Entity Details

Primary name EPCAM_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP16422
EntryNameEPCAM_HUMAN
FullNameEpithelial cell adhesion molecule
TaxID9606
Evidenceevidence at protein level
Length314
SequenceStatuscomplete
DateCreated1990-08-01
DateModified2021-06-02

Ontological Relatives

GenesEPCAM

GO terms

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GOName
GO:0005886 plasma membrane
GO:0005923 bicellular tight junction
GO:0008284 positive regulation of cell population proliferation
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0016328 lateral plasma membrane
GO:0023019 signal transduction involved in regulation of gene expression
GO:0044877 protein-containing complex binding
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048863 stem cell differentiation
GO:0050900 leukocyte migration
GO:0070062 extracellular exosome
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin
GO:2000648 positive regulation of stem cell proliferation

Subcellular Location

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Subcellular Location
Cell junction
Lateral cell membrane

Domains

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DomainNameCategoryType
IPR000716 Thyroglobulin type-1DomainDomain
IPR036857 Thyroglobulin type-1 superfamilyFamilyHomologous superfamily
IPR041630 Epithelial cell adhesion molecule N-terminal domainDomainDomain
IPR043406 Transmembrane glycoprotein EPCAM/Trop-2FamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB05319 Oportuzumab monatoxDrugbankbiotech
DB05831 ING-1Drugbanksmall molecule
DB06607 CatumaxomabDrugbankbiotech
DB09336 Technetium Tc-99m nofetumomab merpentanDrugbanksmall molecule
DB11075 HypromelloseDrugbanksmall molecule