Entity Details

Primary name RIPK3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y572
EntryNameRIPK3_HUMAN
FullNameReceptor-interacting serine/threonine-protein kinase 3
TaxID9606
Evidenceevidence at protein level
Length518
SequenceStatuscomplete
DateCreated2002-05-02
DateModified2021-06-02

Ontological Relatives

GenesRIPK3

GO terms

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GOName
GO:0001914 regulation of T cell mediated cytotoxicity
GO:0002819 regulation of adaptive immune response
GO:0003713 transcription coactivator activity
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004704 NF-kappaB-inducing kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006464 cellular protein modification process
GO:0007165 signal transduction
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0010922 positive regulation of phosphatase activity
GO:0019054 modulation by virus of host cellular process
GO:0032147 activation of protein kinase activity
GO:0032649 regulation of interferon-gamma production
GO:0032991 protein-containing complex
GO:0033077 T cell differentiation in thymus
GO:0042802 identical protein binding
GO:0042981 regulation of apoptotic process
GO:0043029 T cell homeostasis
GO:0044877 protein-containing complex binding
GO:0046006 regulation of activated T cell proliferation
GO:0046777 protein autophosphorylation
GO:0048535 lymph node development
GO:0048536 spleen development
GO:0048538 thymus development
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051351 positive regulation of ligase activity
GO:0051353 positive regulation of oxidoreductase activity
GO:0051607 defense response to virus
GO:0060544 regulation of necroptotic process
GO:0060545 positive regulation of necroptotic process
GO:0062099 negative regulation of programmed necrotic cell death
GO:0070235 regulation of activation-induced cell death of T cells
GO:0070266 necroptotic process
GO:0070301 cellular response to hydrogen peroxide
GO:0097190 apoptotic signaling pathway
GO:0097300 programmed necrotic cell death
GO:0097527 necroptotic signaling pathway
GO:0097528 execution phase of necroptosis
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1990000 amyloid fibril formation
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2000452 regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR025735 RHIM domainDomainDomain

Diseases

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Interactions

110 interactions

InteractorPartnerSourcesPublicationsLink
RIPK3_HUMANRIPK3_HUMANBioGRID, IntAct14743216 22817896 27045108 details
RIPK3_HUMANRIPK1_HUMANBioGRID, HPIDb, HPRD, IntAct10339433 19524512 19524513 21903422 22265413 22265414 22817896 22864571 23744296 24098568 25882049 26319693 26559832 26786097 29352166 29497034 29883609 30420664 31358971 details
RIPK3_HUMANRFX6_HUMANBioGRID, IntAct21988832 details
RIPK3_HUMANBIRC3_HUMANBioGRID, IntAct21931591 details
RIPK3_HUMANXIAP_HUMANBioGRID, IntAct21931591 details
RIPK3_HUMANBIRC2_HUMANBioGRID, IntAct21931591 details
RIPK3_HUMANMLKL_HUMANBioGRID, DIP, IntAct22265413 22265414 24316671 27560715 29883609 30420664 31358971 details
RIPK3_HUMANTRAF2_HUMANBioGRID, HPRD10339433 details
RIPK3_HUMANDAXX_HUMANBioGRID23260419 details
RIPK3_HUMANSRPK2_HUMANBioGRID26167880 details
RIPK3_HUMANPELI1_HUMANBioGRID29883609 details
RIPK3_HUMANH15_HUMANBioGRID29883609 details
RIPK3_HUMANBUB1B_HUMANBioGRID29883609 details
RIPK3_HUMANUTP11_HUMANBioGRID29883609 details
RIPK3_HUMANTMM44_HUMANBioGRID29883609 details
RIPK3_HUMANHELQ_HUMANBioGRID29883609 details
RIPK3_HUMANTLE6_HUMANBioGRID29883609 details
RIPK3_HUMANHBAP1_HUMANBioGRID29883609 details
RIPK3_HUMANGLGB_HUMANBioGRID29883609 details
RIPK3_HUMANIL24_HUMANBioGRID29883609 details
RIPK3_HUMANZSC20_HUMANBioGRID29883609 details
RIPK3_HUMANTXND3_HUMANBioGRID29883609 details
RIPK3_HUMANAIFM1_HUMANIntAct14743216 details
RIPK3_HUMAN1433E_HUMANIntAct14743216 details
RIPK3_HUMANPRDX1_HUMANIntAct14743216 details
RIPK3_HUMANADSV_HUMANIntAct14743216 details
RIPK3_HUMANHS71L_HUMANIntAct14743216 details
RIPK3_HUMANGBB2_HUMANIntAct14743216 details
RIPK3_HUMANBIP_HUMANIntAct14743216 details
RIPK3_HUMANDREB_HUMANIntAct14743216 details
RIPK3_HUMANHSP7C_HUMANIntAct14743216 details
RIPK3_HUMANCAZA1_HUMANIntAct14743216 details
RIPK3_HUMANADT2_HUMANIntAct14743216 details
RIPK3_HUMANGRP75_HUMANIntAct14743216 details
RIPK3_HUMANCOR1C_HUMANIntAct14743216 details
RIPK3_HUMANRUVB2_HUMANIntAct14743216 details
RIPK3_HUMANIQGA1_HUMANIntAct14743216 details
RIPK3_HUMANRL23_HUMANIntAct14743216 details
RIPK3_HUMANMYO1C_HUMANIntAct14743216 details
RIPK3_HUMANTCPE_HUMANIntAct14743216 details
RIPK3_HUMANGBB4_HUMANIntAct14743216 details
RIPK3_HUMANCDC37_HUMANBioGRID, IntAct14743216 21903422 details
RIPK3_HUMANDNJA1_HUMANIntAct14743216 details
RIPK3_HUMANSYEP_HUMANIntAct14743216 details
RIPK3_HUMANHNRH1_HUMANIntAct14743216 details
RIPK3_HUMANACTN4_HUMANIntAct14743216 details
RIPK3_HUMANMYO1B_HUMANIntAct14743216 details
RIPK3_HUMANC1QBP_HUMANIntAct14743216 details
RIPK3_HUMANEF1A2_HUMANIntAct14743216 details
RIPK3_HUMANSPTN1_HUMANIntAct14743216 details
RIPK3_HUMANTIAF1_HUMANIntAct14743216 details
RIPK3_HUMANDDX5_HUMANIntAct14743216 details
RIPK3_HUMANTCPH_HUMANIntAct14743216 details
RIPK3_HUMANWDR61_HUMANIntAct14743216 details
RIPK3_HUMANMYH10_HUMANIntAct14743216 details
RIPK3_HUMANPYR1_HUMANIntAct14743216 details
RIPK3_HUMANRUVB1_HUMANIntAct14743216 details
RIPK3_HUMANACTG_HUMANIntAct14743216 details
RIPK3_HUMANMPCP_HUMANIntAct14743216 details
RIPK3_HUMANTIM50_HUMANIntAct14743216 details
RIPK3_HUMANCLH1_HUMANIntAct14743216 details
RIPK3_HUMANGBB1_HUMANIntAct14743216 details
RIPK3_HUMANMYL6B_HUMANIntAct14743216 details
RIPK3_HUMANTBB2B_HUMANIntAct14743216 details
RIPK3_HUMANECHA_HUMANIntAct14743216 details
RIPK3_HUMANAIF1L_HUMANIntAct14743216 details
RIPK3_HUMANMYO6_HUMANIntAct14743216 details
RIPK3_HUMANCALM2_HUMANIntAct14743216 details
RIPK3_HUMANNONO_HUMANIntAct14743216 details
RIPK3_HUMANBASP1_HUMANIntAct14743216 details
RIPK3_HUMANTBB5_HUMANIntAct14743216 details
RIPK3_HUMANTBB4A_HUMANIntAct14743216 details
RIPK3_HUMANATD3A_HUMANIntAct14743216 details
RIPK3_HUMANMPRIP_HUMANIntAct14743216 details
RIPK3_HUMANEF1D_HUMANIntAct14743216 details
RIPK3_HUMANCYTSA_HUMANIntAct14743216 details
RIPK3_HUMANTPM3_HUMANIntAct14743216 details
RIPK3_HUMANRAI14_HUMANIntAct14743216 details
RIPK3_HUMANNEB2_HUMANIntAct14743216 details
RIPK3_HUMANFLNA_HUMANIntAct14743216 details
RIPK3_HUMANMYPT1_HUMANIntAct14743216 details
RIPK3_HUMANDAPK1_HUMANIntAct14743216 details
RIPK3_HUMANDDX3X_HUMANIntAct14743216 details
RIPK3_HUMANROA1_HUMANIntAct14743216 details
RIPK3_HUMANTCPB_HUMANIntAct14743216 details
RIPK3_HUMANTPM1_HUMANIntAct14743216 details
RIPK3_HUMANVIME_HUMANIntAct14743216 details
RIPK3_HUMANUBB_HUMANIntAct14743216 details
RIPK3_HUMANSPTB2_HUMANIntAct14743216 details
RIPK3_HUMANHS90A_HUMANIntAct14743216 details
RIPK3_HUMANPP1G_HUMANIntAct14743216 details
RIPK3_HUMANPP1B_HUMANIntAct14743216 details
RIPK3_HUMANPRKDC_HUMANIntAct14743216 details
RIPK3_HUMANMYL6_HUMANIntAct14743216 details
RIPK3_HUMANCAPZB_HUMANIntAct14743216 details
RIPK3_HUMANTBA3C_HUMANIntAct14743216 details
RIPK3_HUMANTBA3D_HUMANIntAct14743216 details
RIPK3_HUMANLIMA1_HUMANIntAct14743216 details
RIPK3_HUMANHS90B_HUMANIntAct14743216 details
RIPK3_HUMANML12A_HUMANIntAct14743216 details
RIPK3_HUMANGNAI3_HUMANIntAct14743216 details
RIPK3_HUMANRS27_HUMANIntAct14743216 details
RIPK3_HUMANGBG12_HUMANIntAct14743216 details
RIPK3_HUMANMYO1D_HUMANIntAct14743216 details
RIPK3_HUMANCASP8_HUMANBioGRID, IntAct19524512 19524513 22864571 30420664 details
RIPK3_HUMANFADD_HUMANBioGRID, IntAct19524513 21052097 22864571 26786097 27560715 30420664 details
RIPK3_HUMANZBP1_HUMANMINT19590578 details
RIPK3_HUMANTCAM1_HUMANBioGRID, HPRD15064760 details
RIPK3_HUMANTNR1A_HUMANBioGRID, HPRD10339433 details
RIPK3_HUMANPRKN_HUMANBioGRID31358971 details