Entity Details

Primary name PDP1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9P0J1
EntryNamePDP1_HUMAN
FullName[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length537
SequenceStatuscomplete
DateCreated2001-01-24
DateModified2021-06-02

Ontological Relatives

GenesPDP1

GO terms

Show/Hide Table
GOName
GO:0004722 protein serine/threonine phosphatase activity
GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0006470 protein dephosphorylation
GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate
GO:0035970 peptidyl-threonine dephosphorylation
GO:0046872 metal ion binding
GO:1904184 positive regulation of pyruvate dehydrogenase activity

Subcellular Location

Show/Hide Table
Subcellular Location
Mitochondrion matrix

Domains

Show/Hide Table
DomainNameCategoryType
IPR000222 PPM-type phosphatase, divalent cation bindingSiteBinding site
IPR001932 PPM-type phosphatase domainDomainDomain
IPR015655 Protein phosphatase 2C familyFamilyFamily
IPR036457 PPM-type phosphatase domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
608782 OMIMPyruvate dehydrogenase phosphatase deficiency (PDP deficiency)Results in lactic acidosis leading to neurological dysfunction. The disease is caused by variants affecting the gene represented in this entry.