Entity Details

Primary name IGF2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP01344
EntryNameIGF2_HUMAN
FullNameInsulin-like growth factor II
TaxID9606
Evidenceevidence at protein level
Length180
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesIGF2

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001501 skeletal system development
GO:0001649 osteoblast differentiation
GO:0001701 in utero embryonic development
GO:0001892 embryonic placenta development
GO:0001934 positive regulation of protein phosphorylation
GO:0002576 platelet degranulation
GO:0005158 insulin receptor binding
GO:0005159 insulin-like growth factor receptor binding
GO:0005178 integrin binding
GO:0005179 hormone activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0006006 glucose metabolic process
GO:0006349 regulation of gene expression by genetic imprinting
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organism development
GO:0008083 growth factor activity
GO:0008284 positive regulation of cell population proliferation
GO:0008286 insulin receptor signaling pathway
GO:0009887 animal organ morphogenesis
GO:0031017 exocrine pancreas development
GO:0031056 regulation of histone modification
GO:0031093 platelet alpha granule lumen
GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase
GO:0040018 positive regulation of multicellular organism growth
GO:0042104 positive regulation of activated T cell proliferation
GO:0043085 positive regulation of catalytic activity
GO:0043410 positive regulation of MAPK cascade
GO:0043539 protein serine/threonine kinase activator activity
GO:0044267 cellular protein metabolic process
GO:0045725 positive regulation of glycogen biosynthetic process
GO:0045840 positive regulation of mitotic nuclear division
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046622 positive regulation of organ growth
GO:0046628 positive regulation of insulin receptor signaling pathway
GO:0048018 receptor ligand activity
GO:0048633 positive regulation of skeletal muscle tissue growth
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051146 striated muscle cell differentiation
GO:0051147 regulation of muscle cell differentiation
GO:0051148 negative regulation of muscle cell differentiation
GO:0051781 positive regulation of cell division
GO:0051897 positive regulation of protein kinase B signaling
GO:0060669 embryonic placenta morphogenesis
GO:0060720 spongiotrophoblast cell proliferation
GO:1905564 positive regulation of vascular endothelial cell proliferation
GO:2000467 positive regulation of glycogen (starch) synthase activity

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR013576 Insulin-like growth factor II E-peptide, C-terminalDomainDomain
IPR016179 Insulin-likeDomainDomain
IPR022334 Insulin-like growth factor IIFamilyFamily
IPR022350 Insulin-like growth factorFamilyFamily
IPR022352 Insulin familyFamilyFamily
IPR022353 Insulin, conserved siteSiteConserved site
IPR036438 Insulin-like superfamilyFamilyHomologous superfamily

Diseases

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Interactions

28 interactions

InteractorPartnerSourcesPublicationsLink
IGF2_HUMANMPRI_HUMANDIP, HPRD, MINT17850746 18046459 7797478 9722981 details
IGF2_HUMANCREL2_HUMANMINT21900206 details
IGF2_HUMANFAF1_HUMANBioGRID, MINT21900206 details
IGF2_HUMANNRK2_HUMANBioGRID, MINT21900206 details
IGF2_HUMANPGS2_HUMANmatrixdb24389353 details
IGF2_HUMANRBPMS_HUMANBioGRID, IntAct25416956 details
IGF2_HUMANGP152_HUMANBioGRID, IntAct32296183 details
IGF2_HUMANIBP1_HUMANBioGRID, DIP, HPRD, IntAct10810289 22578544 28514442 details
IGF2_HUMANIBP3_HUMANBioGRID, DIP, HPRD10407151 11600567 11749962 22578544 9446566 9497324 details
IGF2_HUMANIBP4_HUMANBioGRID, HPRD, IntAct31467278 9722589 details
IGF2_HUMANCCN3_HUMANBioGRID, HPRD10084601 details
IGF2_HUMANIBP7_HUMANBioGRID, HPRD8939990 details
IGF2_HUMANTRFE_HUMANBioGRID11749962 details
IGF2_HUMANVTNC_HUMANBioGRID, HPRD10342887 details
IGF2_HUMANIDE_HUMANBioGRID, HPRD1733942 details
IGF2_HUMANIBP6_HUMANBioGRID, HPRD7683646 details
IGF2_HUMANIBP5_HUMANBioGRID, HPRD9497324 details
IGF2_HUMANBAG6_HUMANBioGRID21900206 details
IGF2_HUMANPCSK4_HUMANBioGRID, HPRD16040806 details
IGF2_HUMANCLN5_HUMANBioGRID32296183 details
IGF2_HUMANTRI55_HUMANBioGRID31391242 details
IGF2_HUMANTRI63_HUMANBioGRID31391242 details
IGF2_HUMANPLMN_HUMANHPRD15642732 details
IGF2_HUMANCCN5_HUMANHPRD10358067 details
IGF2_HUMANIBP2_HUMANHPRD1714916 2465304 8781553 details
IGF2_HUMANIGF1R_HUMANHPRD9972281 details
IGF2_HUMANINSR_HUMANHPRD9722981 details
IGF2_HUMANGPC3_HUMANHPRD8589713 details