Entity Details

Primary name HEM2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP13716
EntryNameHEM2_HUMAN
FullNameDelta-aminolevulinic acid dehydratase
TaxID9606
Evidenceevidence at protein level
Length330
SequenceStatuscomplete
DateCreated1990-01-01
DateModified2021-06-02

Ontological Relatives

GenesALAD

GO terms

Show/Hide Table
GOName
GO:0001666 response to hypoxia
GO:0003824 catalytic activity
GO:0004655 porphobilinogen synthase activity
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005829 cytosol
GO:0006782 protoporphyrinogen IX biosynthetic process
GO:0006783 heme biosynthetic process
GO:0006979 response to oxidative stress
GO:0008270 zinc ion binding
GO:0009635 response to herbicide
GO:0010039 response to iron ion
GO:0010043 response to zinc ion
GO:0010044 response to aluminum ion
GO:0010212 response to ionizing radiation
GO:0010266 response to vitamin B1
GO:0010269 response to selenium ion
GO:0014823 response to activity
GO:0032025 response to cobalt ion
GO:0032496 response to lipopolysaccharide
GO:0033197 response to vitamin E
GO:0034774 secretory granule lumen
GO:0042493 response to drug
GO:0042802 identical protein binding
GO:0043200 response to amino acid
GO:0043312 neutrophil degranulation
GO:0045471 response to ethanol
GO:0046685 response to arsenic-containing substance
GO:0046686 response to cadmium ion
GO:0046689 response to mercury ion
GO:0051260 protein homooligomerization
GO:0051384 response to glucocorticoid
GO:0051597 response to methylmercury
GO:0070062 extracellular exosome
GO:0070541 response to platinum ion
GO:0070542 response to fatty acid
GO:0071284 cellular response to lead ion
GO:0071353 cellular response to interleukin-4
GO:1901799 negative regulation of proteasomal protein catabolic process
GO:1904813 ficolin-1-rich granule lumen
GO:1904854 proteasome core complex binding

Subcellular Location

Show/Hide Table

Domains

Show/Hide Table
DomainNameCategoryType
IPR001731 Delta-aminolevulinic acid dehydrataseFamilyFamily
IPR013785 Aldolase-type TIM barrelFamilyHomologous superfamily
IPR030656 Delta-aminolevulinic acid dehydratase, active siteSiteActive site

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB00855 Aminolevulinic acidDrugbanksmall molecule
DB02068 Delta-Amino Valeric AcidDrugbanksmall molecule
DB02239 Laevulinic AcidDrugbanksmall molecule
DB02260 4-Oxosebacic AcidDrugbanksmall molecule
DB02272 PorphobilinogenDrugbanksmall molecule
DB02878 3-(2-Aminoethyl)-4-(Aminomethyl)Heptanedioic AcidDrugbanksmall molecule
DB04560 4,7-Dioxosebacic AcidDrugbanksmall molecule
DB04781 5-hydroxyvaleric acidDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
HEM2_HUMANHEM2_HUMANHPRD11591653 details