Entity Details

Primary name OSTCN_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP02818
EntryNameOSTCN_HUMAN
FullNameOsteocalcin
TaxID9606
Evidenceevidence at protein level
Length100
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesBGLAP

GO terms

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GOName
GO:0001501 skeletal system development
GO:0001649 osteoblast differentiation
GO:0002076 osteoblast development
GO:0005198 structural molecule activity
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005788 endoplasmic reticulum lumen
GO:0005791 rough endoplasmic reticulum
GO:0005796 Golgi lumen
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
GO:0007155 cell adhesion
GO:0007569 cell aging
GO:0008147 structural constituent of bone
GO:0009612 response to mechanical stimulus
GO:0009629 response to gravity
GO:0010043 response to zinc ion
GO:0014823 response to activity
GO:0030282 bone mineralization
GO:0030425 dendrite
GO:0030500 regulation of bone mineralization
GO:0031982 vesicle
GO:0032571 response to vitamin K
GO:0033280 response to vitamin D
GO:0033574 response to testosterone
GO:0033594 response to hydroxyisoflavone
GO:0042476 odontogenesis
GO:0042493 response to drug
GO:0043204 perikaryon
GO:0043627 response to estrogen
GO:0045124 regulation of bone resorption
GO:0045471 response to ethanol
GO:0045670 regulation of osteoclast differentiation
GO:0046848 hydroxyapatite binding
GO:0051384 response to glucocorticoid
GO:0060348 bone development
GO:0071305 cellular response to vitamin D
GO:0071363 cellular response to growth factor stimulus
GO:1900076 regulation of cellular response to insulin stimulus

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domainDomainDomain
IPR002384 Osteocalcin/matrix Gla proteinFamilyFamily
IPR035972 Gamma-carboxyglutamic acid-rich (GLA) domain superfamilyFamilyHomologous superfamily
IPR039176 OsteocalcinFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB00170 MenadioneDrugbanksmall molecule
DB01022 PhylloquinoneDrugbanksmall molecule
DB03847 gamma-carboxy-L-glutamic acidDrugbanksmall molecule
DB05260 Gallium nitrateDrugbanksmall molecule