Entity Details

Primary name ITAX_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP20702
EntryNameITAX_HUMAN
FullNameIntegrin alpha-X
TaxID9606
Evidenceevidence at protein level
Length1163
SequenceStatuscomplete
DateCreated1991-02-01
DateModified2021-06-02

Ontological Relatives

GenesITGAX

GO terms

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GOName
GO:0005178 integrin binding
GO:0005886 plasma membrane
GO:0007155 cell adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0008284 positive regulation of cell population proliferation
GO:0008305 integrin complex
GO:0009887 animal organ morphogenesis
GO:0009986 cell surface
GO:0010628 positive regulation of gene expression
GO:0016020 membrane
GO:0019221 cytokine-mediated signaling pathway
GO:0030198 extracellular matrix organization
GO:0030335 positive regulation of cell migration
GO:0030667 secretory granule membrane
GO:0030971 receptor tyrosine kinase binding
GO:0031643 positive regulation of myelination
GO:0034113 heterotypic cell-cell adhesion
GO:0034689 integrin alphaX-beta2 complex
GO:0038023 signaling receptor activity
GO:0043312 neutrophil degranulation
GO:0045766 positive regulation of angiogenesis
GO:0046872 metal ion binding
GO:0050900 leukocyte migration
GO:0070821 tertiary granule membrane
GO:0101003 ficolin-1-rich granule membrane
GO:1905956 positive regulation of endothelial tube morphogenesis

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR000413 Integrin alpha chainFamilyFamily
IPR002035 von Willebrand factor, type ADomainDomain
IPR013517 FG-GAP repeatRepeatRepeat
IPR013519 Integrin alpha beta-propellorRepeatRepeat
IPR013649 Integrin alpha-2DomainDomain
IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved siteSiteConserved site
IPR028994 Integrin alpha, N-terminalFamilyHomologous superfamily
IPR032695 Integrin domain superfamilyFamilyHomologous superfamily
IPR036465 von Willebrand factor A-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00095 EfalizumabDrugbankbiotech