Entity Details

Primary name TYSY_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP04818
EntryNameTYSY_HUMAN
FullNameThymidylate synthase
TaxID9606
Evidenceevidence at protein level
Length313
SequenceStatuscomplete
DateCreated1987-08-13
DateModified2021-06-02

Ontological Relatives

GenesTYMS

GO terms

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GOName
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000900 translation repressor activity, mRNA regulatory element binding
GO:0004799 thymidylate synthase activity
GO:0005542 folic acid binding
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0006231 dTMP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0007568 aging
GO:0007623 circadian rhythm
GO:0009636 response to toxic substance
GO:0015949 nucleobase-containing small molecule interconversion
GO:0017148 negative regulation of translation
GO:0019048 modulation by virus of host process
GO:0019860 uracil metabolic process
GO:0032259 methylation
GO:0032570 response to progesterone
GO:0033189 response to vitamin A
GO:0034097 response to cytokine
GO:0035999 tetrahydrofolate interconversion
GO:0042493 response to drug
GO:0042803 protein homodimerization activity
GO:0045471 response to ethanol
GO:0046683 response to organophosphorus
GO:0048589 developmental growth
GO:0051216 cartilage development
GO:0051384 response to glucocorticoid
GO:0051593 response to folic acid
GO:0060574 intestinal epithelial cell maturation
GO:0071897 DNA biosynthetic process
GO:0097421 liver regeneration
GO:1990825 sequence-specific mRNA binding

Subcellular Location

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Subcellular Location
Cytoplasm
Mitochondrion
Mitochondrion inner membrane
Mitochondrion matrix
Nucleus

Domains

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DomainNameCategoryType
IPR000398 Thymidylate synthaseFamilyFamily
IPR020940 Thymidylate synthase, active siteSiteActive site
IPR023451 Thymidylate synthase/dCMP hydroxymethylase domainDomainDomain
IPR036926 Thymidylate synthase/dCMP hydroxymethylase superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00293 RaltitrexedDrugbanksmall molecule
DB00322 FloxuridineDrugbanksmall molecule
DB00432 TrifluridineDrugbanksmall molecule
DB00441 GemcitabineDrugbanksmall molecule
DB00544 FluorouracilDrugbanksmall molecule
DB00563 MethotrexateDrugbanksmall molecule
DB00642 PemetrexedDrugbanksmall molecule
DB01101 CapecitabineDrugbanksmall molecule
DB01643 Thymidine monophosphateDrugbanksmall molecule
DB03541 10-Propargyl-5,8-Dideazafolic AcidDrugbanksmall molecule
DB03800 Deoxyuridine monophosphateDrugbanksmall molecule
DB04530 S,S-(2-Hydroxyethyl)ThiocysteineDrugbanksmall molecule
DB05116 ThymectacinDrugbanksmall molecule
DB05308 ANX-510Drugbanksmall molecule
DB05457 OSI-7904LDrugbanksmall molecule
DB06813 PralatrexateDrugbanksmall molecule
DB07577 2,4-Diamino-5-phenyl-6-ethylpyrimidineDrugbanksmall molecule
DB08478 N-[2-Chloro-5-(trifluoromethyl)phenyl]imidodicarbonimidic diamideDrugbanksmall molecule
DB08479 N-(3,5-dimethoxyphenyl)imidodicarbonimidic diamideDrugbanksmall molecule
DB08734 6,6-DIMETHYL-1-[3-(2,4,5-TRICHLOROPHENOXY)PROPOXY]-1,6-DIHYDRO-1,3,5-TRIAZINE-2,4-DIAMINEDrugbanksmall molecule
DB09256 TegafurDrugbanksmall molecule
DB09327 Tegafur-uracilDrugbanksmall molecule