Entity Details

Primary name GPDA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP21695
EntryNameGPDA_HUMAN
FullNameGlycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic
TaxID9606
Evidenceevidence at protein level
Length349
SequenceStatuscomplete
DateCreated1991-05-01
DateModified2021-06-02

Ontological Relatives

GenesGPD1

GO terms

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GOName
GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity
GO:0004368 glycerol-3-phosphate dehydrogenase (quinone) activity
GO:0005829 cytosol
GO:0006072 glycerol-3-phosphate metabolic process
GO:0006094 gluconeogenesis
GO:0006116 NADH oxidation
GO:0006127 glycerophosphate shuttle
GO:0006654 phosphatidic acid biosynthetic process
GO:0009331 glycerol-3-phosphate dehydrogenase complex
GO:0042803 protein homodimerization activity
GO:0045821 positive regulation of glycolytic process
GO:0046168 glycerol-3-phosphate catabolic process
GO:0051287 NAD binding
GO:0070062 extracellular exosome
GO:0071320 cellular response to cAMP
GO:0071356 cellular response to tumor necrosis factor

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR006109 Glycerol-3-phosphate dehydrogenase, NAD-dependent, C-terminalDomainDomain
IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependentFamilyFamily
IPR008927 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamilyFamilyHomologous superfamily
IPR011128 Glycerol-3-phosphate dehydrogenase, NAD-dependent, N-terminalDomainDomain
IPR013328 6-phosphogluconate dehydrogenase, domain 2FamilyHomologous superfamily
IPR017751 Glycerol-3-phosphate dehydrogenase, NAD-dependent, eukaryoticFamilyFamily
IPR036291 NAD(P)-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
614480 OMIMHypertriglyceridemia, transient infantile (HTGTI)An autosomal recessive disorder characterized by onset of moderate to severe transient hypertriglyceridemia in infancy that normalizes with age. The hypertriglyceridemia is associated with hepatomegaly, moderately elevated transaminases, persistent fatty liver, and the development of hepatic fibrosis. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00157 NADHDrugbanksmall molecule
DB00331 MetforminDrugbanksmall molecule