Entity Details

Primary name IGF1R_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP08069
EntryNameIGF1R_HUMAN
FullNameInsulin-like growth factor 1 receptor
TaxID9606
Evidenceevidence at protein level
Length1367
SequenceStatuscomplete
DateCreated1988-08-01
DateModified2021-06-02

Ontological Relatives

GenesIGF1R

GO terms

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GOName
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005009 insulin-activated receptor activity
GO:0005010 insulin-like growth factor-activated receptor activity
GO:0005158 insulin receptor binding
GO:0005198 structural molecule activity
GO:0005520 insulin-like growth factor binding
GO:0005524 ATP binding
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005899 insulin receptor complex
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0008284 positive regulation of cell population proliferation
GO:0008286 insulin receptor signaling pathway
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016020 membrane
GO:0016032 viral process
GO:0030335 positive regulation of cell migration
GO:0030424 axon
GO:0031994 insulin-like growth factor I binding
GO:0033674 positive regulation of kinase activity
GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex
GO:0038083 peptidyl-tyrosine autophosphorylation
GO:0042593 glucose homeostasis
GO:0042802 identical protein binding
GO:0043066 negative regulation of apoptotic process
GO:0043231 intracellular membrane-bounded organelle
GO:0043235 receptor complex
GO:0043243 positive regulation of protein-containing complex disassembly
GO:0043410 positive regulation of MAPK cascade
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0043559 insulin binding
GO:0043560 insulin receptor substrate binding
GO:0045056 transcytosis
GO:0046328 regulation of JNK cascade
GO:0046777 protein autophosphorylation
GO:0048009 insulin-like growth factor receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0051389 obsolete inactivation of MAPKK activity
GO:0051897 positive regulation of protein kinase B signaling
GO:0071333 cellular response to glucose stimulus
GO:0097062 dendritic spine maintenance
GO:0097242 amyloid-beta clearance
GO:0120162 positive regulation of cold-induced thermogenesis
GO:0140318 protein transporter activity
GO:1902911 protein kinase complex
GO:1904646 cellular response to amyloid-beta

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000494 Receptor L-domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR002011 Tyrosine-protein kinase, receptor class II, conserved siteSiteConserved site
IPR003961 Fibronectin type IIIDomainDomain
IPR006211 Furin-like cysteine-rich domainDomainDomain
IPR006212 Furin-like repeatRepeatRepeat
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR016246 Tyrosine-protein kinase, insulin-like receptorFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily
IPR036941 Receptor L-domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
270450 OMIMInsulin-like growth factor 1 resistance (IGF1RES)A disorder characterized by intrauterine growth retardation, poor postnatal growth and increased plasma IGF1 levels. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00030 Insulin humanDrugbankbiotech
DB00046 Insulin lisproDrugbankbiotech
DB00047 Insulin glargineDrugbankbiotech
DB00071 Insulin porkDrugbankbiotech
DB01277 MecaserminDrugbankbiotech
DB01306 Insulin aspartDrugbankbiotech
DB01307 Insulin detemirDrugbankbiotech
DB01309 Insulin glulisineDrugbankbiotech
DB04395 Phosphoaminophosphonic Acid-Adenylate EsterDrugbanksmall molecule
DB05023 ATL1101Drugbanksmall molecule
DB05184 XL228Drugbanksmall molecule
DB05897 rhIGFBP-3Drugbanksmall molecule
DB06075 LinsitinibDrugbanksmall molecule
DB06343 TeprotumumabDrugbankbiotech
DB07156 (4Z)-6-bromo-4-({[4-(pyrrolidin-1-ylmethyl)phenyl]amino}methylidene)isoquinoline-1,3(2H,4H)-dioneDrugbanksmall molecule
DB07474 3-[5-(1H-IMIDAZOL-1-YL)-7-METHYL-1H-BENZIMIDAZOL-2-YL]-4-[(PYRIDIN-2-YLMETHYL)AMINO]PYRIDIN-2(1H)-ONEDrugbanksmall molecule
DB09098 SomatremDrugbankbiotech
DB09564 Insulin degludecDrugbankbiotech
DB12250 CixutumumabDrugbankbiotech
DB12267 BrigatinibDrugbanksmall molecule
DB14751 Mecasermin rinfabateDrugbankbiotech

Interactions

123 interactions

InteractorPartnerSourcesPublicationsLink
IGF1R_HUMAN1433B_HUMANBioGRID, HPRD, IntAct, MINT14651979 15629149 17353931 9581554 details
IGF1R_HUMANCSK_HUMANBioGRID, HPRD, MINT10026153 details
IGF1R_HUMANGRB10_HUMANBioGRID, HPRD, MINT12697834 19165858 8621530 8764099 8776723 9369444 9506989 details
IGF1R_HUMANIRS2_HUMANHPRD, MINT8662806 9852124 details
IGF1R_HUMAN1433E_HUMANBioGRID, HPRD, MINT27684187 9111084 details
IGF1R_HUMANCRK_HUMANHPRD, IntAct11956190 12198159 15522217 8875975 9480911 9642287 details
IGF1R_HUMANSHC1_HUMANBioGRID, IntAct14764897 15629149 16113100 24051437 7541045 7559507 8776723 details
IGF1R_HUMANARHGC_HUMANBioGRID, HPRD, MINT11724822 details
IGF1R_HUMANIGF1R_HUMANDIP, HPRD, IntAct, MINT11448933 11591350 12138114 17586502 21645859 details
IGF1R_HUMANPTN1_HUMANBioGRID, HPRD, MINT15976035 16926280 8999839 details
IGF1R_HUMANP85B_HUMANHPRD, IntAct7541045 details
IGF1R_HUMANIRS1_HUMANBioGRID, HPRD, IntAct10082579 12220227 15629149 7541045 7559507 8530377 8662806 8776723 8895367 details
IGF1R_HUMANMDM2_HUMANBioGRID, HPRD, IntAct12821780 18632619 19165858 20195357 25241761 28092675 details
IGF1R_HUMANP85A_HUMANBioGRID, HPRD, IntAct, MINT25241761 7589433 7642582 8603569 8697095 details
IGF1R_HUMANPTN11_HUMANBioGRID, HPRD, MINT10082579 28065597 7642582 8895367 details
IGF1R_HUMANRASA1_HUMANBioGRID, HPRD, MINT7642582 details
IGF1R_HUMANAMYP_HUMANBioGRID, IntAct21988832 details
IGF1R_HUMANFFAR2_HUMANBioGRID, IntAct21988832 details
IGF1R_HUMANGRB14_HUMANBioGRID, IntAct21988832 details
IGF1R_HUMANRL11_HUMANBioGRID, IntAct21988832 27684187 details
IGF1R_HUMANCRKL_HUMANBioGRID, HPRD, IntAct15522217 25241761 details
IGF1R_HUMANP55G_HUMANBioGRID, DIP, HPRD, IntAct17360667 25241761 9415396 9524259 details
IGF1R_HUMANCP17A_HUMANBioGRID, MINT25640309 details
IGF1R_HUMANHXC6_HUMANBioGRID, MINT25640309 details
IGF1R_HUMANI13R2_HUMANBioGRID, MINT25640309 details
IGF1R_HUMANLYPD3_HUMANBioGRID, MINT25640309 details
IGF1R_HUMANKLK5_HUMANBioGRID, MINT25640309 details
IGF1R_HUMANMTA3_HUMANBioGRID, MINT25640309 details
IGF1R_HUMANARY2_HUMANBioGRID, MINT25640309 details
IGF1R_HUMANTHRSP_HUMANBioGRID, MINT25640309 details
IGF1R_HUMANBAP1_HUMANBioGRID, MINT25640309 details
IGF1R_HUMANTRI25_HUMANBioGRID, MINT25640309 29117863 details
IGF1R_HUMANVPS45_HUMANBioGRID, MINT25640309 details
IGF1R_HUMANIGF1_HUMANbhf-ucl, BioGRID, DIP, HPRD1852007 21645859 26027733 8452530 details
IGF1R_HUMANCSEN_HUMANBioGRID, IntAct25416956 32296183 details
IGF1R_HUMANPTN6_HUMANBioGRID, MINT28065597 details
IGF1R_HUMANPPM1A_HUMANBioGRID, MINT28065597 details
IGF1R_HUMANSTYX_HUMANBioGRID, MINT28065597 details
IGF1R_HUMANDUS14_HUMANBioGRID, MINT28065597 details
IGF1R_HUMANDUS10_HUMANBioGRID, MINT28065597 details
IGF1R_HUMANILKAP_HUMANBioGRID, MINT28065597 details
IGF1R_HUMANDUS29_HUMANBioGRID, MINT28065597 details
IGF1R_HUMANDUS26_HUMANBioGRID, MINT28065597 details
IGF1R_HUMANDUS21_HUMANBioGRID, MINT28065597 details
IGF1R_HUMANDUS19_HUMANBioGRID, MINT28065597 details
IGF1R_HUMANDUS18_HUMANBioGRID, MINT28065597 details
IGF1R_HUMANDUS15_HUMANBioGRID, MINT28065597 details
IGF1R_HUMANPTPRR_HUMANBioGRID, MINT28065597 details
IGF1R_HUMANPTN7_HUMANBioGRID, MINT28065597 details
IGF1R_HUMANPTN12_HUMANBioGRID, MINT28065597 details
IGF1R_HUMANSOCS1_HUMANBioGRID, HPRD29991678 9727029 details
IGF1R_HUMANNEDD4_HUMANBioGRID, HPRD12697834 18632619 19165858 details
IGF1R_HUMANEHD1_HUMANBioGRID, HPRD11423532 details
IGF1R_HUMANJAK1_HUMANBioGRID, HPRD9492017 details
IGF1R_HUMANSOCS2_HUMANBioGRID, HPRD29559623 9727029 details
IGF1R_HUMANSOCS3_HUMANBioGRID, HPRD11071852 details
IGF1R_HUMANRACK1_HUMANBioGRID, HPRD11884618 11964397 16382134 20871634 27684187 details
IGF1R_HUMANCBL_HUMANBioGRID, HPRD18632619 details
IGF1R_HUMANERBB2_HUMANBioGRID17307140 30898150 details
IGF1R_HUMANCAMP_HUMANBioGRID21685939 details
IGF1R_HUMANA4_HUMANBioGRID21832049 details
IGF1R_HUMANSH2B1_HUMANBioGRID15767667 details
IGF1R_HUMANPCNA_HUMANBioGRID27684187 28924044 32701997 details
IGF1R_HUMANSHPS1_HUMANBioGRID21799000 details
IGF1R_HUMANERD22_HUMANBioGRID28205554 details
IGF1R_HUMANGRM1_HUMANBioGRID28205554 details
IGF1R_HUMANCDK4_HUMANBioGRID28205554 details
IGF1R_HUMANCDN2B_HUMANBioGRID28205554 details
IGF1R_HUMANFGFR4_HUMANBioGRID28205554 details
IGF1R_HUMANMERL_HUMANBioGRID28205554 details
IGF1R_HUMANTF65_HUMANBioGRID28205554 details
IGF1R_HUMANTTYH2_HUMANBioGRID28205554 details
IGF1R_HUMANGIPC1_HUMANHPRD11445579 details
IGF1R_HUMAN1433Z_HUMANBioGRID, HPRD, MINT27684187 9581554 details
IGF1R_HUMANCADH3_HUMANI2D21317933 details
IGF1R_HUMANTAGL_HUMANMINT22245152 details
IGF1R_HUMANLEF1_HUMANMINT22261717 details
IGF1R_HUMANCTNB1_HUMANBioGRID, MINT22261717 27684187 details
IGF1R_HUMANARRB1_HUMANBioGRID, I2D15878855 21685939 details
IGF1R_HUMANHS90B_HUMANBioGRID, IntAct22939624 27684187 details
IGF1R_HUMANSTAT3_HUMANBioGRID, HPRD, IntAct11463827 25241761 29559623 details
IGF1R_HUMANITB1_HUMANIntAct15289498 details
IGF1R_HUMANSNP29_HUMANBioGRID11423532 details
IGF1R_HUMANIBP3_HUMANBioGRID, HPRD9389554 details
IGF1R_HUMANESR1_HUMANBioGRID, HPRD10749889 14764897 16113100 24051437 28555617 details
IGF1R_HUMANEGFR_HUMANBioGRID17047074 17307140 details
IGF1R_HUMANFAK1_HUMANBioGRID10082579 details
IGF1R_HUMANPAXI_HUMANBioGRID10082579 details
IGF1R_HUMANVAV3_HUMANBioGRID, HPRD11094073 details
IGF1R_HUMANGNAI1_HUMANBioGRID, HPRD10644671 details
IGF1R_HUMANEEA1_HUMANBioGRID, HPRD18632619 details
IGF1R_HUMANARRB2_HUMANBioGRID15878855 19165858 23188799 details
IGF1R_HUMANP53_HUMANBioGRID19165858 details
IGF1R_HUMANPHB2_HUMANBioGRID24051437 28555617 details
IGF1R_HUMANSYVN1_HUMANBioGRID26536657 details
IGF1R_HUMANPPM1F_HUMANBioGRID28065597 details
IGF1R_HUMANMPZL2_HUMANBioGRID28065597 details
IGF1R_HUMANSSH1_HUMANBioGRID28065597 details
IGF1R_HUMANUBQL1_HUMANBioGRID28075048 29054976 details
IGF1R_HUMANINSR_HUMANBioGRID, HPRD27684187 7895674 details
IGF1R_HUMANAPBB1_HUMANBioGRID27836546 details
IGF1R_HUMANAKT1_HUMANBioGRID29523594 details
IGF1R_HUMANHDAC3_HUMANBioGRID29523594 details
IGF1R_HUMANDP13A_HUMANBioGRID29523594 details
IGF1R_HUMANSRC_HUMANBioGRID, HPRD11964397 8940173 details
IGF1R_HUMANMATK_HUMANBioGRID21799000 details
IGF1R_HUMANGHR_HUMANBioGRID15044591 details
IGF1R_HUMANJAK2_HUMANBioGRID, HPRD10747872 15044591 9492017 details
IGF1R_HUMANBIG3_HUMANBioGRID28555617 details
IGF1R_HUMANUSP9X_HUMANBioGRID30338032 details
IGF1R_HUMANKPCD_HUMANHPRD11884618 details
IGF1R_HUMANKPCD1_HUMANHPRD11884618 details
IGF1R_HUMANM3K5_HUMANHPRD12556535 details
IGF1R_HUMANIRS4_HUMANHPRD11316748 9553137 details
IGF1R_HUMANDOK4_HUMANHPRD12730241 details
IGF1R_HUMANKLOT_HUMANHPRD18762812 details
IGF1R_HUMANUBC_HUMANHPRD18632619 details
IGF1R_HUMANCAV1_HUMANHPRD18632619 details
IGF1R_HUMANGNAI2_HUMANHPRD11120746 details
IGF1R_HUMANIGF2_HUMANHPRD9972281 details
IGF1R_HUMANINS_HUMANHPRD1851182 details
IGF1R_HUMANDOK5_HUMANHPRD12730241 details
IGF1R_HUMANK1C27_HUMANHPRD15629149 details