Entity Details

Primary name TGFB3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP10600
EntryNameTGFB3_HUMAN
FullNameTransforming growth factor beta-3 proprotein
TaxID9606
Evidenceevidence at protein level
Length412
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesTGFB3

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0001666 response to hypoxia
GO:0001701 in utero embryonic development
GO:0002576 platelet degranulation
GO:0005114 type II transforming growth factor beta receptor binding
GO:0005125 cytokine activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007435 salivary gland morphogenesis
GO:0007565 female pregnancy
GO:0007568 aging
GO:0008083 growth factor activity
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0009986 cell surface
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0010936 negative regulation of macrophage cytokine production
GO:0030315 T-tubule
GO:0030501 positive regulation of bone mineralization
GO:0030509 BMP signaling pathway
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030879 mammary gland development
GO:0031093 platelet alpha granule lumen
GO:0032570 response to progesterone
GO:0032967 positive regulation of collagen biosynthetic process
GO:0034616 response to laminar fluid shear stress
GO:0034713 type I transforming growth factor beta receptor binding
GO:0034714 type III transforming growth factor beta receptor binding
GO:0042060 wound healing
GO:0042127 regulation of cell population proliferation
GO:0042476 odontogenesis
GO:0042704 uterine wall breakdown
GO:0042802 identical protein binding
GO:0043025 neuronal cell body
GO:0043065 positive regulation of apoptotic process
GO:0043231 intracellular membrane-bounded organelle
GO:0043524 negative regulation of neuron apoptotic process
GO:0043627 response to estrogen
GO:0043932 ossification involved in bone remodeling
GO:0044877 protein-containing complex binding
GO:0045216 cell-cell junction organization
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048286 lung alveolus development
GO:0048565 digestive tract development
GO:0048702 embryonic neurocranium morphogenesis
GO:0048839 inner ear development
GO:0050431 transforming growth factor beta binding
GO:0050714 positive regulation of protein secretion
GO:0051491 positive regulation of filopodium assembly
GO:0051496 positive regulation of stress fiber assembly
GO:0051781 positive regulation of cell division
GO:0060325 face morphogenesis
GO:0060364 frontal suture morphogenesis
GO:0060391 positive regulation of SMAD protein signal transduction
GO:0060395 SMAD protein signal transduction
GO:0062009 secondary palate development
GO:0062023 collagen-containing extracellular matrix
GO:0070483 detection of hypoxia
GO:1904706 negative regulation of vascular associated smooth muscle cell proliferation
GO:1905075 positive regulation of tight junction disassembly

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR001111 TGF-beta, propeptideDomainDomain
IPR001839 Transforming growth factor-beta, C-terminalDomainDomain
IPR015615 Transforming growth factor-beta-relatedFamilyFamily
IPR015618 Transforming growth factor beta-3FamilyFamily
IPR016319 Transforming growth factor-betaFamilyFamily
IPR017948 Transforming growth factor beta, conserved siteSiteConserved site
IPR029034 Cystine-knot cytokineFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB03316 1,4-DioxaneDrugbanksmall molecule