Entity Details

Primary name BACE2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y5Z0
EntryNameBACE2_HUMAN
FullNameBeta-secretase 2
TaxID9606
Evidenceevidence at protein level
Length518
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesBACE2

GO terms

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GOName
GO:0004190 aspartic-type endopeptidase activity
GO:0005768 endosome
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0006508 proteolysis
GO:0006509 membrane protein ectodomain proteolysis
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016486 peptide hormone processing
GO:0031045 dense core granule
GO:0042593 glucose homeostasis
GO:0042985 negative regulation of amyloid precursor protein biosynthetic process
GO:0048143 astrocyte activation
GO:0050435 amyloid-beta metabolic process

Subcellular Location

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Subcellular Location
Cell membrane
Endoplasmic reticulum
Endosome
Golgi apparatus

Domains

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DomainNameCategoryType
IPR001461 Aspartic peptidase A1 familyFamilyFamily
IPR001969 Aspartic peptidase, active siteSiteActive site
IPR009119 Beta-secretase BACEFamilyFamily
IPR009121 Beta-secretase BACE2FamilyFamily
IPR021109 Aspartic peptidase domain superfamilyFamilyHomologous superfamily
IPR033121 Peptidase family A1 domainDomainDomain
IPR033874 Memapsin-likeDomainDomain

Diseases

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