Entity Details

Primary name OPHN1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO60890
EntryNameOPHN1_HUMAN
FullNameOligophrenin-1
TaxID9606
Evidenceevidence at protein level
Length802
SequenceStatuscomplete
DateCreated2002-07-11
DateModified2021-06-02

Ontological Relatives

GenesOPHN1

GO terms

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GOName
GO:0003779 actin binding
GO:0005096 GTPase activator activity
GO:0005543 phospholipid binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006930 substrate-dependent cell migration, cell extension
GO:0007165 signal transduction
GO:0007399 nervous system development
GO:0007411 axon guidance
GO:0015629 actin cytoskeleton
GO:0021707 cerebellar granule cell differentiation
GO:0021895 cerebral cortex neuron differentiation
GO:0030036 actin cytoskeleton organization
GO:0030100 regulation of endocytosis
GO:0030182 neuron differentiation
GO:0031175 neuron projection development
GO:0034329 cell junction assembly
GO:0035023 regulation of Rho protein signal transduction
GO:0035255 ionotropic glutamate receptor binding
GO:0043195 terminal bouton
GO:0043197 dendritic spine
GO:0045198 establishment of epithelial cell apical/basal polarity
GO:0048488 synaptic vesicle endocytosis
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051966 regulation of synaptic transmission, glutamatergic
GO:0098880 maintenance of postsynaptic specialization structure
GO:0098978 glutamatergic synapse
GO:0099149 regulation of postsynaptic neurotransmitter receptor internalization
GO:1901799 negative regulation of proteasomal protein catabolic process

Subcellular Location

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Subcellular Location
Cell junction
Cell projection
Cytoplasm

Domains

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DomainNameCategoryType
IPR000198 Rho GTPase-activating protein domainDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR008936 Rho GTPase activation proteinFamilyHomologous superfamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR027267 AH/BAR domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
OPHN1_HUMANRHOA_HUMANBioGRID, HPRD11998687 9582072 details
OPHN1_HUMANRAC1_HUMANBioGRID, HPRD11998687 9582072 details
OPHN1_HUMANCDC42_HUMANBioGRID, HPRD11998687 9582072 details