Entity Details

Primary name A1AT_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP01009
EntryNameA1AT_HUMAN
FullNameAlpha-1-antitrypsin
TaxID9606
Evidenceevidence at protein level
Length418
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesSERPINA1

GO terms

Show/Hide Table
GOName
GO:0002020 protease binding
GO:0002576 platelet degranulation
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0005794 Golgi apparatus
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
GO:0006953 acute-phase response
GO:0007596 blood coagulation
GO:0010951 negative regulation of endopeptidase activity
GO:0030134 COPII-coated ER to Golgi transport vesicle
GO:0031093 platelet alpha granule lumen
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0042802 identical protein binding
GO:0043231 intracellular membrane-bounded organelle
GO:0043312 neutrophil degranulation
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0048208 COPII vesicle coating
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:1904813 ficolin-1-rich granule lumen

Subcellular Location

Show/Hide Table
Subcellular Location
Endoplasmic reticulum
Secreted

Domains

Show/Hide Table
DomainNameCategoryType
IPR000215 Serpin familyFamilyFamily
IPR023795 Serpin, conserved siteSiteConserved site
IPR023796 Serpin domainDomainDomain
IPR036186 Serpin superfamilyFamilyHomologous superfamily
IPR042178 Serpin superfamily, domain 1FamilyHomologous superfamily
IPR042185 Serpin superfamily, domain 2FamilyHomologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB01593 ZincDrugbanksmall molecule
DB01998 2-[3,4-Dihydroxy-2-Hydroxymethyl-5-(2-Hydroxy-Nonyl)-Tetrahydro-Furan-2-Yloxy]-6-Hydroxymethyl-Tetra Hydro-Pyran-3,4,5-TriolDrugbanksmall molecule
DB03345 MercaptoethanolDrugbanksmall molecule
DB05481 Recombinant alpha 1-antitrypsinDrugbankbiotech
DB05961 PPL-100Drugbanksmall molecule
DB09130 CopperDrugbanksmall molecule
DB14007 Pentetic acidSwissprotsmall molecule
DB14487 Zinc acetateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule

Interactions

49 interactions

InteractorPartnerSourcesPublicationsLink
A1AT_HUMANELNE_HUMANBioGRID, HPRD, IntAct10867014 16321984 details
A1AT_HUMANA1AT_HUMANDIP, HPRD, IntAct, MINT11057674 18923394 21909074 22405009 2785270 6332197 6966283 6976274 6982267 6983488 details
A1AT_HUMANTFE2_HUMANIntAct10915743 details
A1AT_HUMANRAP2A_HUMANBioGRID, IntAct18624398 details
A1AT_HUMANATPG_HUMANBioGRID, IntAct21988832 details
A1AT_HUMANECHM_HUMANBioGRID, IntAct21988832 details
A1AT_HUMANSMAD4_HUMANBioGRID, IntAct21988832 details
A1AT_HUMANSDC2_HUMANBioGRID, IntAct21988832 details
A1AT_HUMANZN363_HUMANBioGRID, IntAct21988832 details
A1AT_HUMANGSDMB_HUMANBioGRID, IntAct21988832 details
A1AT_HUMANMAGB6_HUMANIntAct32814053 details
A1AT_HUMANPRTN3_HUMANBioGRID, HPRD12114510 details
A1AT_HUMANVKOR1_HUMANBioGRID21103663 details
A1AT_HUMANLTOR5_HUMANBioGRID23241634 details
A1AT_HUMANGLP1R_HUMANBioGRID28597972 details
A1AT_HUMANS13A1_HUMANBioGRID18407958 details
A1AT_HUMANKLK1_HUMANBioGRID3643793 details
A1AT_HUMANHS90A_HUMANBioGRID31273033 details
A1AT_HUMANATS4_HUMANHPRD16099106 details
A1AT_HUMANSSRA_HUMANBioGRID, MINT17380188 details
A1AT_HUMANCALX_HUMANBioGRID, MINT17380188 details
A1AT_HUMANKLK3_HUMANBioGRID, HPRD11317942 1702714 details
A1AT_HUMANDERL2_HUMANBioGRID, HPRD16449194 21909096 23867461 26565908 details
A1AT_HUMANDERL1_HUMANBioGRID21909096 23867461 26565908 29743537 details
A1AT_HUMANTERA_HUMANBioGRID21135095 28301499 details
A1AT_HUMANOS9_HUMANBioGRID18264092 19914915 21172656 24899641 details
A1AT_HUMANERLEC_HUMANBioGRID18264092 19917667 23356641 details
A1AT_HUMANBIP_HUMANBioGRID24899641 details
A1AT_HUMANFBX2_HUMANBioGRID26295339 details
A1AT_HUMANSYVN1_HUMANBioGRID28121484 29743537 details
A1AT_HUMANSQSTM_HUMANBioGRID28121484 details
A1AT_HUMANDERL3_HUMANBioGRID, HPRD16449193 26565908 details
A1AT_HUMANSRP54_HUMANBioGRID26565908 details
A1AT_HUMANTXND5_HUMANBioGRID29784879 details
A1AT_HUMANEDEM3_HUMANBioGRID29784879 details
A1AT_HUMANEDEM1_HUMANBioGRID30021839 details
A1AT_HUMANERGI3_HUMANBioGRID31142615 details
A1AT_HUMANLMAN1_HUMANBioGRID31142615 details
A1AT_HUMANMMP7_HUMANHPRD7980522 details
A1AT_HUMANTRY1_HUMANHPRD11057674 details
A1AT_HUMANTRY2_HUMANHPRD2610933 details
A1AT_HUMANMMP26_HUMANHPRD12119297 details
A1AT_HUMANTRY3_HUMANHPRD11057674 12860985 details
A1AT_HUMANCTRB1_HUMANHPRD6983488 details
A1AT_HUMANMMP11_HUMANHPRD7523394 details
A1AT_HUMANKLK5_HUMANHPRD12890555 details
A1AT_HUMANCELA1_HUMANHPRD1079736 6153632 6191979 details
A1AT_HUMANLRP1_HUMANHPRD15131125 details
A1AT_HUMANCATG_HUMANHPRD15131125 details