Entity Details

Primary name LIPL_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP06858
EntryNameLIPL_HUMAN
FullNameLipoprotein lipase
TaxID9606
Evidenceevidence at protein level
Length475
SequenceStatuscomplete
DateCreated1988-01-01
DateModified2021-06-02

Ontological Relatives

GenesLPL

GO terms

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GOName
GO:0001523 retinoid metabolic process
GO:0004465 lipoprotein lipase activity
GO:0004620 phospholipase activity
GO:0004806 triglyceride lipase activity
GO:0005102 signaling receptor binding
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0006631 fatty acid metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0006641 triglyceride metabolic process
GO:0006644 phospholipid metabolic process
GO:0008201 heparin binding
GO:0008970 phospholipase A1 activity
GO:0009409 response to cold
GO:0009617 response to bacterium
GO:0009749 response to glucose
GO:0009986 cell surface
GO:0010744 positive regulation of macrophage derived foam cell differentiation
GO:0010884 positive regulation of lipid storage
GO:0010886 positive regulation of cholesterol storage
GO:0010890 positive regulation of sequestering of triglyceride
GO:0016042 lipid catabolic process
GO:0016298 lipase activity
GO:0017129 triglyceride binding
GO:0019432 triglyceride biosynthetic process
GO:0019433 triglyceride catabolic process
GO:0031670 cellular response to nutrient
GO:0032722 positive regulation of chemokine production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0034185 apolipoprotein binding
GO:0034361 very-low-density lipoprotein particle
GO:0034371 chylomicron remodeling
GO:0034372 very-low-density lipoprotein particle remodeling
GO:0042493 response to drug
GO:0042627 chylomicron
GO:0042632 cholesterol homeostasis
GO:0042803 protein homodimerization activity
GO:0043395 heparan sulfate proteoglycan binding
GO:0043495 protein-membrane adaptor activity
GO:0045600 positive regulation of fat cell differentiation
GO:0050729 positive regulation of inflammatory response
GO:0051004 regulation of lipoprotein lipase activity
GO:0052739 phosphatidylserine 1-acylhydrolase activity
GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity
GO:0055096 low-density lipoprotein particle mediated signaling
GO:0070328 triglyceride homeostasis
GO:0071398 cellular response to fatty acid
GO:0071813 lipoprotein particle binding
GO:1900077 negative regulation of cellular response to insulin stimulus
GO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production

Subcellular Location

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Subcellular Location
Cell membrane
Secreted

Domains

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DomainNameCategoryType
IPR000734 Triacylglycerol lipase familyFamilyFamily
IPR001024 PLAT/LH2 domainDomainDomain
IPR002330 Lipoprotein lipaseFamilyFamily
IPR013818 Lipase/vitellogeninDomainDomain
IPR016272 Lipase, LIPH-typeFamilyFamily
IPR029058 Alpha/Beta hydrolase foldFamilyHomologous superfamily
IPR033906 Lipase, N-terminalDomainDomain
IPR036392 PLAT/LH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB06439 TyloxapolDrugbanksmall molecule
DB09568 Omega-3-carboxylic acidsDrugbanksmall molecule
DB13751 Glycyrrhizic acidDrugbanksmall molecule
DB13928 SemaglutideDrugbanksmall molecule

Interactions

34 interactions

InteractorPartnerSourcesPublicationsLink
LIPL_HUMANCSN6_HUMANBioGRID, HPRD, IntAct16169070 details
LIPL_HUMANCE126_HUMANBioGRID, HPRD, IntAct16169070 details
LIPL_HUMANLC7L2_HUMANBioGRID, HPRD, IntAct16169070 details
LIPL_HUMANPTN4_HUMANBioGRID, HPRD, IntAct16169070 details
LIPL_HUMANASCC2_HUMANBioGRID, HPRD, IntAct16169070 details
LIPL_HUMANUBE2Z_HUMANBioGRID, HPRD, IntAct16169070 details
LIPL_HUMANRL18A_HUMANBioGRID, HPRD, IntAct16169070 details
LIPL_HUMANCCND1_HUMANBioGRID, IntAct21988832 details
LIPL_HUMANSORT_HUMANbhf-ucl10085125 details
LIPL_HUMANHDBP1_HUMANbhf-ucl, UniProt20124439 30559189 details
LIPL_HUMANAPOA5_HUMANbhf-ucl15178420 details
LIPL_HUMANANGL4_HUMANUniProt19318355 details
LIPL_HUMANANGL3_HUMANUniProt19318355 details
LIPL_HUMANNDKM_HUMANIntAct32814053 details
LIPL_HUMANCCD26_HUMANIntAct32814053 details
LIPL_HUMANT185A_HUMANIntAct32814053 details
LIPL_HUMANSLN12_HUMANIntAct32814053 details
LIPL_HUMANPSMD9_HUMANIntAct32814053 details
LIPL_HUMANTGON2_HUMANIntAct32814053 details
LIPL_HUMANANM5_HUMANIntAct32814053 details
LIPL_HUMANEI2BD_HUMANIntAct32814053 details
LIPL_HUMANSNX12_HUMANIntAct32814053 details
LIPL_HUMANVKORL_HUMANIntAct32814053 details
LIPL_HUMANEMD_HUMANBioGRID12755701 details
LIPL_HUMANLRP2_HUMANBioGRID, HPRD7686151 details
LIPL_HUMANVLDLR_HUMANBioGRID, HPRD7592875 details
LIPL_HUMANLRP1_HUMANBioGRID, HPRD1281473 7510694 7989348 details
LIPL_HUMANA4_HUMANBioGRID21832049 details
LIPL_HUMANLIPL_HUMANBioGRID, HPRD12740382 14570890 details
LIPL_HUMANT22D2_HUMANBioGRID27337956 details
LIPL_HUMANCALR_HUMANBioGRID, HPRD12740382 details
LIPL_HUMANLMF1_HUMANBioGRID19783858 details
LIPL_HUMANAPOC2_HUMANHPRD10727238 11579204 details
LIPL_HUMANCETP_HUMANHPRD9374130 details