Entity Details

Primary name GLI1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP08151
EntryNameGLI1_HUMAN
FullNameZinc finger protein GLI1
TaxID9606
Evidenceevidence at protein level
Length1106
SequenceStatuscomplete
DateCreated1988-08-01
DateModified2021-06-02

Ontological Relatives

GenesGLI1

GO terms

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GOName
GO:0000976 transcription cis-regulatory region binding
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001649 osteoblast differentiation
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005930 axoneme
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007224 smoothened signaling pathway
GO:0007283 spermatogenesis
GO:0007418 ventral midline development
GO:0008017 microtubule binding
GO:0008284 positive regulation of cell population proliferation
GO:0008589 regulation of smoothened signaling pathway
GO:0009611 response to wounding
GO:0009913 epidermal cell differentiation
GO:0009953 dorsal/ventral pattern formation
GO:0009954 proximal/distal pattern formation
GO:0021696 cerebellar cortex morphogenesis
GO:0021938 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
GO:0021983 pituitary gland development
GO:0030324 lung development
GO:0030335 positive regulation of cell migration
GO:0030850 prostate gland development
GO:0043565 sequence-specific DNA binding
GO:0045667 regulation of osteoblast differentiation
GO:0045740 positive regulation of DNA replication
GO:0045880 positive regulation of smoothened signaling pathway
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046872 metal ion binding
GO:0048546 digestive tract morphogenesis
GO:0060032 notochord regression
GO:0060045 positive regulation of cardiac muscle cell proliferation
GO:0060070 canonical Wnt signaling pathway
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0097421 liver regeneration
GO:0097542 ciliary tip
GO:0097546 ciliary base
GO:1902808 positive regulation of cell cycle G1/S phase transition
GO:2000345 regulation of hepatocyte proliferation

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR013087 Zinc finger C2H2-typeDomainDomain
IPR032850 Zinc finger protein GLI1FamilyFamily
IPR036236 Zinc finger C2H2 superfamilyFamilyHomologous superfamily
IPR043359 C2H2-type zinc-finger protein GLI-likeFamilyFamily

Diseases

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Disease IDSourceNameDescription
618123 OMIMPolydactyly, postaxial, A8 (PAPA8)A form of postaxial polydactyly, a condition characterized by the occurrence of supernumerary digits in the upper and/or lower extremities. In postaxial polydactyly type A, the extra digit is well-formed and articulates with the fifth or a sixth metacarpal/metatarsal. PAPA8 is an autosomal recessive condition characterized by the presence of postaxial extra digits (hexadactyly) on the hands and/or the feet. The disease is caused by variants affecting the gene represented in this entry.
174400 OMIMPolydactyly, preaxial 1 (PPD1)A form of polydactyly, a condition defined by the occurrence of supernumerary digits in the upper and/or lower extremities. Preaxial or radial polydactyly refers to the presence of extra digits on the radial side of the hand. PPD1 is an autosomal recessive form characterized by duplication of the distal phalanx of the thumb. The disease may be caused by variants affecting the gene represented in this entry.

Interactions

73 interactions

InteractorPartnerSourcesPublicationsLink
GLI1_HUMANSUFU_HUMANBioGRID, HPRD, IntAct, MINT10559945 10564661 12426310 20211142 21543335 22439934 24217340 24311597 24854174 25241761 25609649 27234298 29249966 29662197 31278361 32296183 details
GLI1_HUMANITCH_HUMANBioGRID, I2D20818436 31278361 details
GLI1_HUMANCDK4_HUMANBioGRID, IntAct22094256 26603838 details
GLI1_HUMANKS6B1_HUMANIntAct22439934 details
GLI1_HUMANTRI42_HUMANBioGRID, IntAct25416956 details
GLI1_HUMANAAPK2_HUMANBioGRID, IntAct25416956 details
GLI1_HUMANGCC1_HUMANBioGRID, IntAct25416956 details
GLI1_HUMANCTSR1_HUMANBioGRID, IntAct32296183 details
GLI1_HUMANPIN1_HUMANBioGRID, IntAct28167297 32296183 details
GLI1_HUMANAQP1_HUMANBioGRID, IntAct32296183 details
GLI1_HUMANCRBA4_HUMANBioGRID, IntAct25910212 details
GLI1_HUMANKPCI_HUMANBioGRID, DIP23446420 30389910 details
GLI1_HUMANRAI1_HUMANBioGRID, IntAct20211142 details
GLI1_HUMANXBP1_HUMANBioGRID, IntAct20211142 details
GLI1_HUMANZIC1_HUMANBioGRID, HPRD11238441 details
GLI1_HUMANNUMB_HUMANBioGRID20818436 details
GLI1_HUMANFEM1B_HUMANBioGRID24076122 details
GLI1_HUMANIKKB_HUMANBioGRID26603838 details
GLI1_HUMANKAPCA_HUMANBioGRID16293631 details
GLI1_HUMANUBP48_HUMANBioGRID28623188 details
GLI1_HUMANTAF9_HUMANBioGRID26282181 details
GLI1_HUMANMEP50_HUMANBioGRID30675521 details
GLI1_HUMANANM5_HUMANBioGRID30675521 details
GLI1_HUMANANM1_HUMANBioGRID26762411 details
GLI1_HUMANM3K2_HUMANBioGRID29662197 details
GLI1_HUMANM3K3_HUMANBioGRID29662197 details
GLI1_HUMANTCPB_HUMANBioGRID31462707 details
GLI1_HUMANRUNX3_HUMANBioGRID31278361 details
GLI1_HUMANSTK36_HUMANBioGRID, HPRD, IntAct10806483 25241761 details
GLI1_HUMAN1433E_HUMANMINT19996099 details
GLI1_HUMANVHL_HUMANBioGRID, MINT23395608 details
GLI1_HUMANZIC2_HUMANBioGRID, HPRD11238441 details
GLI1_HUMANSAP18_HUMANBioGRID11960000 details
GLI1_HUMANHDAC1_HUMANBioGRID20081843 31558698 details
GLI1_HUMANHDAC2_HUMANBioGRID20081843 details
GLI1_HUMANSMAD4_HUMANBioGRID24739390 details
GLI1_HUMANSMAD2_HUMANBioGRID24739390 details
GLI1_HUMANKAT2B_HUMANBioGRID23943798 24739390 31278361 details
GLI1_HUMANFBW1A_HUMANBioGRID25632159 28562331 31278361 details
GLI1_HUMANTHOC4_HUMANBioGRID25609649 26603838 details
GLI1_HUMANUBP7_HUMANBioGRID26120032 details
GLI1_HUMANPHB2_HUMANBioGRID26603838 details
GLI1_HUMANEF1D_HUMANBioGRID26603838 details
GLI1_HUMANNPM_HUMANBioGRID26603838 details
GLI1_HUMANEIF3I_HUMANBioGRID26603838 details
GLI1_HUMANCAPZB_HUMANBioGRID26603838 details
GLI1_HUMANCAZA2_HUMANBioGRID26603838 details
GLI1_HUMANARPC2_HUMANBioGRID26603838 details
GLI1_HUMANCDK1_HUMANBioGRID26603838 details
GLI1_HUMANBUB3_HUMANBioGRID26603838 details
GLI1_HUMANRACK1_HUMANBioGRID26603838 details
GLI1_HUMANPGAM5_HUMANBioGRID26603838 details
GLI1_HUMANGNAI1_HUMANBioGRID26603838 details
GLI1_HUMANGNA13_HUMANBioGRID26603838 details
GLI1_HUMANPP1B_HUMANBioGRID26603838 details
GLI1_HUMANGBB1_HUMANBioGRID26603838 details
GLI1_HUMANIKKA_HUMANBioGRID26603838 details
GLI1_HUMANFXL17_HUMANBioGRID27234298 details
GLI1_HUMANUBP21_HUMANBioGRID27621083 details
GLI1_HUMANAAPK1_HUMANBioGRID28562331 details
GLI1_HUMANUBP37_HUMANBioGRID30482232 details
GLI1_HUMANIPO7_HUMANBioGRID26085085 details
GLI1_HUMANSTAT3_HUMANBioGRID29449694 details
GLI1_HUMANRRAS2_HUMANBioGRID29449694 details
GLI1_HUMANCEP70_HUMANBioGRID29449694 details
GLI1_HUMANREN3A_HUMANBioGRID29449694 details
GLI1_HUMANASPP2_HUMANBioGRID30389910 details
GLI1_HUMANZN521_HUMANBioGRID31558698 details
GLI1_HUMANYAP1_HUMANBioGRID31957872 details
GLI1_HUMANIMB1_HUMANBioGRID24854174 details
GLI1_HUMANAKT1_HUMANBioGRID23580656 details
GLI1_HUMANRL30_HUMANBioGRID23580656 details
GLI1_HUMANDYR1A_HUMANHPRD12138125 details