Entity Details

Primary name MIF_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP14174
EntryNameMIF_HUMAN
FullNameMacrophage migration inhibitory factor
TaxID9606
Evidenceevidence at protein level
Length115
SequenceStatuscomplete
DateCreated1990-01-01
DateModified2021-06-02

Ontological Relatives

GenesMIF

GO terms

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GOName
GO:0001516 prostaglandin biosynthetic process
GO:0001819 positive regulation of cytokine production
GO:0004167 dopachrome isomerase activity
GO:0005125 cytokine activity
GO:0005126 cytokine receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006954 inflammatory response
GO:0007166 cell surface receptor signaling pathway
GO:0009986 cell surface
GO:0010629 negative regulation of gene expression
GO:0010739 positive regulation of protein kinase A signaling
GO:0010760 negative regulation of macrophage chemotaxis
GO:0019752 carboxylic acid metabolic process
GO:0030336 negative regulation of cell migration
GO:0030890 positive regulation of B cell proliferation
GO:0031982 vesicle
GO:0032760 positive regulation of tumor necrosis factor production
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034774 secretory granule lumen
GO:0035722 interleukin-12-mediated signaling pathway
GO:0042056 chemoattractant activity
GO:0042327 positive regulation of phosphorylation
GO:0042802 identical protein binding
GO:0043030 regulation of macrophage activation
GO:0043066 negative regulation of apoptotic process
GO:0043312 neutrophil degranulation
GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045087 innate immune response
GO:0048146 positive regulation of fibroblast proliferation
GO:0050178 phenylpyruvate tautomerase activity
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050900 leukocyte migration
GO:0070062 extracellular exosome
GO:0070207 protein homotrimerization
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0090344 negative regulation of cell aging
GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:1904813 ficolin-1-rich granule lumen

Subcellular Location

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Subcellular Location
Cytoplasm
Secreted

Domains

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DomainNameCategoryType
IPR001398 Macrophage migration inhibitory factorFamilyFamily
IPR014347 Tautomerase/MIF superfamilyFamilyHomologous superfamily
IPR019829 Macrophage migration inhibitory factor, conserved siteSiteConserved site

Diseases

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Drugs

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DrugNameSourceType
DB01880 3,4-Dihydroxycinnamic AcidDrugbanksmall molecule
DB02728 7-Hydroxy-2-Oxo-Chromene-3-Carboxylic Acid Ethyl EsterDrugbanksmall molecule
DB07718 4-Hydroxyphenylpyruvic acidDrugbanksmall molecule
DB07888 3-(4-HYDROXYPHENYL)-4,5-DIHYDRO-5-ISOXAZOLE-ACETIC ACID METHYL ESTERDrugbanksmall molecule
DB08333 4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIMEDrugbanksmall molecule
DB08334 3-FLUORO-4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIMEDrugbanksmall molecule
DB08335 4-HYDROXYBENZALDEHYDE O-(3,3-DIMETHYLBUTANOYL)OXIMEDrugbanksmall molecule
DB08765 6-HYDROXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDEDrugbanksmall molecule

Interactions

38 interactions

InteractorPartnerSourcesPublicationsLink
MIF_HUMANZN408_HUMANBioGRID, HPRD, IntAct15231747 details
MIF_HUMANCSN5_HUMANBioGRID, HPRD, MINT11089976 15757663 26352431 details
MIF_HUMANSTRN4_HUMANHPRD, IntAct16169070 details
MIF_HUMANGORS2_HUMANBioGRID, HPRD, IntAct16189514 details
MIF_HUMANB2L11_HUMANUniProt18677096 details
MIF_HUMANBEX3_HUMANBioGRID, IntAct21988832 details
MIF_HUMANBNIPL_HUMANBioGRID, HPRD, IntAct12681488 21988832 details
MIF_HUMANNTAQ1_HUMANBioGRID, IntAct25416956 31515488 details
MIF_HUMANMIF_HUMANBioGRID, DIP, HPRD, IntAct10353846 11170644 11997397 20534506 25416956 31515488 32296183 8610159 details
MIF_HUMANEGFR_HUMANBioGRID, DIP26280537 details
MIF_HUMANHTRA1_HUMANIntAct28726057 details
MIF_HUMANCXCR2_HUMANIntAct17435771 details
MIF_HUMANHG2A_HUMANBioGRID, HPRD12782713 details
MIF_HUMANNDKA_HUMANBioGRID, HPRD18815136 details
MIF_HUMANRENT2_HUMANBioGRID15231747 details
MIF_HUMANCSN6_HUMANHPRD, MINT15757663 details
MIF_HUMANEPB41_HUMANIntAct17353931 details
MIF_HUMANEIF1B_HUMANIntAct17353931 details
MIF_HUMANPINX1_HUMANIntAct17353931 details
MIF_HUMANTR10D_HUMANIntAct17353931 details
MIF_HUMANFBX11_HUMANIntAct17353931 details
MIF_HUMANTRM7_HUMANIntAct17353931 details
MIF_HUMANVHL_HUMANBioGRID, IntAct17353931 21942715 details
MIF_HUMANATG5_HUMANIntAct17353931 details
MIF_HUMANHLAB_HUMANIntAct17353931 details
MIF_HUMANIKKE_HUMANIntAct17353931 details
MIF_HUMANTRAF6_HUMANIntAct17353931 details
MIF_HUMANDUSTY_HUMANIntAct17353931 details
MIF_HUMANCFLAR_HUMANIntAct17353931 details
MIF_HUMANTNR14_HUMANIntAct17353931 details
MIF_HUMAN3MG_HUMANIntAct17353931 details
MIF_HUMANAAKB1_HUMANIntAct17353931 details
MIF_HUMANILK_HUMANIntAct17353931 details
MIF_HUMANCHIP_HUMANBioGRID22271573 details
MIF_HUMANHS90A_HUMANBioGRID22271573 details
MIF_HUMANP53_HUMANBioGRID, HPRD18815136 26980763 details
MIF_HUMANITA4_HUMANBioGRID22623428 details
MIF_HUMANHIF1A_HUMANBioGRID26352431 details