Entity Details

Primary name ATF4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP18848
EntryNameATF4_HUMAN
FullNameCyclic AMP-dependent transcription factor ATF-4
TaxID9606
Evidenceevidence at protein level
Length351
SequenceStatuscomplete
DateCreated1990-11-01
DateModified2021-06-02

Ontological Relatives

GenesATF4

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0006094 gluconeogenesis
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006366 transcription by RNA polymerase II
GO:0006874 cellular calcium ion homeostasis
GO:0007214 gamma-aminobutyric acid signaling pathway
GO:0008022 protein C-terminus binding
GO:0008140 cAMP response element binding protein binding
GO:0009636 response to toxic substance
GO:0010575 positive regulation of vascular endothelial growth factor production
GO:0010628 positive regulation of gene expression
GO:0010999 regulation of eIF2 alpha phosphorylation by heme
GO:0016607 nuclear speck
GO:0019901 protein kinase binding
GO:0030182 neuron differentiation
GO:0030282 bone mineralization
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0031667 response to nutrient levels
GO:0032057 negative regulation of translational initiation in response to stress
GO:0032590 dendrite membrane
GO:0032922 circadian regulation of gene expression
GO:0032991 protein-containing complex
GO:0034198 cellular response to amino acid starvation
GO:0034399 nuclear periphery
GO:0034599 cellular response to oxidative stress
GO:0034644 cellular response to UV
GO:0034976 response to endoplasmic reticulum stress
GO:0035162 embryonic hemopoiesis
GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress
GO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0036499 PERK-mediated unfolded protein response
GO:0042149 cellular response to glucose starvation
GO:0042789 mRNA transcription by RNA polymerase II
GO:0043005 neuron projection
GO:0043065 positive regulation of apoptotic process
GO:0043267 negative regulation of potassium ion transport
GO:0043522 leucine zipper domain binding
GO:0043525 positive regulation of neuron apoptotic process
GO:0043565 sequence-specific DNA binding
GO:0045667 regulation of osteoblast differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045943 positive regulation of transcription by RNA polymerase I
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046982 protein heterodimerization activity
GO:0048167 regulation of synaptic plasticity
GO:0061395 positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070169 positive regulation of biomineral tissue development
GO:0070309 lens fiber cell morphogenesis
GO:0070982 L-asparagine metabolic process
GO:0090650 cellular response to oxygen-glucose deprivation
GO:0120163 negative regulation of cold-induced thermogenesis
GO:0140467 integrated stress response signaling
GO:0140468 HRI-mediated signaling
GO:1903204 negative regulation of oxidative stress-induced neuron death
GO:1903351 cellular response to dopamine
GO:1905461 positive regulation of vascular associated smooth muscle cell apoptotic process
GO:1990037 Lewy body core
GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:1990589 ATF4-CREB1 transcription factor complex
GO:1990590 ATF1-ATF4 transcription factor complex
GO:1990617 CHOP-ATF4 complex
GO:1990737 response to manganese-induced endoplasmic reticulum stress
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000120 positive regulation of sodium-dependent phosphate transport

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Nucleus
Nucleus speckle

Domains

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DomainNameCategoryType
IPR004827 Basic-leucine zipper domainDomainDomain
IPR029811 cAMP-dependent transcription factor ATF-4FamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB00852 PseudoephedrineDrugbanksmall molecule

Interactions

90 interactions

InteractorPartnerSourcesPublicationsLink
ATF4_HUMANRPB3_HUMANBioGRID, HPRD, MINT12860379 details
ATF4_HUMANTRIB3_HUMANBioGRID, HPRD, IntAct12743605 18276110 20211142 25416956 25910212 32296183 details
ATF4_HUMANCC106_HUMANBioGRID, HPRD, IntAct16169070 25416956 29892012 31515488 32296183 details
ATF4_HUMANGPS2_HUMANBioGRID, HPRD, IntAct16189514 25416956 29892012 32296183 details
ATF4_HUMANLDOC1_HUMANBioGRID, HPRD, IntAct16189514 25416956 29892012 31515488 details
ATF4_HUMANHAUS7_HUMANBioGRID, HPRD, IntAct16189514 19447967 details
ATF4_HUMANPTCD3_HUMANBioGRID, HPRD, IntAct16189514 details
ATF4_HUMANTTHY_HUMANBioGRID, HPRD, IntAct16189514 29892012 31515488 details
ATF4_HUMANZHANG_HUMANBioGRID, HPIDb, MINT, UniProt16343488 20102225 23661758 details
ATF4_HUMANATF4_HUMANBioGRID, MINT, UniProt16343488 23661758 details
ATF4_HUMANDISC1_HUMANBioGRID, HPRD, IntAct12812986 31413325 details
ATF4_HUMANZN212_HUMANBioGRID, IntAct18255255 details
ATF4_HUMANIKBA_HUMANBioGRID, IntAct18255255 details
ATF4_HUMANJUN_HUMANBioGRID, HPRD, IntAct, UniProt1827203 20936779 23661758 25241761 details
ATF4_HUMANHXK3_HUMANBioGRID, IntAct21988832 details
ATF4_HUMANLMNB1_HUMANBioGRID, IntAct21988832 details
ATF4_HUMANMP2K7_HUMANBioGRID, IntAct21988832 details
ATF4_HUMANFBW1A_HUMANBioGRID, IntAct11238952 16219772 18052253 19053519 21516116 21988832 25416956 26091241 26871637 29892012 31515488 32296183 details
ATF4_HUMANMPZL2_HUMANBioGRID, IntAct21988832 details
ATF4_HUMANAPH1A_HUMANBioGRID, IntAct21988832 details
ATF4_HUMANASB7_HUMANBioGRID, IntAct21988832 details
ATF4_HUMANJUNB_HUMANBioGRID, IntAct, UniProt21988832 23661758 details
ATF4_HUMANMDM2_HUMANBioGRID, IntAct21988832 27264869 details
ATF4_HUMANRS6_HUMANBioGRID, IntAct21988832 details
ATF4_HUMANSNP29_HUMANBioGRID, IntAct21988832 26359495 details
ATF4_HUMANTGM2_HUMANBioGRID, IntAct21988832 details
ATF4_HUMANCKAP4_HUMANBioGRID, IntAct21988832 details
ATF4_HUMANREPS1_HUMANBioGRID, IntAct21988832 details
ATF4_HUMANFOS_HUMANBioGRID, HPIDb, IntAct, UniProt20102225 23661758 25241761 details
ATF4_HUMANCBP_HUMANBioGRID, IntAct10350644 11564156 25241761 9295363 details
ATF4_HUMANNDC80_HUMANBioGRID, IntAct25416956 29892012 31515488 32296183 details
ATF4_HUMANCEBPG_HUMANBioGRID, HPIDb, HPRD, IntAct, UniProt1371974 20102225 20211142 23661758 25416956 32296183 details
ATF4_HUMANGOG8F_HUMANIntAct25416956 29892012 details
ATF4_HUMANGOG8D_HUMANIntAct25416956 details
ATF4_HUMANBFSP2_HUMANBioGRID, IntAct25416956 25910212 29892012 31515488 32296183 details
ATF4_HUMANGOGA1_HUMANBioGRID, IntAct25416956 32296183 details
ATF4_HUMANGCC1_HUMANBioGRID, IntAct25416956 32296183 details
ATF4_HUMANATF3_HUMANBioGRID, DIP, HPIDb, UniProt19164757 20102225 23661758 details
ATF4_HUMANCEBPA_HUMANBioGRID, HPIDb, UniProt20102225 23661758 details
ATF4_HUMANCEBPB_HUMANHPIDb, HPRD11018027 20102225 details
ATF4_HUMANCEBPD_HUMANHPIDb20102225 details
ATF4_HUMANDDIT3_HUMANBioGRID, DIP, HPIDb, HPRD, UniProt12805554 18330356 20102225 23661758 details
ATF4_HUMANBATF_HUMANBioGRID, HPIDb, UniProt20102225 23661758 details
ATF4_HUMANMAF_HUMANBioGRID, HPIDb, UniProt20102225 23661758 details
ATF4_HUMANNF2L1_HUMANHPIDb, HPRD11025215 20102225 details
ATF4_HUMANNF2L3_HUMANHPIDb20102225 details
ATF4_HUMANSYTC2_HUMANBioGRID, IntAct32296183 details
ATF4_HUMANNP1L5_HUMANBioGRID, IntAct32296183 details
ATF4_HUMANSAPC2_HUMANBioGRID, IntAct32296183 details
ATF4_HUMANEXOC1_HUMANIntAct32296183 details
ATF4_HUMANCEP83_HUMANBioGRID, IntAct32296183 details
ATF4_HUMANAP1M1_HUMANBioGRID, IntAct32296183 details
ATF4_HUMANJDP2_HUMANBioGRID, IntAct32296183 details
ATF4_HUMANDT3UO_HUMANDIP18330356 details
ATF4_HUMANNLGN3_HUMANBioGRID, IntAct25464930 details
ATF4_HUMANNF2L2_HUMANBioGRID, HPRD, IntAct, UniProt11274184 23661758 26700459 32911434 details
ATF4_HUMANCASP6_HUMANIntAct32814053 details
ATF4_HUMANLAMP2_HUMANIntAct32814053 details
ATF4_HUMANSHLB1_HUMANIntAct32814053 details
ATF4_HUMANPR40A_HUMANIntAct32814053 details
ATF4_HUMANCEBPE_HUMANBioGRID, UniProt17042743 23661758 details
ATF4_HUMANATF2_HUMANBioGRID, UniProt23661758 details
ATF4_HUMANFOSL1_HUMANBioGRID, UniProt23661758 details
ATF4_HUMANCREB3_HUMANBioGRID, UniProt23661758 details
ATF4_HUMANBATF2_HUMANBioGRID, UniProt23661758 details
ATF4_HUMANBATF3_HUMANBioGRID, UniProt23661758 details
ATF4_HUMANMAFB_HUMANBioGRID, UniProt23661758 details
ATF4_HUMANNFE2_HUMANBioGRID, UniProt23661758 details
ATF4_HUMANTF2AY_HUMANBioGRID, IntAct20211142 details
ATF4_HUMANZN226_HUMANBioGRID, IntAct20211142 details
ATF4_HUMANTIF1A_HUMANBioGRID, IntAct20211142 details
ATF4_HUMANTREX2_HUMANBioGRID16189514 details
ATF4_HUMANTBP_HUMANBioGRID9295363 details
ATF4_HUMANT2FB_HUMANBioGRID, HPRD9295363 details
ATF4_HUMANTF2B_HUMANBioGRID9295363 details
ATF4_HUMANGABR1_HUMANBioGRID11087824 details
ATF4_HUMANGABR2_HUMANBioGRID, HPRD11087824 details
ATF4_HUMANEP300_HUMANBioGRID10350644 12471036 14630807 16219772 17872950 details
ATF4_HUMANKAT2B_HUMANBioGRID17726049 details
ATF4_HUMANFBW1B_HUMANBioGRID20724472 22017875 25332235 25515538 details
ATF4_HUMANEGLN3_HUMANBioGRID17684156 21951999 details
ATF4_HUMANA4_HUMANBioGRID21832049 details
ATF4_HUMANSRA1_HUMANBioGRID20398657 details
ATF4_HUMANNEK6_HUMANBioGRID20873783 details
ATF4_HUMANDNM3L_HUMANBioGRID24952347 details
ATF4_HUMANEGLN2_HUMANBioGRID21951999 details
ATF4_HUMANDAPK3_HUMANHPRD, UniProt21408167 9488481 details
ATF4_HUMANDAPK2_HUMANUniProt21408167 details
ATF4_HUMANEIF2A_HUMANBioGRID15475356 details
ATF4_HUMANABRX2_HUMANBioGRID30854784 details