Entity Details

Primary name BOK_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UMX3
EntryNameBOK_HUMAN
FullNameBcl-2-related ovarian killer protein
TaxID9606
Evidenceevidence at protein level
Length212
SequenceStatuscomplete
DateCreated2005-01-04
DateModified2021-06-02

Ontological Relatives

GenesBOK

GO terms

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GOName
GO:0001836 release of cytochrome c from mitochondria
GO:0005102 signaling receptor binding
GO:0005634 nucleus
GO:0005640 nuclear outer membrane
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005743 mitochondrial inner membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006921 cellular component disassembly involved in execution phase of apoptosis
GO:0007420 brain development
GO:0008584 male gonad development
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0010506 regulation of autophagy
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031625 ubiquitin protein ligase binding
GO:0031901 early endosome membrane
GO:0031966 mitochondrial membrane
GO:0032588 trans-Golgi network membrane
GO:0033106 cis-Golgi network membrane
GO:0042803 protein homodimerization activity
GO:0043065 positive regulation of apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0044877 protein-containing complex binding
GO:0046982 protein heterodimerization activity
GO:0048709 oligodendrocyte differentiation
GO:0051259 protein complex oligomerization
GO:0051400 BH domain binding
GO:0051402 neuron apoptotic process
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0051902 negative regulation of mitochondrial depolarization
GO:0055038 recycling endosome membrane
GO:0060546 negative regulation of necroptotic process
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:1900119 positive regulation of execution phase of apoptosis
GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1901382 regulation of chorionic trophoblast cell proliferation
GO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1903899 positive regulation of PERK-mediated unfolded protein response
GO:1904708 regulation of granulosa cell apoptotic process
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm
Early endosome membrane
Endoplasmic reticulum
Endoplasmic reticulum membrane
Golgi apparatus
Membrane
Mitochondrion
Mitochondrion inner membrane
Mitochondrion membrane
Mitochondrion outer membrane
Nucleus
Nucleus outer membrane
Recycling endosome membrane

Domains

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DomainNameCategoryType
IPR002475 Bcl2-likeFamilyFamily
IPR026298 Bcl-2 familyFamilyFamily
IPR026309 Bcl-2-related ovarian killer proteinFamilyFamily
IPR036834 Bcl-2-like superfamilyFamilyHomologous superfamily

Diseases

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