Entity Details

Primary name DRB4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP13762
EntryNameDRB4_HUMAN
FullNameHLA class II histocompatibility antigen, DR beta 4 chain
TaxID9606
Evidenceevidence at protein level
Length266
SequenceStatuscomplete
DateCreated1990-01-01
DateModified2021-04-07

Ontological Relatives

GenesHLA-DRB4

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0002250 adaptive immune response
GO:0005765 lysosomal membrane
GO:0005886 plasma membrane
GO:0012507 ER to Golgi transport vesicle membrane
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0030658 transport vesicle membrane
GO:0030666 endocytic vesicle membrane
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0031902 late endosome membrane
GO:0032588 trans-Golgi network membrane
GO:0042613 MHC class II protein complex
GO:0050852 T cell receptor signaling pathway
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane

Subcellular Location

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Subcellular Location
Cell membrane
Endoplasmic reticulum membrane
Endosome membrane
Golgi apparatus
Late endosome membrane
Lysosome membrane

Domains

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DomainNameCategoryType
IPR000353 MHC class II, beta chain, N-terminalDomainDomain
IPR003006 Immunoglobulin/major histocompatibility complex, conserved siteSiteConserved site
IPR003597 Immunoglobulin C1-setDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR011162 MHC classes I/II-like antigen recognition proteinFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR014745 MHC class II, alpha/beta chain, N-terminalFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB05121 1D09C3Drugbankbiotech
DB11294 Coccidioides immitis spheruleDrugbankbiotech

Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
DRB4_HUMANASML_HUMANBioGRID, IntAct21988832 details
DRB4_HUMANMAGA6_HUMANBioGRID12631591 details
DRB4_HUMANCTG1B_HUMANHPRD11782380 details