Entity Details

Primary name LX12B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO75342
EntryNameLX12B_HUMAN
FullNameArachidonate 12-lipoxygenase, 12R-type
TaxID9606
Evidenceevidence at protein level
Length701
SequenceStatuscomplete
DateCreated2001-01-11
DateModified2021-06-02

Ontological Relatives

GenesALOX12B

GO terms

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GOName
GO:0004052 arachidonate 12(S)-lipoxygenase activity
GO:0005506 iron ion binding
GO:0005829 cytosol
GO:0006497 protein lipidation
GO:0006665 sphingolipid metabolic process
GO:0010628 positive regulation of gene expression
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0016829 lyase activity
GO:0016853 isomerase activity
GO:0019369 arachidonic acid metabolic process
GO:0019372 lipoxygenase pathway
GO:0034440 lipid oxidation
GO:0043410 positive regulation of MAPK cascade
GO:0043651 linoleic acid metabolic process
GO:0046513 ceramide biosynthetic process
GO:0047677 arachidonate 8(R)-lipoxygenase activity
GO:0048471 perinuclear region of cytoplasm
GO:0051122 hepoxilin biosynthetic process
GO:0061436 establishment of skin barrier
GO:0070257 positive regulation of mucus secretion
GO:1990136 linoleate 9S-lipoxygenase activity

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000907 LipoxygenaseFamilyFamily
IPR001024 PLAT/LH2 domainDomainDomain
IPR001885 Lipoxygenase, mammalianFamilyFamily
IPR013819 Lipoxygenase, C-terminalDomainDomain
IPR020833 Lipoxygenase, iron binding siteSiteBinding site
IPR020834 Lipoxygenase, conserved siteSiteConserved site
IPR036226 Lipoxigenase, C-terminal domain superfamilyFamilyHomologous superfamily
IPR036392 PLAT/LH2 domain superfamilyFamilyHomologous superfamily
IPR042062 Lipoxygenase, vertebrates, PLAT domainDomainDomain

Diseases

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Interactions

4 interactions