Entity Details

Primary name VAV3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UKW4
EntryNameVAV3_HUMAN
FullNameGuanine nucleotide exchange factor VAV3
TaxID9606
Evidenceevidence at protein level
Length847
SequenceStatuscomplete
DateCreated2001-01-24
DateModified2021-06-02

Ontological Relatives

GenesVAV3

GO terms

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GOName
GO:0001525 angiogenesis
GO:0001772 immunological synapse
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005096 GTPase activator activity
GO:0005154 epidermal growth factor receptor binding
GO:0005829 cytosol
GO:0006906 vesicle fusion
GO:0006974 cellular response to DNA damage stimulus
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007229 integrin-mediated signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0008361 regulation of cell size
GO:0030032 lamellipodium assembly
GO:0030168 platelet activation
GO:0030593 neutrophil chemotaxis
GO:0030890 positive regulation of B cell proliferation
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042493 response to drug
GO:0043065 positive regulation of apoptotic process
GO:0043087 regulation of GTPase activity
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0045785 positive regulation of cell adhesion
GO:0046872 metal ion binding
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048013 ephrin receptor signaling pathway
GO:0050853 B cell receptor signaling pathway
GO:0051056 regulation of small GTPase mediated signal transduction

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000219 Dbl homology (DH) domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved siteSiteConserved site
IPR001452 SH3 domainDomainDomain
IPR001715 Calponin homology domainDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domainDomainDomain
IPR003096 Smooth muscle protein/calponinFamilyFamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR022613 Calmodulin-regulated spectrin-associated protein, CH domainDomainDomain
IPR035734 VAV3 protein, second SH3 domainDomainDomain
IPR035881 VAV3, SH2 domainDomainDomain
IPR035899 Dbl homology (DH) domain superfamilyFamilyHomologous superfamily
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily
IPR036872 CH domain superfamilyFamilyHomologous superfamily
IPR037832 Vav, PH domainDomainDomain

Diseases

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Interactions

33 interactions

InteractorPartnerSourcesPublicationsLink
VAV3_HUMANGRB2_HUMANBioGRID, HPRD, IntAct11094073 12577067 18654987 20936779 21706016 32296183 details
VAV3_HUMANERBB2_HUMANBioGRID, MINT16273093 22973453 details
VAV3_HUMANERBB3_HUMANBioGRID, MINT16273093 22973453 details
VAV3_HUMANESR1_HUMANBioGRID, IntAct18518979 details
VAV3_HUMANANDR_HUMANBioGRID, IntAct24728074 details
VAV3_HUMANGAB1_HUMANBioGRID, IntAct24728074 details
VAV3_HUMANKIT_HUMANBioGRID, IntAct24728074 details
VAV3_HUMANMET_HUMANBioGRID, IntAct24728074 details
VAV3_HUMANRINT1_HUMANBioGRID, IntAct32296183 details
VAV3_HUMANCBLB_HUMANBioGRID, IntAct32296183 details
VAV3_HUMANZRAN1_HUMANBioGRID, IntAct32296183 details
VAV3_HUMANEGFR_HUMANBioGRID, HPRD, IntAct10938113 11094073 22973453 24797263 25754235 31585087 details
VAV3_HUMANRAC1_HUMANBioGRID, HPRD10523675 details
VAV3_HUMANRHOA_HUMANBioGRID, HPRD10523675 32203420 details
VAV3_HUMANRHOG_HUMANBioGRID, HPRD10523675 details
VAV3_HUMANROS1_HUMANBioGRID, HPRD11094073 details
VAV3_HUMANERBB4_HUMANBioGRID22973453 details
VAV3_HUMANZYX_HUMANHPRD8622875 details
VAV3_HUMANP85A_HUMANHPRD, MINT11094073 16982329 details
VAV3_HUMAN3BP2_HUMANHPRD, MINT14757747 15345594 details
VAV3_HUMANT2FB_HUMANIntAct20195357 details
VAV3_HUMANALK_HUMANMINT17998938 details
VAV3_HUMANPGFRB_HUMANBioGRID10938113 details
VAV3_HUMANINSR_HUMANBioGRID, HPRD11094073 details
VAV3_HUMANIGF1R_HUMANBioGRID, HPRD11094073 details
VAV3_HUMANSHC1_HUMANBioGRID, HPRD11094073 details
VAV3_HUMANBLNK_HUMANBioGRID21822214 details
VAV3_HUMANTRAF6_HUMANBioGRID27507811 details
VAV3_HUMANTNR11_HUMANBioGRID27507811 details
VAV3_HUMANTRAF1_HUMANBioGRID27507811 details
VAV3_HUMANTRAF3_HUMANBioGRID27507811 details
VAV3_HUMANPLCG1_HUMANHPRD11094073 details
VAV3_HUMANLCP2_HUMANHPRD14757747 15708849 details