcesPublicationsLink
ADPRS_HUMANF10C1_HUMANBioGRID, IntAct16169070 details
ADPRS_HUMANHEXD_HUMANBioGRID, HPRD, IntAct16169070 details
ADPRS_HUMANHSPB1_HUMANBioGRID, IntAct25277244 details
ADPRS_HUMANTNKS1_HUMANBioGRID, IntAct32296183 details
ADPRS_HUMANPRDM5_HUMANBioGRID, IntAct32296183 details