Entity Details

Primary name SYEP_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP07814
EntryNameSYEP_HUMAN
FullNameBifunctional glutamate/proline--tRNA ligase
TaxID9606
Evidenceevidence at protein level
Length1512
SequenceStatuscomplete
DateCreated1988-08-01
DateModified2021-06-02

Ontological Relatives

GenesEPRS1

GO terms

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GOName
GO:0004818 glutamate-tRNA ligase activity
GO:0004827 proline-tRNA ligase activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006418 tRNA aminoacylation for protein translation
GO:0006424 glutamyl-tRNA aminoacylation
GO:0006433 prolyl-tRNA aminoacylation
GO:0008270 zinc ion binding
GO:0016020 membrane
GO:0017101 aminoacyl-tRNA synthetase multienzyme complex
GO:0017148 negative regulation of translation
GO:0032869 cellular response to insulin stimulus
GO:0035613 RNA stem-loop binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0051020 GTPase binding
GO:0065003 protein-containing complex assembly
GO:0071346 cellular response to interferon-gamma
GO:0097452 GAIT complex
GO:0140212 regulation of long-chain fatty acid import into cell
GO:1990904 ribonucleoprotein complex

Subcellular Location

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Subcellular Location
Cytoplasm
Membrane

Domains

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DomainNameCategoryType
IPR000738 WHEP-TRS domainDomainDomain
IPR000924 Glutamyl/glutaminyl-tRNA synthetaseFamilyFamily
IPR001412 Aminoacyl-tRNA synthetase, class I, conserved siteSiteConserved site
IPR002314 Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)DomainDomain
IPR004046 Glutathione S-transferase, C-terminalDomainDomain
IPR004154 Anticodon-bindingDomainDomain
IPR004499 Proline-tRNA ligase, class IIa, archaeal-typeFamilyFamily
IPR004526 Glutamyl-tRNA synthetase, archaeal/eukaryotic cytosolicFamilyFamily
IPR006195 Aminoacyl-tRNA synthetase, class IIDomainDomain
IPR009068 S15/NS1, RNA-bindingFamilyHomologous superfamily
IPR011035 Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain superfamilyFamilyHomologous superfamily
IPR014729 Rossmann-like alpha/beta/alpha sandwich foldFamilyHomologous superfamily
IPR016061 Proline-tRNA ligase, class II, C-terminalDomainDomain
IPR017449 Prolyl-tRNA synthetase, class IIFamilyHomologous superfamily
IPR020056 Ribosomal protein L25/Gln-tRNA synthetase, N-terminalFamilyHomologous superfamily
IPR020058 Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domainDomainDomain
IPR020059 Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domainDomainDomain
IPR033721 Prolyl-tRNA synthetase, catalytic domainDomainDomain
IPR036282 Glutathione S-transferase, C-terminal domain superfamilyFamilyHomologous superfamily
IPR036621 Anticodon-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
617951 OMIMLeukodystrophy, hypomyelinating, 15 (HLD15)An autosomal recessive disorder characterized by hypomyelinating leukodystrophy with thinning of the corpus callosum. Clinical features include motor and cognitive impairment appearing in the first or second decade of life, dystonia, ataxia, spasticity, and dysphagia. Most patients develop severe optic atrophy, and some have hearing loss. The disease may be caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00142 Glutamic acidDrugbanksmall molecule
DB00172 ProlineDrugbanksmall molecule
DB02510 5'-O-(L-Prolylsulfamoyl)adenosineDrugbanksmall molecule
DB02684 5'-O-(L-Cysteinylsulfamoyl)adenosineDrugbanksmall molecule
DB03376 5'-O-(N-(Alanyl)sulfamoyl)adenosineDrugbanksmall molecule

Interactions

40 interactions

InteractorPartnerSourcesPublicationsLink
SYEP_HUMANSYIC_HUMANBioGRID, HPRD, IntAct, MINT, UniProt10913161 11142386 22863883 22939629 26344197 30021884 9556618 details
SYEP_HUMANHS90A_HUMANBioGRID, HPRD, MINT10913161 details
SYEP_HUMANARL4D_HUMANBioGRID, HPRD, IntAct16169070 details
SYEP_HUMANNELFD_HUMANBioGRID, HPRD, IntAct16169070 details
SYEP_HUMANEF1D_HUMANBioGRID, IntAct20195357 details
SYEP_HUMANSYRC_HUMANBioGRID, HPRD, IntAct22939629 26344197 28514442 31536960 9556618 details
SYEP_HUMANTAB1_HUMANBioGRID, MINT21900206 details
SYEP_HUMANESR1_HUMANBioGRID, IntAct20348541 25604459 details
SYEP_HUMANDUX4_HUMANBioGRID, IntAct26816005 details
SYEP_HUMANHSC20_HUMANBioGRID, DIP, IntAct24606901 28380382 details
SYEP_HUMANSYEP_HUMANDIP23263184 details
SYEP_HUMANNEDD4_HUMANBioGRID16055720 details
SYEP_HUMANCDC42_HUMANBioGRID22863883 31478661 details
SYEP_HUMANPTEN_HUMANBioGRID31685992 details
SYEP_HUMANSUMO2_HUMANBioGRID32786267 details
SYEP_HUMANIKBB_HUMANIntAct14743216 details
SYEP_HUMANIKBE_HUMANIntAct14743216 details
SYEP_HUMANIKKB_HUMANIntAct14743216 details
SYEP_HUMANNFKB2_HUMANIntAct14743216 details
SYEP_HUMANM3K14_HUMANIntAct14743216 details
SYEP_HUMANTF65_HUMANIntAct14743216 details
SYEP_HUMANRELB_HUMANIntAct14743216 details
SYEP_HUMANRIPK3_HUMANIntAct14743216 details
SYEP_HUMANM3K7_HUMANIntAct14743216 details
SYEP_HUMANATG12_HUMANIntAct17353931 details
SYEP_HUMAN1433Z_HUMANMINT15161933 details
SYEP_HUMANETS1_HUMANIntAct20195357 details
SYEP_HUMANMLP3A_HUMANBioGRID, IntAct20562859 22963397 details
SYEP_HUMANHNRPQ_HUMANDIP, HPRD, IntAct15479637 21220307 22386318 details
SYEP_HUMANSYK_HUMANBioGRID, DIP, IntAct21220307 22386318 22751010 22939629 26344197 28514442 31536960 details
SYEP_HUMANAIMP2_HUMANBioGRID, DIP, HPRD18695251 22939629 26344197 31792442 9878398 details
SYEP_HUMANHDAC5_HUMANBioGRID21081666 details
SYEP_HUMANITA4_HUMANBioGRID22623428 details
SYEP_HUMANEGFR_HUMANBioGRID23956138 details
SYEP_HUMANRN126_HUMANBioGRID26508657 details
SYEP_HUMANU2AF2_HUMANBioGRID26641092 details
SYEP_HUMANCA131_HUMANBioGRID26472760 details
SYEP_HUMANMYO6_HUMANBioGRID26950368 details
SYEP_HUMANISG15_HUMANBioGRID33024031 details
SYEP_HUMANDUS2L_HUMANHPRD15994936 details