Entity Details

Primary name TNFA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP01375
EntryNameTNFA_HUMAN
FullNameTumor necrosis factor
TaxID9606
Evidenceevidence at protein level
Length233
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesTNF

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000165 MAPK cascade
GO:0000185 obsolete activation of MAPKKK activity
GO:0000187 obsolete activation of MAPK activity
GO:0000976 transcription cis-regulatory region binding
GO:0001774 microglial cell activation
GO:0001819 positive regulation of cytokine production
GO:0001891 phagocytic cup
GO:0001934 positive regulation of protein phosphorylation
GO:0001937 negative regulation of endothelial cell proliferation
GO:0002020 protease binding
GO:0002439 chronic inflammatory response to antigenic stimulus
GO:0002637 regulation of immunoglobulin production
GO:0002719 negative regulation of cytokine production involved in immune response
GO:0002876 positive regulation of chronic inflammatory response to antigenic stimulus
GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0005125 cytokine activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006006 glucose metabolic process
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006954 inflammatory response
GO:0006959 humoral immune response
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007254 JNK cascade
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009615 response to virus
GO:0009651 response to salt stress
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0010573 vascular endothelial growth factor production
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010693 negative regulation of alkaline phosphatase activity
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0010888 negative regulation of lipid storage
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016020 membrane
GO:0019221 cytokine-mediated signaling pathway
GO:0030198 extracellular matrix organization
GO:0030316 osteoclast differentiation
GO:0030730 sequestering of triglyceride
GO:0030866 cortical actin cytoskeleton organization
GO:0031334 positive regulation of protein-containing complex assembly
GO:0031622 positive regulation of fever generation
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032715 negative regulation of interleukin-6 production
GO:0032722 positive regulation of chemokine production
GO:0032724 positive regulation of fractalkine production
GO:0032729 positive regulation of interferon-gamma production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032991 protein-containing complex
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0034116 positive regulation of heterotypic cell-cell adhesion
GO:0035509 negative regulation of myosin-light-chain-phosphatase activity
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042802 identical protein binding
GO:0043065 positive regulation of apoptotic process
GO:0043068 positive regulation of programmed cell death
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043242 negative regulation of protein-containing complex disassembly
GO:0043243 positive regulation of protein-containing complex disassembly
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043406 positive regulation of MAP kinase activity
GO:0043491 protein kinase B signaling
GO:0043507 positive regulation of JUN kinase activity
GO:0043525 positive regulation of neuron apoptotic process
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:0045071 negative regulation of viral genome replication
GO:0045121 membrane raft
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045598 regulation of fat cell differentiation
GO:0045599 negative regulation of fat cell differentiation
GO:0045662 negative regulation of myoblast differentiation
GO:0045668 negative regulation of osteoblast differentiation
GO:0045672 positive regulation of osteoclast differentiation
GO:0045732 positive regulation of protein catabolic process
GO:0045785 positive regulation of cell adhesion
GO:0045860 positive regulation of protein kinase activity
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045930 negative regulation of mitotic cell cycle
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0045994 positive regulation of translational initiation by iron
GO:0046325 negative regulation of glucose import
GO:0046330 positive regulation of JNK cascade
GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT
GO:0048143 astrocyte activation
GO:0048566 embryonic digestive tract development
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050729 positive regulation of inflammatory response
GO:0050766 positive regulation of phagocytosis
GO:0050768 negative regulation of neurogenesis
GO:0050796 regulation of insulin secretion
GO:0050806 positive regulation of synaptic transmission
GO:0050807 regulation of synapse organization
GO:0050830 defense response to Gram-positive bacterium
GO:0050890 cognition
GO:0050901 leukocyte tethering or rolling
GO:0050995 negative regulation of lipid catabolic process
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0051044 positive regulation of membrane protein ectodomain proteolysis
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051173 positive regulation of nitrogen compound metabolic process
GO:0051222 positive regulation of protein transport
GO:0051384 response to glucocorticoid
GO:0051798 positive regulation of hair follicle development
GO:0051897 positive regulation of protein kinase B signaling
GO:0051966 regulation of synaptic transmission, glutamatergic
GO:0055037 recycling endosome
GO:0060252 positive regulation of glial cell proliferation
GO:0060557 positive regulation of vitamin D biosynthetic process
GO:0060559 positive regulation of calcidiol 1-monooxygenase activity
GO:0060664 epithelial cell proliferation involved in salivary gland morphogenesis
GO:0060693 regulation of branching involved in salivary gland morphogenesis
GO:0061044 negative regulation of vascular wound healing
GO:0061048 negative regulation of branching involved in lung morphogenesis
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070886 positive regulation of calcineurin-NFAT signaling cascade
GO:0071230 cellular response to amino acid stimulus
GO:0071316 cellular response to nicotine
GO:0071407 cellular response to organic cyclic compound
GO:0071550 death-inducing signaling complex assembly
GO:0071677 positive regulation of mononuclear cell migration
GO:0071803 positive regulation of podosome assembly
GO:0072577 endothelial cell apoptotic process
GO:0072659 protein localization to plasma membrane
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097527 necroptotic signaling pathway
GO:0150078 positive regulation of neuroinflammatory response
GO:0150129 positive regulation of interleukin-33 production
GO:1900017 positive regulation of cytokine production involved in inflammatory response
GO:1900222 negative regulation of amyloid-beta clearance
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1901647 positive regulation of synoviocyte proliferation
GO:1901671 positive regulation of superoxide dismutase activity
GO:1902004 positive regulation of amyloid-beta formation
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1903078 positive regulation of protein localization to plasma membrane
GO:1903140 regulation of establishment of endothelial barrier
GO:1903347 negative regulation of bicellular tight junction assembly
GO:1903721 positive regulation of I-kappaB phosphorylation
GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell
GO:1904999 positive regulation of leukocyte adhesion to arterial endothelial cell
GO:2000010 positive regulation of protein localization to cell surface
GO:2000272 negative regulation of signaling receptor activity
GO:2000304 positive regulation of ceramide biosynthetic process
GO:2000334 positive regulation of blood microparticle formation
GO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production
GO:2000351 regulation of endothelial cell apoptotic process
GO:2000377 regulation of reactive oxygen species metabolic process
GO:2001234 negative regulation of apoptotic signaling pathway
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Subcellular Location

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Subcellular Location
Cell membrane
Membrane
Secreted

Domains

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DomainNameCategoryType
IPR002959 Tumour necrosis factor alphaFamilyFamily
IPR006052 Tumour necrosis factor domainDomainDomain
IPR006053 Tumour necrosis factorFamilyFamily
IPR008983 Tumour necrosis factor-like domain superfamilyFamilyHomologous superfamily
IPR021184 Tumour necrosis factor, conserved siteSiteConserved site

Diseases

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Drugs

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DrugNameSourceType
DB00005 EtanerceptDrugbankbiotech
DB00051 AdalimumabDrugbankbiotech
DB00065 InfliximabDrugbankbiotech
DB00608 ChloroquineDrugbanksmall molecule
DB00668 EpinephrineDrugbanksmall molecule
DB00852 PseudoephedrineDrugbanksmall molecule
DB01041 ThalidomideDrugbanksmall molecule
DB01296 GlucosamineDrugbanksmall molecule
DB01407 ClenbuterolDrugbanksmall molecule
DB01411 PranlukastDrugbanksmall molecule
DB01427 AmrinoneDrugbanksmall molecule
DB04956 AfelimomabDrugbankbiotech
DB05017 YSIL6Drugbanksmall molecule
DB05207 SD118Drugbanksmall molecule
DB05218 PN0621Drugbankbiotech
DB05303 OMS-103HPDrugbanksmall molecule
DB05412 TalmapimodDrugbanksmall molecule
DB05470 VX-702Drugbanksmall molecule
DB05513 AtiprimodDrugbanksmall molecule
DB05744 CRx-139Drugbanksmall molecule
DB05758 CYT007-TNFQbDrugbankbiotech
DB05767 AndrographolideDrugbanksmall molecule
DB05869 Ethyl pyruvateDrugbanksmall molecule
DB05879 AME-527Drugbankbiotech
DB05968 PR-104Drugbanksmall molecule
DB05992 PlinabulinDrugbanksmall molecule
DB06444 DexanabinolDrugbanksmall molecule
DB06495 OnerceptDrugbankbiotech
DB06674 GolimumabDrugbankbiotech
DB08904 Certolizumab pegolDrugbankbiotech
DB08910 PomalidomideDrugbanksmall molecule
DB09221 PolaprezincDrugbanksmall molecule
DB10770 Foreskin fibroblast (neonatal)Drugbankbiotech
DB10772 Foreskin keratinocyte (neonatal)Drugbankbiotech
DB11752 Bryostatin 1Drugbanksmall molecule
DB11967 BinimetinibDrugbanksmall molecule
DB12140 DilmapimodDrugbanksmall molecule
DB13751 Glycyrrhizic acidDrugbanksmall molecule

Interactions

105 interactions

InteractorPartnerSourcesPublicationsLink
TNFA_HUMANTNR1A_HUMANBioGRID, DIP, HPRD, IntAct, MINT10634209 11448951 12753742 12887920 1310388 14743216 15173183 15485837 19084540 20080539 20103630 2170559 22028622 22099304 22675546 22801493 23032187 23746843 23955153 24070898 24726327 24980434 25241761 25911380 26186194 26670046 27307491 27545878 27560715 2848815 28514442 30420664 31898971 8182064 8288897 8805640 9568681 details
TNFA_HUMANTNR1B_HUMANBioGRID, HPRD, IntAct, MINT11448951 1310388 14743216 15173183 15485837 19084540 2158863 24070898 7664431 7930591 7966397 8182064 8805640 9568681 details
TNFA_HUMANTRADD_HUMANBioGRID, DIP, IntAct12753742 12887920 15485837 16603398 20005846 21822306 22099304 23732909 23955153 24980434 27307491 27458237 27545878 30561431 details
TNFA_HUMANRIPK1_HUMANBioGRID, DIP, InnateDB, IntAct, MINT12753742 12887920 16603398 20005846 21331077 21620750 22028622 22099304 22675546 23032187 23104095 23815148 23955153 24726327 24980434 25911380 26670046 27307491 27458237 27545878 27560715 30420664 31898971 details
TNFA_HUMANTNAP3_HUMANBioGRID, IntAct, MINT22099304 23032186 23032187 25911380 26670046 27307491 27545878 30561431 details
TNFA_HUMANTNFA_HUMANBioGRID, DIP, HPRD, MINT1331108 15173183 19838188 23815148 2551905 2922050 3351931 3417634 8869635 9442056 9488135 details
TNFA_HUMANSTX1A_HUMANBioGRID, IntAct32296183 details
TNFA_HUMANKASH5_HUMANBioGRID, IntAct32296183 details
TNFA_HUMANTMPS2_HUMANBioGRID, IntAct32296183 details
TNFA_HUMANCLC10_HUMANBioGRID, IntAct32296183 details
TNFA_HUMANRN19B_HUMANBioGRID, IntAct32296183 details
TNFA_HUMANCJ067_HUMANBioGRID, IntAct32296183 details
TNFA_HUMANPANX1_HUMANBioGRID, IntAct32296183 details
TNFA_HUMANPP4P2_HUMANBioGRID, IntAct32296183 details
TNFA_HUMANSTOM_HUMANBioGRID, IntAct32296183 details
TNFA_HUMANFNDC9_HUMANBioGRID, IntAct32296183 details
TNFA_HUMANBTNL9_HUMANBioGRID, IntAct32296183 details
TNFA_HUMANFFAR2_HUMANBioGRID, IntAct32296183 details
TNFA_HUMANF209A_HUMANBioGRID, IntAct32296183 details
TNFA_HUMANVISTA_HUMANBioGRID, IntAct32296183 details
TNFA_HUMANLRRT2_HUMANBioGRID, IntAct32296183 details
TNFA_HUMANPAGE1_HUMANBioGRID, IntAct32296183 details
TNFA_HUMANZNT4_HUMANBioGRID, IntAct32296183 details
TNFA_HUMANPKHO1_HUMANBioGRID, IntAct32296183 details
TNFA_HUMANZCH12_HUMANBioGRID, IntAct32296183 details
TNFA_HUMANCLD7_HUMANBioGRID, IntAct32296183 details
TNFA_HUMANSSMM1_HUMANBioGRID, IntAct32296183 details
TNFA_HUMANLRC25_HUMANBioGRID, IntAct32296183 details
TNFA_HUMANCR3L1_HUMANBioGRID, IntAct32296183 details
TNFA_HUMANB2L13_HUMANBioGRID, IntAct32296183 details
TNFA_HUMANSGCB_HUMANBioGRID, IntAct32296183 details
TNFA_HUMANUT2_HUMANBioGRID, IntAct32296183 details
TNFA_HUMANMRM3_HUMANBioGRID, IntAct32296183 details
TNFA_HUMANAQP3_HUMANBioGRID, IntAct32296183 details
TNFA_HUMANCCD70_HUMANBioGRID, IntAct32296183 details
TNFA_HUMANNB5R3_HUMANBioGRID, IntAct32296183 details
TNFA_HUMANCC107_HUMANBioGRID, IntAct32296183 details
TNFA_HUMANA4_HUMANIntAct32814053 details
TNFA_HUMANPGS1_HUMANBioGRID, HPRD12387878 details
TNFA_HUMANPGS2_HUMANBioGRID, HPRD12387878 details
TNFA_HUMANPO2F1_HUMANBioGRID12019209 27465491 details
TNFA_HUMANTTP_HUMANBioGRID15014438 21784977 30917308 31679460 details
TNFA_HUMANFYN_HUMANBioGRID9230816 details
TNFA_HUMANLYN_HUMANBioGRID9230816 details
TNFA_HUMANIKBA_HUMANBioGRID7739525 details
TNFA_HUMANS61A1_HUMANBioGRID24497544 details
TNFA_HUMANLMNA_HUMANBioGRID24623722 details
TNFA_HUMANBIRC2_HUMANBioGRID, IntAct, MINT12887920 20005846 21822306 23815148 25911380 27307491 30561431 details
TNFA_HUMANTRAF2_HUMANBioGRID, DIP, HPRD, IntAct, MINT12887920 15485837 16603398 20005846 21822306 23955153 24980434 25911380 27307491 27545878 30420664 30561431 details
TNFA_HUMANERIC2_HUMANIntAct20195357 details
TNFA_HUMANRS18_HUMANBioGRID, IntAct20195357 27545878 details
TNFA_HUMANTICN1_HUMANIntAct20195357 details
TNFA_HUMANNFL_HUMANIntAct20195357 details
TNFA_HUMANNT5D3_HUMANIntAct20195357 details
TNFA_HUMANLIN54_HUMANIntAct20195357 details
TNFA_HUMANSCG2_HUMANIntAct20195357 details
TNFA_HUMANSLU7_HUMANIntAct20195357 details
TNFA_HUMANSPRL1_HUMANIntAct20195357 details
TNFA_HUMANAT2A2_HUMANIntAct20195357 details
TNFA_HUMANF10A1_HUMANIntAct20195357 details
TNFA_HUMANSC16A_HUMANIntAct20195357 details
TNFA_HUMANCALM2_HUMANBioGRID, IntAct20195357 27545878 details
TNFA_HUMANSYCC_HUMANIntAct20195357 details
TNFA_HUMANPTPRZ_HUMANIntAct20195357 details
TNFA_HUMANNEMO_HUMANBioGRID, InnateDB, IntAct, MINT16603398 20005846 23032186 23032187 23104095 26670046 27307491 27560715 30420664 30561431 details
TNFA_HUMANHOIL1_HUMANBioGRID, DIP, InnateDB, MINT20005846 23032186 23104095 23955153 25911380 26670046 27307491 27545878 30420664 31898971 details
TNFA_HUMANRNF31_HUMANBioGRID, DIP, IntAct, MINT20005846 23032186 23032187 23732909 23746843 23955153 24726327 26670046 27307491 27545878 30420664 30561431 31898971 32019898 details
TNFA_HUMANSHRPN_HUMANBioGRID, DIP, InnateDB, IntAct, MINT23032186 23032187 23104095 23955153 26670046 27307491 27458237 27545878 27560715 30420664 30561431 31898971 details
TNFA_HUMANTNIP1_HUMANBioGRID, IntAct20005846 27307491 27545878 30561431 details
TNFA_HUMANRBP1_HUMANBioGRID12887920 details
TNFA_HUMANTNR6_HUMANBioGRID12753742 details
TNFA_HUMANCAV1_HUMANBioGRID12753742 details
TNFA_HUMANTBK1_HUMANBioGRID15485837 27307491 27545878 30420664 details
TNFA_HUMANCDC42_HUMANBioGRID15485837 details
TNFA_HUMANFBW1A_HUMANBioGRID15485837 details
TNFA_HUMANFBW1B_HUMANBioGRID15485837 details
TNFA_HUMANIKKA_HUMANBioGRID20005846 27307491 27545878 details
TNFA_HUMANIKKB_HUMANBioGRID16603398 20005846 27307491 27545878 details
TNFA_HUMANTAB1_HUMANBioGRID20005846 27307491 27545878 details
TNFA_HUMANTAB2_HUMANBioGRID16603398 20005846 27307491 27545878 details
TNFA_HUMANUBC_HUMANBioGRID20005846 24980434 27307491 27545878 details
TNFA_HUMANM3K7_HUMANBioGRID16603398 27307491 27545878 details
TNFA_HUMANAGO2_HUMANBioGRID21562054 27545878 details
TNFA_HUMANOPTN_HUMANBioGRID22675546 27307491 details
TNFA_HUMANOTUL_HUMANBioGRID24726327 27307491 details
TNFA_HUMANRNF8_HUMANBioGRID24980434 details
TNFA_HUMANUBE2N_HUMANBioGRID24980434 details
TNFA_HUMANFADD_HUMANBioGRID24980434 details
TNFA_HUMANCASP8_HUMANBioGRID24980434 details
TNFA_HUMANRAB5A_HUMANBioGRID24980434 details
TNFA_HUMANLAMP2_HUMANBioGRID24980434 details
TNFA_HUMANCYLD_HUMANBioGRID26670046 27307491 27458237 27545878 31898971 details
TNFA_HUMANSPAT2_HUMANBioGRID27307491 27458237 27545878 details
TNFA_HUMANIKKE_HUMANBioGRID27307491 30420664 details
TNFA_HUMANTANK_HUMANBioGRID27307491 30420664 details
TNFA_HUMANAZI2_HUMANBioGRID30420664 details
TNFA_HUMANTBKB1_HUMANBioGRID30420664 details
TNFA_HUMANPACRG_HUMANBioGRID32019898 details
TNFA_HUMANPRTN3_HUMANHPRD10339575 details
TNFA_HUMANMMP17_HUMANHPRD10799478 details
TNFA_HUMANADAM9_HUMANHPRD9920899 details
TNFA_HUMANADA17_HUMANHPRD10799478 12135369 details
TNFA_HUMANCSF1_HUMANHPRD8336080 details
TNFA_HUMANIFNG_HUMANHPRD3139842 details
TNFA_HUMANPDK1L_HUMANHPRD8597870 details