Entity Details

Primary name TPA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP00750
EntryNameTPA_HUMAN
FullNameTissue-type plasminogen activator
TaxID9606
Evidenceevidence at protein level
Length562
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesPLAT

GO terms

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GOName
GO:0004252 serine-type endopeptidase activity
GO:0005102 signaling receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0006464 cellular protein modification process
GO:0006508 proteolysis
GO:0007596 blood coagulation
GO:0009986 cell surface
GO:0014909 smooth muscle cell migration
GO:0031639 plasminogen activation
GO:0042730 fibrinolysis
GO:0045861 negative regulation of proteolysis
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0051219 phosphoprotein binding
GO:0060468 prevention of polyspermy
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000001 KringleDomainDomain
IPR000083 Fibronectin, type IDomainDomain
IPR000742 EGF-like domainDomainDomain
IPR001254 Serine proteases, trypsin domainDomainDomain
IPR001314 Peptidase S1A, chymotrypsin familyFamilyFamily
IPR009003 Peptidase S1, PA clanFamilyHomologous superfamily
IPR013806 Kringle-like foldFamilyHomologous superfamily
IPR018056 Kringle, conserved siteSiteConserved site
IPR018114 Serine proteases, trypsin family, histidine active siteSiteActive site
IPR026280 Tissue plasminogen activatorFamilyFamily
IPR033116 Serine proteases, trypsin family, serine active siteSiteActive site
IPR034811 Tissue-type plasminogen activatorFamilyFamily
IPR038178 Kringle superfamilyFamilyHomologous superfamily
IPR043504 Peptidase S1, PA clan, chymotrypsin-like foldFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00513 Aminocaproic acidDrugbanksmall molecule
DB01088 IloprostDrugbanksmall molecule
DB06404 Human C1-esterase inhibitorDrugbankbiotech
DB07684 5-(DIMETHYLAMINO)-2-NAPHTHALENESULFONIC ACIDDrugbanksmall molecule
DB09213 DexibuprofenDrugbanksmall molecule
DB09228 Conestat alfaDrugbankbiotech

Interactions

30 interactions

InteractorPartnerSourcesPublicationsLink
TPA_HUMANPAI1_HUMANBioGRID, HPRD, MINT2110366 22449964 3090045 8607113 details
TPA_HUMANTPA_HUMANHPRD, MINT24506586 8613982 9268299 9434908 details
TPA_HUMANTETN_HUMANBioGRID, HPRD12694198 details
TPA_HUMANCALR_HUMANBioGRID, HPRD9359841 details
TPA_HUMANUROK_HUMANBioGRID, HPRD7721771 details
TPA_HUMANK2C8_HUMANBioGRID, HPRD9988531 details
TPA_HUMANANXA2_HUMANBioGRID, HPRD11978811 12468550 details
TPA_HUMANNEUS_HUMANBioGRID, HPRD12228252 12354288 details
TPA_HUMANIPSP_HUMANBioGRID, HPRD2551064 details
TPA_HUMANFIBA_HUMANBioGRID, HPRD11170397 3088041 details
TPA_HUMANLRP1_HUMANBioGRID, HPRD10632583 1502153 details
TPA_HUMANFA10_HUMANBioGRID, HPRD11371191 details
TPA_HUMANFINC_HUMANBioGRID8360181 details
TPA_HUMANLAMA1_HUMANBioGRID, HPRD8360181 details
TPA_HUMANPDGFC_HUMANBioGRID22035541 details
TPA_HUMANLAMA3_HUMANBioGRID, HPRD10956663 details
TPA_HUMANA4_HUMANBioGRID18925455 details
TPA_HUMANVDAC1_HUMANBioGRID23161549 details
TPA_HUMANIC1_HUMANBioGRID, HPRD, IntAct28514442 7586269 details
TPA_HUMANTHRB_HUMANBioGRID10543954 details
TPA_HUMANHMGB1_HUMANBioGRID, HPRD1909331 8366113 details
TPA_HUMANTERF2_HUMANBioGRID20811636 details
TPA_HUMANPOTE1_HUMANBioGRID20811636 details
TPA_HUMANPLMN_HUMANHPRD11928826 details
TPA_HUMANMK01_HUMANHPRD15861134 details
TPA_HUMANSPRC_HUMANHPRD2745554 details
TPA_HUMANMK03_HUMANHPRD15861134 details
TPA_HUMANLRP1B_HUMANHPRD11384978 details
TPA_HUMANCKAP4_HUMANHPRD12913003 details
TPA_HUMANNMDZ1_HUMANHPRD15448144 details