Entity Details

Primary name RXRA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP19793
EntryNameRXRA_HUMAN
FullNameRetinoic acid receptor RXR-alpha
TaxID9606
Evidenceevidence at protein level
Length462
SequenceStatuscomplete
DateCreated1991-02-01
DateModified2021-06-02

Ontological Relatives

GenesRXRA

GO terms

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GOName
GO:0019216 regulation of lipid metabolic process
GO:0005634 nucleus
GO:0005829 cytosol
GO:0004879 nuclear receptor activity
GO:0016922 nuclear receptor binding
GO:0019899 enzyme binding
GO:0001972 retinoic acid binding
GO:0030522 intracellular receptor signaling pathway
GO:0043235 receptor complex
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0003690 double-stranded DNA binding
GO:0042277 peptide binding
GO:0050693 LBD domain binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0035357 peroxisome proliferator activated receptor signaling pathway
GO:0045893 positive regulation of transcription, DNA-templated
GO:0003700 DNA-binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0005654 nucleoplasm
GO:0015721 bile acid and bile salt transport
GO:0048856 anatomical structure development
GO:0000976 transcription cis-regulatory region binding
GO:0090575 RNA polymerase II transcription regulator complex
GO:0030851 granulocyte differentiation
GO:0042802 identical protein binding
GO:0042809 vitamin D receptor binding
GO:0005739 mitochondrion
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0030154 cell differentiation
GO:0048384 retinoic acid receptor signaling pathway
GO:1990837 sequence-specific double-stranded DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0043565 sequence-specific DNA binding
GO:0032526 response to retinoic acid
GO:0044323 retinoic acid-responsive element binding
GO:0050692 DNA binding domain binding
GO:0000785 chromatin
GO:0008270 zinc ion binding
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0008203 cholesterol metabolic process
GO:0006357 regulation of transcription by RNA polymerase II
GO:0019048 modulation by virus of host process

Subcellular Location

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Subcellular Location
Cytoplasm
Mitochondrion
Nucleus

Domains

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DomainNameCategoryType
IPR000003 Retinoid X receptor/HNF4FamilyFamily
IPR000536 Nuclear hormone receptor, ligand-binding domainDomainDomain
IPR001628 Zinc finger, nuclear hormone receptor-typeDomainDomain
IPR001723 Nuclear hormone receptorFamilyFamily
IPR013088 Zinc finger, NHR/GATA-typeFamilyHomologous superfamily
IPR021780 Nuclear/hormone receptor activator site AF-1DomainDomain
IPR035500 Nuclear hormone receptor-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00132 alpha-Linolenic acidDrugbanksmall molecule
DB00210 AdapaleneDrugbanksmall molecule
DB00307 BexaroteneDrugbanksmall molecule
DB00412 RosiglitazoneDrugbanksmall molecule
DB00459 AcitretinDrugbanksmall molecule
DB00523 AlitretinoinDrugbanksmall molecule
DB00749 EtodolacDrugbanksmall molecule
DB00755 TretinoinDrugbanksmall molecule
DB00926 EtretinateDrugbanksmall molecule
DB01393 BezafibrateDrugbanksmall molecule
DB01436 AlfacalcidolDrugbanksmall molecule
DB02746 Phthalic AcidDrugbanksmall molecule
DB03756 DoconexentDrugbanksmall molecule
DB04224 Oleic AcidDrugbanksmall molecule
DB04557 Arachidonic AcidDrugbanksmall molecule
DB05956 EVT-101Drugbanksmall molecule
DB07557 3,20-PregnanedioneDrugbanksmall molecule
DB07863 2-chloro-5-nitro-N-phenylbenzamideDrugbanksmall molecule
DB08063 1-BENZYL-3-(4-METHOXYPHENYLAMINO)-4-PHENYLPYRROLE-2,5-DIONEDrugbanksmall molecule
DB08402 2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACIDDrugbanksmall molecule
DB08601 TributyltinDrugbanksmall molecule

Interactions

135 interactions

InteractorPartnerSourcesPublicationsLink
RXRA_HUMANPNRC2_HUMANMINT11574675 details
RXRA_HUMANNCOA6_HUMANBioGRID, HPRD, IntAct10567404 10681503 10866662 11158331 11773444 14578865 details
RXRA_HUMANRARA_HUMANBioGRID, DIP, HPRD, IntAct, MINT10698945 10882070 12052862 1310351 1314167 14521715 15171703 15528208 15604093 16224062 16540467 16769902 17641689 19345331 21478865 21988832 22539306 25241761 25303530 31700049 7705655 9121466 9415406 9582446 details
RXRA_HUMANTHB_HUMANBioGRID, HPRD, MINT15604093 19211732 19422879 7746322 9162076 9171239 9368056 9415406 9582446 details
RXRA_HUMANSMAD2_HUMANBioGRID, HPRD, MINT15231748 details
RXRA_HUMANKPCD2_HUMANBioGRID, MINT15231748 details
RXRA_HUMANUBQL4_HUMANBioGRID, HPRD, IntAct16169070 details
RXRA_HUMANTMPS3_HUMANBioGRID, HPRD, IntAct16169070 details
RXRA_HUMANEDF1_HUMANBioGRID, HPRD, IntAct12040021 details
RXRA_HUMANCNOT1_HUMANBioGRID, HPRD, MINT16778766 details
RXRA_HUMANMED25_HUMANBioGRID, HPRD, MINT17641689 details
RXRA_HUMANNCOA1_HUMANBioGRID, DIP, HPRD, IntAct, MINT10082574 10454579 10517671 10935544 11027271 11124027 11438648 12612084 15140878 17363140 17673910 20682316 21478865 23602807 23975195 7481822 9121466 9171239 details
RXRA_HUMANNR1H3_HUMANBioGRID, DIP, HPRD, MINT12117567 15604093 15722453 20682316 8621574 9013544 details
RXRA_HUMANGLPK_HUMANBioGRID, IntAct21988832 details
RXRA_HUMANMCR_HUMANBioGRID, IntAct21988832 details
RXRA_HUMANSTAT1_HUMANBioGRID, IntAct21988832 details
RXRA_HUMANVDR_HUMANBioGRID, DIP, HPRD, IntAct, MINT10037600 10224118 10733574 11075811 11124027 11149488 11514567 12796488 12847098 14726489 15604093 15647825 15805579 15829977 15888456 15890193 16357103 16750418 17500032 17786964 20153625 20564192 21478865 21988832 22179700 26329759 27728806 9632709 details
RXRA_HUMANNR0B2_HUMANBioGRID, HPRD, IntAct10594021 12198243 21988832 details
RXRA_HUMANACV1B_HUMANBioGRID, IntAct21988832 details
RXRA_HUMANCASP2_HUMANBioGRID, MINT21900206 details
RXRA_HUMANCSK2B_HUMANBioGRID, MINT21900206 details
RXRA_HUMANGA45A_HUMANBioGRID, HPRD, MINT10872826 21900206 details
RXRA_HUMANGSK3B_HUMANBioGRID, MINT21900206 details
RXRA_HUMANPLK1_HUMANBioGRID, MINT21900206 details
RXRA_HUMANKS6A6_HUMANBioGRID, MINT21900206 details
RXRA_HUMANSMN_HUMANBioGRID, MINT21900206 details
RXRA_HUMANKITH_HUMANBioGRID, MINT21900206 details
RXRA_HUMANMED1_HUMANBioGRID, DIP, HPRD, UniProt10935544 11027271 11438648 15863722 21478865 9653119 details
RXRA_HUMANTF65_HUMANBioGRID, HPRD, IntAct10075655 16608838 25241761 details
RXRA_HUMANRXRA_HUMANBioGRID, HPIDb11915042 25795708 9121466 details
RXRA_HUMANPPARG_HUMANBioGRID, DIP, HPRD, IntAct, MINT10854698 10882139 11877444 12591919 12763030 12966085 14587029 15888456 16504037 17312272 17579352 17980149 18217139 19043829 19047629 19147680 20211142 21478865 21833030 22205725 22363753 23275339 23703729 23711995 25609649 26260846 30404011 30595551 30651555 30699358 31547433 7838715 9065481 9121466 9568716 details
RXRA_HUMANSQSTM_HUMANBioGRID, IntAct27684187 27728806 details
RXRA_HUMANARI5A_HUMANBioGRID, UniProt15941852 details
RXRA_HUMANNCOA2_HUMANBioGRID, DIP, HPRD10748178 11514567 11851396 11981034 12612084 15657427 17947383 21478865 24561505 9430642 details
RXRA_HUMANRAC3_HUMANDIP17947383 details
RXRA_HUMANNR1H2_HUMANBioGRID, DIP, HPRD, IntAct15604093 15722453 20211142 24561505 7760852 details
RXRA_HUMANPRGC1_HUMANBioGRID, HPRD, IntAct11714715 12522104 details
RXRA_HUMANFUS_HUMANBioGRID, HPRD, IntAct32814053 9440806 details
RXRA_HUMANBRD8_HUMANBioGRID, HPRD10517671 details
RXRA_HUMANNRBF2_HUMANBioGRID, HPRD10786636 details
RXRA_HUMANGA45G_HUMANBioGRID, HPRD10872826 details
RXRA_HUMANTDIF2_HUMANBioGRID, HPRD15047147 details
RXRA_HUMANRNF8_HUMANBioGRID, HPRD14981089 details
RXRA_HUMANNR4A1_HUMANBioGRID14980220 17761950 7705655 details
RXRA_HUMANHDAC3_HUMANBioGRID12943985 details
RXRA_HUMANHDAC4_HUMANBioGRID12943985 details
RXRA_HUMANTDG_HUMANBioGRID, HPRD12874288 details
RXRA_HUMANPML_HUMANBioGRID10610177 16540467 details
RXRA_HUMANPO2F1_HUMANBioGRID, HPRD10383413 10480874 details
RXRA_HUMANNCOA3_HUMANBioGRID, HPRD11027271 11851396 15863722 9267036 9346901 details
RXRA_HUMANMYOD1_HUMANBioGRID, HPRD9692544 details
RXRA_HUMANNRIP1_HUMANBioGRID, HPRD12549917 8887632 details
RXRA_HUMANCATL1_HUMANBioGRID, HPRD9837884 9918848 details
RXRA_HUMANTADA3_HUMANBioGRID, HPRD12235159 details
RXRA_HUMANBCL3_HUMANBioGRID, HPRD9812988 details
RXRA_HUMANNR1H4_HUMANBioGRID, HPRD19883617 7760852 details
RXRA_HUMANIKBB_HUMANBioGRID, HPRD7776974 9452433 details
RXRA_HUMANNFKB1_HUMANBioGRID, HPRD10075655 details
RXRA_HUMANTBP_HUMANBioGRID, HPRD7667283 details
RXRA_HUMANPO2F2_HUMANBioGRID10383413 details
RXRA_HUMANNR2F6_HUMANBioGRID10318855 details
RXRA_HUMANPPARA_HUMANBioGRID10195690 12562861 15888456 22205725 23711995 details
RXRA_HUMANTIF1A_HUMANBioGRID, HPRD11851396 8598193 9115274 9632676 details
RXRA_HUMANSP1_HUMANBioGRID, HPRD10361124 10393239 18270252 details
RXRA_HUMANCENPR_HUMANBioGRID, HPRD10490654 details
RXRA_HUMANNPAS2_HUMANBioGRID, HPRD11439184 details
RXRA_HUMANCLOCK_HUMANBioGRID11439184 details
RXRA_HUMANBMAL1_HUMANBioGRID11439184 details
RXRA_HUMANTHA_HUMANBioGRID, HPRD11117530 1314167 1331778 15604093 19422879 details
RXRA_HUMANNR1I3_HUMANBioGRID, HPRD12130689 15888456 19682433 8114692 details
RXRA_HUMANNR2E3_HUMANBioGRID10611353 details
RXRA_HUMANMED24_HUMANBioGRID, HPRD9653119 details
RXRA_HUMANSNW1_HUMANBioGRID11514567 details
RXRA_HUMANIBP3_HUMANBioGRID, HPRD10874028 details
RXRA_HUMANNCOR2_HUMANBioGRID, HPRD10082574 12665583 15604093 9415406 9878542 details
RXRA_HUMANTAF1B_HUMANBioGRID12511607 details
RXRA_HUMANGRIP1_HUMANBioGRID11027271 details
RXRA_HUMANNCOR1_HUMANBioGRID11124027 11903058 15116119 details
RXRA_HUMANSRC_HUMANBioGRID, HPRD15116119 15140878 details
RXRA_HUMANCTCF_HUMANBioGRID20404925 details
RXRA_HUMANMK03_HUMANBioGRID20371703 details
RXRA_HUMANMK01_HUMANBioGRID, HPRD12048211 20371703 details
RXRA_HUMANRARG_HUMANBioGRID, HPRD15604093 9083083 details
RXRA_HUMANPPARD_HUMANBioGRID, HPRD15604093 15888456 19756148 22205725 details
RXRA_HUMANNR1I2_HUMANBioGRID, HPRD15604093 22976785 23160820 26855179 9489701 9727070 details
RXRA_HUMANKIF1A_HUMANBioGRID, HPRD15604093 details
RXRA_HUMANNR4A2_HUMANBioGRID, HPRD15604093 7705655 7758108 details
RXRA_HUMANPRS8_HUMANBioGRID, HPRD7870181 8598193 8603043 details
RXRA_HUMANROBO4_HUMANBioGRID14761960 details
RXRA_HUMANARIP4_HUMANBioGRID19692572 details
RXRA_HUMANJAZF1_HUMANBioGRID15302918 details
RXRA_HUMANNCOA4_HUMANBioGRID, HPRD10347167 details
RXRA_HUMANLX15B_HUMANBioGRID15698583 details
RXRA_HUMANNSD1_HUMANBioGRID, HPRD23975195 9628876 details
RXRA_HUMANUBC9_HUMANBioGRID19692572 details
RXRA_HUMANTRIP4_HUMANBioGRID, HPRD10454579 7776974 details
RXRA_HUMANSMRD3_HUMANBioGRID, HPRD14701856 17363140 details
RXRA_HUMANSRF_HUMANBioGRID, HPRD11641790 details
RXRA_HUMANKLF5_HUMANBioGRID16224062 details
RXRA_HUMANDNM3L_HUMANBioGRID24952347 details
RXRA_HUMANSNF5_HUMANBioGRID27229929 details
RXRA_HUMANERR1_HUMANBioGRID12522104 details
RXRA_HUMANZNHI3_HUMANHPRD7776974 details
RXRA_HUMANJHD2C_HUMANHPRD7776974 details
RXRA_HUMANCIP4_HUMANHPRD7776974 details
RXRA_HUMANCSN2_HUMANHPRD7776974 details
RXRA_HUMANMECR_HUMANHPRD9795230 details
RXRA_HUMANHOP2_HUMANHPRD11739747 details
RXRA_HUMANACVR1_HUMANHPRD9267036 details
RXRA_HUMANHMGA1_HUMANHPRD10428836 details
RXRA_HUMANANM2_HUMANHPRD, IntAct12039952 details
RXRA_HUMANZN423_HUMANIntAct19345331 details
RXRA_HUMANRARB_HUMANBioGRID, HPRD, IntAct15528208 20159610 22022577 7565739 details
RXRA_HUMANP85A_HUMANBioGRID, IntAct20541701 details
RXRA_HUMANCTNB1_HUMANBioGRID, HPRD, IntAct12771132 25241761 27684187 details
RXRA_HUMANZBT16_HUMANBioGRID, HPRD, IntAct25241761 8622986 details
RXRA_HUMANBHE40_HUMANBioGRID, IntAct19786558 29234281 details
RXRA_HUMANRPB1_HUMANBioGRID15863722 details
RXRA_HUMANSMCA4_HUMANBioGRID15774904 details
RXRA_HUMANTRI32_HUMANBioGRID21984809 details
RXRA_HUMANEP300_HUMANBioGRID17761950 details
RXRA_HUMANBHE41_HUMANBioGRID19786558 details
RXRA_HUMANCHD9_HUMANBioGRID, HPRD16554032 details
RXRA_HUMANTRAF2_HUMANBioGRID25795708 details
RXRA_HUMANFGFR1_HUMANBioGRID22539306 details
RXRA_HUMANGRP75_HUMANBioGRID22022577 details
RXRA_HUMANTRAF6_HUMANBioGRID30931933 details
RXRA_HUMANESR1_HUMANBioGRID, HPRD23403292 9717844 details
RXRA_HUMANTERA_HUMANBioGRID31700049 details
RXRA_HUMANPARP1_HUMANHPRD10082530 details
RXRA_HUMANMK07_HUMANHPRD12048211 details
RXRA_HUMANTAF11_HUMANHPRD8670810 details
RXRA_HUMAN3MG_HUMANHPRD14761960 details
RXRA_HUMANGATA2_HUMANHPRD15254248 details
RXRA_HUMANCOT1_HUMANHPRD1311101 details