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Entity Details
Primary name
HECW2_HUMAN
Entity type
UniProt
Source
Source Link
Details
Accession
Q9P2P5
EntryName
HECW2_HUMAN
FullName
E3 ubiquitin-protein ligase HECW2
TaxID
9606
Evidence
evidence at protein level
Length
1572
SequenceStatus
complete
DateCreated
2007-02-20
DateModified
2021-06-02
Ontological Relatives
Genes
HECW2
GO terms
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GO
Name
GO:0000209
protein polyubiquitination
GO:0005737
cytoplasm
GO:0016567
protein ubiquitination
GO:0030071
regulation of mitotic metaphase/anaphase transition
GO:0043161
proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045732
positive regulation of protein catabolic process
GO:0048814
regulation of dendrite morphogenesis
GO:0061630
ubiquitin protein ligase activity
GO:0072686
mitotic spindle
GO:2000650
negative regulation of sodium ion transmembrane transporter activity
Subcellular Location
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Subcellular Location
Cytoplasm
Domains
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Domain
Name
Category
Type
IPR000008
C2 domain
Domain
Domain
IPR000569
HECT domain
Domain
Domain
IPR001202
WW domain
Domain
Domain
IPR032348
E3 ubiquitin-protein ligase HECW1/2, N-terminal
Domain
Domain
IPR035892
C2 domain superfamily
Family
Homologous superfamily
IPR035983
HECT, E3 ligase catalytic domain
Family
Homologous superfamily
IPR036020
WW domain superfamily
Family
Homologous superfamily
IPR037795
E3 ubiquitin-protein ligase HECW, C2 domain
Domain
Domain
IPR040524
E3 ubiquitin-protein ligase HECW1, helical box domain
Domain
Domain
Diseases
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Drugs
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Interactions
17 interactions
Interactor
Partner
Sources
Publications
Link
HECW2_HUMAN
P73_HUMAN
BioGRID, HPRD
12890487
details
HECW2_HUMAN
FZR1_HUMAN
BioGRID
24163370
details
HECW2_HUMAN
CBX3_HUMAN
BioGRID
24163370
30208514
details
HECW2_HUMAN
UB2D3_HUMAN
BioGRID
12890487
details
HECW2_HUMAN
UB2L3_HUMAN
BioGRID
12890487
26949039
details
HECW2_HUMAN
HECW2_HUMAN
BioGRID
26949039
details
HECW2_HUMAN
UB2D2_HUMAN
BioGRID
29643511
details
HECW2_HUMAN
CBX1_HUMAN
BioGRID
30208514
details
HECW2_HUMAN
CBX5_HUMAN
BioGRID
30208514
details
HECW2_HUMAN
FXL15_HUMAN
BioGRID, MINT
21572392
details
HECW2_HUMAN
P53_HUMAN
BioGRID
12890487
details
HECW2_HUMAN
AMOL1_HUMAN
BioGRID
24163370
27498087
details
HECW2_HUMAN
LMNB1_HUMAN
BioGRID
24163370
29753763
details
HECW2_HUMAN
AMOT_HUMAN
BioGRID
27498087
details
HECW2_HUMAN
AMOL2_HUMAN
BioGRID
27498087
details
HECW2_HUMAN
PCNA_HUMAN
BioGRID
29753763
details
HECW2_HUMAN
LMNA_HUMAN
BioGRID
29753763
details
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