Entity Details

Primary name E2AK2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP19525
EntryNameE2AK2_HUMAN
FullNameInterferon-induced, double-stranded RNA-activated protein kinase
TaxID9606
Evidenceevidence at protein level
Length551
SequenceStatuscomplete
DateCreated1991-02-01
DateModified2021-06-02

Ontological Relatives

GenesEIF2AK2

GO terms

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GOName
GO:0000186 obsolete activation of MAPKK activity
GO:0001819 positive regulation of cytokine production
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0006468 protein phosphorylation
GO:0008285 negative regulation of cell population proliferation
GO:0009615 response to virus
GO:0016020 membrane
GO:0017148 negative regulation of translation
GO:0019888 protein phosphatase regulator activity
GO:0030683 mitigation of host immune response by virus
GO:0032722 positive regulation of chemokine production
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0033689 negative regulation of osteoblast proliferation
GO:0034198 cellular response to amino acid starvation
GO:0035455 response to interferon-alpha
GO:0042802 identical protein binding
GO:0045071 negative regulation of viral genome replication
GO:0045087 innate immune response
GO:0046777 protein autophosphorylation
GO:0048471 perinuclear region of cytoplasm
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051607 defense response to virus
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1900225 regulation of NLRP3 inflammasome complex assembly
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1901532 regulation of hematopoietic progenitor cell differentiation
GO:1902033 regulation of hematopoietic stem cell proliferation
GO:1902036 regulation of hematopoietic stem cell differentiation

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR014720 Double-stranded RNA-binding domainDomainDomain
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR044452 EIF2AK2, first double-stranded RNA binding domainDomainDomain
IPR044453 EIF2AK2, second double-stranded RNA binding domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule

Interactions

80 interactions

InteractorPartnerSourcesPublicationsLink
E2AK2_HUMANCDC42_HUMANBioGRID, HPRD, MINT31478661 7738010 details
E2AK2_HUMANNPM_HUMANBioGRID, HPRD, MINT12882984 16957780 details
E2AK2_HUMANIF2A_HUMANBioGRID, DIP, HPRD, IntAct, MINT10542257 11985496 12882984 16288713 1677563 17290288 18971339 19364808 21368187 8099444 9431994 9819435 details
E2AK2_HUMANCDK1_HUMANMINT20395957 details
E2AK2_HUMANDHX58_HUMANBioGRID, IntAct21903422 details
E2AK2_HUMANSPB1_HUMANBioGRID, IntAct21903422 details
E2AK2_HUMANMOV10_HUMANBioGRID, IntAct21903422 details
E2AK2_HUMANPRKRA_HUMANBioGRID, DIP, HPRD, IntAct11238927 11985496 16785445 21903422 23455922 24778252 32296183 9687506 details
E2AK2_HUMANIF6_HUMANBioGRID, IntAct21903422 details
E2AK2_HUMANSTAU2_HUMANBioGRID, IntAct21903422 24778252 details
E2AK2_HUMANTOLIP_HUMANBioGRID, IntAct21903422 details
E2AK2_HUMANDHX30_HUMANBioGRID, IntAct21903422 23455922 32877691 details
E2AK2_HUMANDICER_HUMANBioGRID, IntAct21903422 details
E2AK2_HUMANTRBP2_HUMANBioGRID, HPRD, IntAct10330179 11438532 21903422 7568151 details
E2AK2_HUMANEDC4_HUMANBioGRID, IntAct21903422 details
E2AK2_HUMANZN346_HUMANBioGRID, IntAct21903422 details
E2AK2_HUMANDHX9_HUMANBioGRID, IntAct19229320 21903422 details
E2AK2_HUMANRED1_HUMANBioGRID, IntAct32296183 details
E2AK2_HUMANE2AK2_HUMANBioGRID, DIP, HPRD10848580 11337501 11447118 12882984 16373505 18082144 29070839 7568151 8887659 9528799 details
E2AK2_HUMANNLRP3_HUMANDIP22801494 details
E2AK2_HUMANSTAT1_HUMANBioGRID, HPRD11278865 9135145 details
E2AK2_HUMANPP1A_HUMANBioGRID, HPRD12138106 details
E2AK2_HUMANP53_HUMANBioGRID, HPRD10348343 10747897 10884347 19631745 details
E2AK2_HUMANILF3_HUMANBioGRID, HPRD10320367 10400669 10684936 11438536 11438540 details
E2AK2_HUMANMAP2_HUMANBioGRID, HPRD11123929 details
E2AK2_HUMANDNJC3_HUMANBioGRID, HPRD8576172 9447982 details
E2AK2_HUMAN2A5A_HUMANBioGRID, HPRD10866685 details
E2AK2_HUMANILF2_HUMANBioGRID11438540 details
E2AK2_HUMANH2A2C_HUMANBioGRID9447982 details
E2AK2_HUMANTYK2_HUMANBioGRID, HPRD17290288 details
E2AK2_HUMANEIF2A_HUMANBioGRID19229320 29070839 details
E2AK2_HUMANH2A1B_HUMANBioGRID20484669 details
E2AK2_HUMANSUMO1_HUMANBioGRID29070839 details
E2AK2_HUMANUBC9_HUMANBioGRID29070839 details
E2AK2_HUMANOGT1_HUMANBioGRID32994395 details
E2AK2_HUMANXRN2_HUMANBioGRID, IntAct21903422 29395067 details
E2AK2_HUMANSTAU1_HUMANBioGRID, IntAct21903422 29395067 30948266 details
E2AK2_HUMANPP1G_HUMANBioGRID, HPRD, IntAct12138106 21903422 details
E2AK2_HUMANHS90B_HUMANIntAct22939624 details
E2AK2_HUMANAIM2_HUMANDIP22801494 details
E2AK2_HUMANNLRP1_HUMANDIP22801494 details
E2AK2_HUMANNLRC4_HUMANDIP22801494 details
E2AK2_HUMANG3BP2_HUMANIntAct33495715 details
E2AK2_HUMANFANCC_HUMANBioGRID12397061 15299030 details
E2AK2_HUMANPKRI1_HUMANBioGRID, HPRD12679338 details
E2AK2_HUMANM3K5_HUMANBioGRID, HPRD12473108 details
E2AK2_HUMANIKKA_HUMANBioGRID, HPRD10648614 10723127 10848580 details
E2AK2_HUMANIKKB_HUMANBioGRID, HPRD10848580 details
E2AK2_HUMANPGFRB_HUMANBioGRID, HPRD11350938 details
E2AK2_HUMANSTAT3_HUMANBioGRID, HPRD11350938 details
E2AK2_HUMANMAVS_HUMANBioGRID22022264 details
E2AK2_HUMANM3K7_HUMANBioGRID, HPRD12609980 details
E2AK2_HUMANISG15_HUMANBioGRID16009940 33024031 details
E2AK2_HUMANJAK1_HUMANBioGRID, HPRD17290288 details
E2AK2_HUMANHS90A_HUMANBioGRID, HPRD11447118 22939624 details
E2AK2_HUMANTEBP_HUMANBioGRID, HPRD11447118 details
E2AK2_HUMANTRAF5_HUMANBioGRID15121867 details
E2AK2_HUMANTRAF6_HUMANBioGRID15121867 25715336 details
E2AK2_HUMANTRAF2_HUMANBioGRID15121867 25715336 details
E2AK2_HUMANMACD1_HUMANBioGRID25735744 details
E2AK2_HUMANP52K_HUMANBioGRID, HPRD20484669 8576172 details
E2AK2_HUMANPTEN_HUMANBioGRID20029030 details
E2AK2_HUMANRL6_HUMANBioGRID12882984 details
E2AK2_HUMANRLA0_HUMANBioGRID12882984 details
E2AK2_HUMANRS2_HUMANBioGRID12882984 details
E2AK2_HUMANRS3A_HUMANBioGRID12882984 details
E2AK2_HUMANLMNA_HUMANBioGRID12882984 details
E2AK2_HUMANNHLC2_HUMANBioGRID30397336 31594818 details
E2AK2_HUMANSUMO2_HUMANBioGRID29070839 details
E2AK2_HUMANCASP3_HUMANHPRD11555640 details
E2AK2_HUMANCASP7_HUMANHPRD11555640 details
E2AK2_HUMANCASP8_HUMANHPRD11555640 details
E2AK2_HUMANRAC1_HUMANHPRD7738010 details
E2AK2_HUMANTIRAP_HUMANHPRD11526399 details
E2AK2_HUMANSTRBP_HUMANHPRD10684936 details
E2AK2_HUMANTAB2_HUMANHPRD12609980 details
E2AK2_HUMANELF2_HUMANHPRD17290288 details
E2AK2_HUMANHS71A_HUMANHPRD12397061 details
E2AK2_HUMANHS71B_HUMANHPRD12397061 details
E2AK2_HUMANIKBA_HUMANHPRD10723127 8601309 9214631 9721103 details