Entity Details

Primary name CY24B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP04839
EntryNameCY24B_HUMAN
FullNameCytochrome b-245 heavy chain
TaxID9606
Evidenceevidence at protein level
Length570
SequenceStatuscomplete
DateCreated1987-08-13
DateModified2021-06-02

Ontological Relatives

GenesCYBB

GO terms

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GOName
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0005244 voltage-gated ion channel activity
GO:0005635 nuclear envelope
GO:0005789 endoplasmic reticulum membrane
GO:0005791 rough endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006801 superoxide metabolic process
GO:0006952 defense response
GO:0006954 inflammatory response
GO:0007584 response to nutrient
GO:0016175 superoxide-generating NAD(P)H oxidase activity
GO:0020037 heme binding
GO:0022900 electron transport chain
GO:0030425 dendrite
GO:0030670 phagocytic vesicle membrane
GO:0032760 positive regulation of tumor necrosis factor production
GO:0034599 cellular response to oxidative stress
GO:0034765 regulation of ion transmembrane transport
GO:0035579 specific granule membrane
GO:0042493 response to drug
GO:0042554 superoxide anion generation
GO:0043020 NADPH oxidase complex
GO:0043025 neuronal cell body
GO:0043312 neutrophil degranulation
GO:0045087 innate immune response
GO:0045454 cell redox homeostasis
GO:0045730 respiratory burst
GO:0045766 positive regulation of angiogenesis
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0050660 flavin adenine dinucleotide binding
GO:0070821 tertiary granule membrane
GO:0071276 cellular response to cadmium ion
GO:0071361 cellular response to ethanol
GO:0097038 perinuclear endoplasmic reticulum
GO:0097411 hypoxia-inducible factor-1alpha signaling pathway
GO:1904044 response to aldosterone
GO:1904845 cellular response to L-glutamine
GO:1990776 response to angiotensin

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000778 Cytochrome b245, heavy chainFamilyFamily
IPR013112 FAD-binding 8DomainDomain
IPR013121 Ferric reductase, NAD binding domainDomainDomain
IPR013130 Ferric reductase transmembrane component-like domainDomainDomain
IPR017927 FAD-binding domain, ferredoxin reductase-typeDomainDomain
IPR017938 Riboflavin synthase-like beta-barrelFamilyHomologous superfamily
IPR039261 Ferredoxin-NADP reductase (FNR), nucleotide-binding domainFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00514 DextromethorphanDrugbanksmall molecule