Entity Details

Primary name KLOT_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UEF7
EntryNameKLOT_HUMAN
FullNameKlotho
TaxID9606
Evidenceevidence at protein level
Length1012
SequenceStatuscomplete
DateCreated2005-10-11
DateModified2021-06-02

Ontological Relatives

GenesKL

GO terms

Show/Hide Table
GOName
GO:0000165 MAPK cascade
GO:0004566 beta-glucuronidase activity
GO:0005104 fibroblast growth factor receptor binding
GO:0005179 hormone activity
GO:0005499 vitamin D binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005975 carbohydrate metabolic process
GO:0006112 energy reserve metabolic process
GO:0007568 aging
GO:0008286 insulin receptor signaling pathway
GO:0008422 beta-glucosidase activity
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0017134 fibroblast growth factor binding
GO:0030501 positive regulation of bone mineralization
GO:0051897 positive regulation of protein kinase B signaling
GO:0055074 calcium ion homeostasis
GO:0070062 extracellular exosome
GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

Subcellular Location

Show/Hide Table
Subcellular Location
Apical cell membrane
Cell membrane
Secreted

Domains

Show/Hide Table
DomainNameCategoryType
IPR001360 Glycoside hydrolase family 1FamilyFamily
IPR017853 Glycoside hydrolase superfamilyFamilyHomologous superfamily
IPR028546 KlothoFamilyFamily
IPR033132 Glycosyl hydrolases family 1, N-terminal conserved siteSiteConserved site

Diseases

Show/Hide Table

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
KLOT_HUMANFGF23_HUMANBioGRID27879395 details
KLOT_HUMANIGF1R_HUMANHPRD18762812 details