Entity Details

Primary name AASS_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UDR5
EntryNameAASS_HUMAN
FullNameAlpha-aminoadipic semialdehyde synthase, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length926
SequenceStatuscomplete
DateCreated2004-04-13
DateModified2021-06-02

Ontological Relatives

GenesAASS

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0003714 transcription corepressor activity
GO:0004753 saccharopine dehydrogenase activity
GO:0004754 saccharopine dehydrogenase (NAD+, L-lysine-forming) activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0006554 lysine catabolic process
GO:0019878 lysine biosynthetic process via aminoadipic acid
GO:0031061 negative regulation of histone methylation
GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine
GO:0042393 histone binding
GO:0043231 intracellular membrane-bounded organelle
GO:0047130 saccharopine dehydrogenase (NADP+, L-lysine-forming) activity
GO:0047131 saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity

Subcellular Location

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Subcellular Location
Mitochondrion

Domains

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DomainNameCategoryType
IPR005097 Saccharopine dehydrogenase, NADP binding domainDomainDomain
IPR007698 Alanine dehydrogenase/pyridine nucleotide transhydrogenase, NAD(H)-binding domainDomainDomain
IPR007886 Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminalDomainDomain
IPR032095 Saccharopine dehydrogenase-like, C-terminalDomainDomain
IPR036291 NAD(P)-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00142 Glutamic acidDrugbanksmall molecule
DB00157 NADHDrugbanksmall molecule
DB02338 NADPHDrugbanksmall molecule
DB04207 L-SaccharopineDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
AASS_HUMANOGT1_HUMANBioGRID32994395 details
AASS_HUMANTERF2_HUMANBioGRID20811636 details