Entity Details

Primary name DMD_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP11532
EntryNameDMD_HUMAN
FullNameDystrophin
TaxID9606
Evidenceevidence at protein level
Length3685
SequenceStatuscomplete
DateCreated1989-10-01
DateModified2021-06-02

Ontological Relatives

GenesDMD

GO terms

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GOName
GO:0002027 regulation of heart rate
GO:0002162 dystroglycan binding
GO:0003779 actin binding
GO:0005200 structural constituent of cytoskeleton
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0007517 muscle organ development
GO:0008270 zinc ion binding
GO:0008307 structural constituent of muscle
GO:0009986 cell surface
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0010976 positive regulation of neuron projection development
GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
GO:0014819 regulation of skeletal muscle contraction
GO:0016010 dystrophin-associated glycoprotein complex
GO:0016013 syntrophin complex
GO:0017022 myosin binding
GO:0017166 vinculin binding
GO:0030018 Z disc
GO:0030049 muscle filament sliding
GO:0030055 cell-substrate junction
GO:0030175 filopodium
GO:0031527 filopodium membrane
GO:0032991 protein-containing complex
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0034613 cellular protein localization
GO:0034622 cellular protein-containing complex assembly
GO:0035633 maintenance of blood-brain barrier
GO:0035994 response to muscle stretch
GO:0042383 sarcolemma
GO:0043034 costamere
GO:0043043 peptide biosynthetic process
GO:0044306 neuron projection terminus
GO:0044458 motile cilium assembly
GO:0045121 membrane raft
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0045666 positive regulation of neuron differentiation
GO:0046716 muscle cell cellular homeostasis
GO:0050998 nitric-oxide synthase binding
GO:0060048 cardiac muscle contraction
GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity
GO:0086001 cardiac muscle cell action potential
GO:0090287 regulation of cellular response to growth factor stimulus
GO:1901385 regulation of voltage-gated calcium channel activity
GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation
GO:2000651 positive regulation of sodium ion transmembrane transporter activity

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR000433 Zinc finger, ZZ-typeDomainDomain
IPR001202 WW domainDomainDomain
IPR001589 Actinin-type actin-binding domain, conserved siteSiteConserved site
IPR001715 Calponin homology domainDomainDomain
IPR002017 Spectrin repeatRepeatRepeat
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR015153 EF-hand domain, type 1DomainDomain
IPR015154 EF-hand domain, type 2DomainDomain
IPR018159 Spectrin/alpha-actininRepeatRepeat
IPR035436 Dystrophin/utrophinFamilyFamily
IPR036020 WW domain superfamilyFamilyHomologous superfamily
IPR036872 CH domain superfamilyFamilyHomologous superfamily
IPR043145 Zinc finger, ZZ-type superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB15593 GolodirsenDrugbankbiotech

Interactions

42 interactions

InteractorPartnerSourcesPublicationsLink
DMD_HUMANDTNA_HUMANBioGRID, HPRD, IntAct, MINT10767429 16448387 28514442 9356463 9701558 details
DMD_HUMANDTNB_HUMANBioGRID, HPRD, IntAct, MINT10545507 16448387 25416956 28514442 31515488 32296183 9395493 details
DMD_HUMANSNTB1_HUMANBioGRID, HPRD, IntAct28514442 7844150 8576247 details
DMD_HUMANSNTB2_HUMANBioGRID, HPRD, IntAct22937058 28514442 8576247 details
DMD_HUMANDISC1_HUMANBioGRID, IntAct17043677 31413325 details
DMD_HUMANDAG1_HUMANBioGRID, HPRD, IntAct10355629 10932245 19109891 7592992 details
DMD_HUMANM3K5_HUMANBioGRID, IntAct20936779 details
DMD_HUMANMPIP1_HUMANBioGRID, IntAct21988832 details
DMD_HUMANHAUS1_HUMANBioGRID, IntAct25416956 28514442 details
DMD_HUMANCTNL1_HUMANBioGRID, IntAct21115837 25416956 28514442 32296183 details
DMD_HUMANPICK1_HUMANBioGRID, IntAct32296183 details
DMD_HUMANHNF4A_HUMANBioGRID, IntAct25910212 details
DMD_HUMANSNTA1_HUMANBioGRID, HPRD, IntAct10747910 11571312 18468998 28514442 7890602 8576247 9412493 details
DMD_HUMANSNTG2_HUMANBioGRID, HPRD, IntAct10747910 28514442 details
DMD_HUMANMIPT3_HUMANBioGRID, IntAct17043677 31413325 details
DMD_HUMANACTS_HUMANBioGRID, HPRD11259305 1544421 details
DMD_HUMANA4_HUMANBioGRID21832049 details
DMD_HUMANSNTG1_HUMANBioGRID, HPRD10747910 11352924 details
DMD_HUMANTRI63_HUMANBioGRID33106653 details
DMD_HUMANCAPS1_HUMANHPRD12659812 details
DMD_HUMANCAPS2_HUMANHPRD12659812 details
DMD_HUMANK1C19_HUMANHPRD, IntAct16000376 details
DMD_HUMANANK2_HUMANIntAct19109891 details
DMD_HUMANUTRN_HUMANBioGRID, HPRD, IntAct10767429 28514442 details
DMD_HUMANKCJ12_HUMANBioGRID, HPRD15024025 details
DMD_HUMANKCNJ4_HUMANBioGRID15024025 details
DMD_HUMANTERF1_HUMANBioGRID20811636 details
DMD_HUMANTERF2_HUMANBioGRID20811636 details
DMD_HUMANNFX1_HUMANBioGRID17267499 details
DMD_HUMANMARK2_HUMANBioGRID19945424 details
DMD_HUMANCAVN1_HUMANBioGRID22937058 details
DMD_HUMANAHNK_HUMANBioGRID22937058 details
DMD_HUMANNOS1_HUMANBioGRID7545544 details
DMD_HUMANGAN_HUMANBioGRID26460568 details
DMD_HUMANAPRIO_HUMANBioGRID11032878 details
DMD_HUMANPRIO_HUMANBioGRID11032878 details
DMD_HUMANPGM5_HUMANHPRD10867799 7890770 details
DMD_HUMANDGKZ_HUMANHPRD11352924 details
DMD_HUMANSGCZ_HUMANHPRD12189167 details
DMD_HUMANDMD_HUMANHPRD10801490 details
DMD_HUMANACTC_HUMANHPRD11997265 details
DMD_HUMANTNFL6_HUMANHPRD11741599 details