Entity Details

Primary name ERBB3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP21860
EntryNameERBB3_HUMAN
FullNameReceptor tyrosine-protein kinase erbB-3
TaxID9606
Evidenceevidence at protein level
Length1342
SequenceStatuscomplete
DateCreated1991-05-01
DateModified2021-06-02

Ontological Relatives

GenesERBB3

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0003197 endocardial cushion development
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005524 ATP binding
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007162 negative regulation of cell adhesion
GO:0007165 signal transduction
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0007399 nervous system development
GO:0007422 peripheral nervous system development
GO:0007507 heart development
GO:0008284 positive regulation of cell population proliferation
GO:0009925 basal plasma membrane
GO:0009968 negative regulation of signal transduction
GO:0010628 positive regulation of gene expression
GO:0014037 Schwann cell differentiation
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0016328 lateral plasma membrane
GO:0019838 growth factor binding
GO:0021545 cranial nerve development
GO:0030296 protein tyrosine kinase activator activity
GO:0031625 ubiquitin protein ligase binding
GO:0033674 positive regulation of kinase activity
GO:0038128 ERBB2 signaling pathway
GO:0038131 neuregulin receptor activity
GO:0038132 neuregulin binding
GO:0038143 ERBB3:ERBB2 complex
GO:0042060 wound healing
GO:0042127 regulation of cell population proliferation
GO:0042802 identical protein binding
GO:0043125 ErbB-3 class receptor binding
GO:0043235 receptor complex
GO:0043524 negative regulation of neuron apoptotic process
GO:0046982 protein heterodimerization activity
GO:0051048 negative regulation of secretion
GO:0051402 neuron apoptotic process
GO:0051897 positive regulation of protein kinase B signaling
GO:0055025 positive regulation of cardiac muscle tissue development
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:0070886 positive regulation of calcineurin-NFAT signaling cascade
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:2000145 regulation of cell motility

Subcellular Location

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Subcellular Location
Cell membrane
Secreted

Domains

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DomainNameCategoryType
IPR000494 Receptor L-domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR006211 Furin-like cysteine-rich domainDomainDomain
IPR006212 Furin-like repeatRepeatRepeat
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR016245 Tyrosine protein kinase, EGF/ERB/XmrK receptorFamilyFamily
IPR032778 Growth factor receptor domain 4DomainDomain
IPR036941 Receptor L-domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB11652 TucatinibDrugbanksmall molecule

Interactions

220 interactions

InteractorPartnerSourcesPublicationsLink
ERBB3_HUMANSHC1_HUMANBioGRID, HPRD, IntAct, MINT11546794 16273093 16729043 22973453 24189400 24658140 8665853 9019162 9694850 9756944 details
ERBB3_HUMANGRB2_HUMANBioGRID, HPRD, IntAct, MINT11173924 16729043 24189400 24658140 9756944 details
ERBB3_HUMANP85B_HUMANBioGRID, HPRD, IntAct, MINT16273093 16729043 22973453 24189400 details
ERBB3_HUMANODF2L_HUMANBioGRID, HPRD, IntAct16169070 details
ERBB3_HUMANFWCH1_HUMANHPRD, IntAct16169070 details
ERBB3_HUMANRASL2_HUMANHPRD, IntAct16169070 details
ERBB3_HUMANTNS2_HUMANBioGRID, MINT16273093 22973453 details
ERBB3_HUMANKSYK_HUMANBioGRID, MINT16273093 22973453 details
ERBB3_HUMANRASA1_HUMANBioGRID, MINT16273093 22973453 details
ERBB3_HUMANP55G_HUMANBioGRID, IntAct, MINT16273093 22973453 24189400 details
ERBB3_HUMANP85A_HUMANBioGRID, DIP, HPRD, I2D, IntAct, MINT10383151 10572067 11389077 11546794 11694521 12896906 15812817 16273093 18803287 20007781 20227043 21075308 21278786 22439932 22973453 24189400 9130710 9756944 details
ERBB3_HUMANABL2_HUMANBioGRID, MINT16273093 22973453 details
ERBB3_HUMANGRB7_HUMANBioGRID, HPRD, IntAct, MINT16273093 22973453 24189400 9516479 details
ERBB3_HUMANDAB1_HUMANBioGRID, MINT16273093 details
ERBB3_HUMANSH21A_HUMANBioGRID, MINT16273093 22973453 details
ERBB3_HUMANTXK_HUMANBioGRID, MINT16273093 22973453 details
ERBB3_HUMANTENS3_HUMANBioGRID, MINT16273093 22973453 details
ERBB3_HUMANSRC_HUMANBioGRID, MINT16273093 22973453 details
ERBB3_HUMANSHC3_HUMANBioGRID, MINT16273093 22973453 details
ERBB3_HUMANRIN1_HUMANBioGRID, IntAct, MINT16273093 31980649 details
ERBB3_HUMANPTK6_HUMANBioGRID, HPRD, MINT11114724 16273093 22973453 details
ERBB3_HUMANPLCG1_HUMANBioGRID, MINT16273093 22973453 details
ERBB3_HUMANNCK2_HUMANBioGRID, MINT16273093 22973453 details
ERBB3_HUMANNCK1_HUMANBioGRID, MINT16273093 22973453 details
ERBB3_HUMANJAK3_HUMANBioGRID, MINT16273093 details
ERBB3_HUMANJAK2_HUMANBioGRID, MINT16273093 details
ERBB3_HUMANHCK_HUMANBioGRID, MINT16273093 22973453 details
ERBB3_HUMANCRKL_HUMANBioGRID, MINT16273093 details
ERBB3_HUMANCRK_HUMANBioGRID, MINT16273093 22973453 details
ERBB3_HUMANCHIO_HUMANBioGRID, MINT16273093 details
ERBB3_HUMANZAP70_HUMANBioGRID, MINT16273093 22973453 details
ERBB3_HUMANVAV3_HUMANBioGRID, MINT16273093 22973453 details
ERBB3_HUMANVAV2_HUMANBioGRID, MINT16273093 22973453 details
ERBB3_HUMANBCAR3_HUMANBioGRID, MINT16273093 22973453 details
ERBB3_HUMANSH2B3_HUMANBioGRID, MINT16273093 22973453 details
ERBB3_HUMANITK_HUMANBioGRID, MINT16273093 22973453 details
ERBB3_HUMANFGFR1_HUMANBioGRID, MINT16273093 details
ERBB3_HUMANFER_HUMANBioGRID, MINT16273093 22973453 details
ERBB3_HUMANDAPP1_HUMANBioGRID, MINT16273093 details
ERBB3_HUMANTENS4_HUMANBioGRID, MINT16273093 details
ERBB3_HUMANABL1_HUMANBioGRID, MINT16273093 22973453 details
ERBB3_HUMANEGFR_HUMANBioGRID, DIP, HPRD, I2D, IntAct, Molecular Connections10527633 10572067 17148612 18803307 21278786 22439932 23436906 23866081 24189400 25315821 27756321 details
ERBB3_HUMANERBB2_HUMANBioGRID, DIP, HPRD, I2D, IntAct, Molecular Connections10572067 10799311 11173924 12896906 15504738 15812817 16843263 17148612 17426253 19060928 19411071 20227043 21075308 21203579 21278786 22733765 22806884 23436906 23680147 23688700 23866081 24557338 25241761 25315821 25326665 25898135 30523157 30898150 7538656 7592681 8665853 8816440 9130710 details
ERBB3_HUMANERBB4_HUMANBioGRID, HPRD, IntAct10572067 20227043 25315821 7689552 details
ERBB3_HUMANPA2G4_HUMANBioGRID, HPRD, UniProt10682683 11325528 11708806 15583694 19037095 details
ERBB3_HUMANNRG1_HUMANBioGRID, DIP, HPRD, IntAct10913256 11389077 11555649 17697999 28988771 30523157 31467278 7592681 8702572 9168115 9565587 details
ERBB3_HUMANERBB3_HUMANBioGRID, DIP, HPRD, IntAct, UniProt10913256 12154198 20007378 21575594 23436906 24189400 25315821 8665853 8816440 details
ERBB3_HUMANHDAC6_HUMANBioGRID, IntAct20029029 31980649 details
ERBB3_HUMANS10AA_HUMANBioGRID, IntAct24189400 31980649 details
ERBB3_HUMANPTPRH_HUMANBioGRID, MINT28065597 details
ERBB3_HUMANPPM1A_HUMANBioGRID, MINT28065597 details
ERBB3_HUMANPPM1B_HUMANBioGRID, IntAct, MINT28065597 31980649 details
ERBB3_HUMANPPM1F_HUMANBioGRID, MINT28065597 details
ERBB3_HUMANPPM1K_HUMANBioGRID, MINT28065597 details
ERBB3_HUMANPPM1M_HUMANBioGRID, MINT28065597 details
ERBB3_HUMANPP2BA_HUMANMINT28065597 details
ERBB3_HUMANPTPRR_HUMANBioGRID, MINT28065597 details
ERBB3_HUMANPTN6_HUMANBioGRID, MINT22973453 28065597 details
ERBB3_HUMANPTN7_HUMANBioGRID, MINT28065597 details
ERBB3_HUMANPTN11_HUMANBioGRID, MINT22973453 28065597 9756944 details
ERBB3_HUMANPTN12_HUMANBioGRID, MINT28065597 details
ERBB3_HUMANILKAP_HUMANBioGRID, MINT28065597 details
ERBB3_HUMANMPIP3_HUMANBioGRID, MINT28065597 details
ERBB3_HUMANMTMRA_HUMANBioGRID, MINT28065597 details
ERBB3_HUMANDUS14_HUMANBioGRID, MINT28065597 details
ERBB3_HUMANEYA4_HUMANBioGRID, MINT28065597 details
ERBB3_HUMANDUS18_HUMANBioGRID, MINT28065597 details
ERBB3_HUMANDUS19_HUMANBioGRID, MINT28065597 details
ERBB3_HUMANDUS21_HUMANBioGRID, MINT28065597 details
ERBB3_HUMANDUS29_HUMANBioGRID, MINT28065597 details
ERBB3_HUMANSTYX_HUMANBioGRID, MINT28065597 details
ERBB3_HUMANPTPC1_HUMANBioGRID, MINT28065597 details
ERBB3_HUMANPTEN_HUMANBioGRID, MINT28065597 details
ERBB3_HUMANTPTE_HUMANBioGRID, MINT28065597 details
ERBB3_HUMANMTMR1_HUMANBioGRID, MINT28065597 details
ERBB3_HUMANMTMR2_HUMANBioGRID, MINT28065597 details
ERBB3_HUMANMTMR6_HUMANBioGRID, MINT28065597 details
ERBB3_HUMANMTMR9_HUMANBioGRID, MINT28065597 details
ERBB3_HUMANMTMR8_HUMANBioGRID, MINT28065597 details
ERBB3_HUMANS10A4_HUMANUniProt30083275 details
ERBB3_HUMAN1433Z_HUMANBioGRID, IntAct31980649 details
ERBB3_HUMANPGFRA_HUMANBioGRID, IntAct31980649 details
ERBB3_HUMANPLAK_HUMANBioGRID, IntAct31980649 details
ERBB3_HUMANHSP7C_HUMANBioGRID, IntAct24189400 31980649 details
ERBB3_HUMANEZRI_HUMANBioGRID, IntAct31980649 details
ERBB3_HUMANACYP1_HUMANBioGRID, IntAct31980649 details
ERBB3_HUMANALDOA_HUMANBioGRID, IntAct31980649 details
ERBB3_HUMANHS71A_HUMANBioGRID, IntAct24189400 31980649 details
ERBB3_HUMANLRRC7_HUMANIntAct31980649 details
ERBB3_HUMANATP5I_HUMANBioGRID, IntAct31980649 details
ERBB3_HUMANBEND5_HUMANBioGRID, IntAct31980649 details
ERBB3_HUMANF241B_HUMANBioGRID, IntAct31980649 details
ERBB3_HUMANLBHD1_HUMANBioGRID, IntAct31980649 details
ERBB3_HUMANERG28_HUMANBioGRID, IntAct31980649 details
ERBB3_HUMANTRIR_HUMANBioGRID, IntAct31980649 details
ERBB3_HUMANTM230_HUMANBioGRID, IntAct31980649 details
ERBB3_HUMANSIM20_HUMANBioGRID, IntAct31980649 details
ERBB3_HUMANTMA7_HUMANBioGRID, IntAct31980649 details
ERBB3_HUMANCOF1_HUMANBioGRID, IntAct31980649 details
ERBB3_HUMANENOPH_HUMANBioGRID, IntAct31980649 details
ERBB3_HUMANTV23B_HUMANBioGRID, IntAct31980649 details
ERBB3_HUMANFHL3_HUMANBioGRID, IntAct31980649 details
ERBB3_HUMANFKB1A_HUMANBioGRID, IntAct31980649 details
ERBB3_HUMANGBRL1_HUMANBioGRID, IntAct31980649 details
ERBB3_HUMANPHP14_HUMANBioGRID, IntAct31980649 details
ERBB3_HUMANPFD4_HUMANBioGRID, IntAct31980649 details
ERBB3_HUMANPFD2_HUMANBioGRID, IntAct31980649 details
ERBB3_HUMANNSE1_HUMANBioGRID, IntAct31980649 details
ERBB3_HUMANACPM_HUMANBioGRID, IntAct31980649 details
ERBB3_HUMANMYCB2_HUMANBioGRID, IntAct31980649 details
ERBB3_HUMANMYCBP_HUMANBioGRID, IntAct31980649 details
ERBB3_HUMANMAP1B_HUMANBioGRID, IntAct31980649 details
ERBB3_HUMANI2BP2_HUMANBioGRID, IntAct31980649 details
ERBB3_HUMANHINT1_HUMANBioGRID, IntAct31980649 details
ERBB3_HUMANGBRL2_HUMANBioGRID, IntAct31980649 details
ERBB3_HUMANPIN4_HUMANBioGRID, IntAct31980649 details
ERBB3_HUMANLTOR2_HUMANBioGRID, IntAct31980649 details
ERBB3_HUMANRNF41_HUMANBioGRID, HPRD, IntAct11867753 12411582 17384230 21576364 27353365 31980649 details
ERBB3_HUMANRGPA1_HUMANBioGRID, IntAct31980649 details
ERBB3_HUMANPSA5_HUMANBioGRID, IntAct31980649 details
ERBB3_HUMANRWD2A_HUMANBioGRID, IntAct31980649 details
ERBB3_HUMANSAP18_HUMANBioGRID, IntAct31980649 details
ERBB3_HUMANRTN4_HUMANBioGRID, IntAct31980649 details
ERBB3_HUMANPRDX5_HUMANBioGRID, IntAct31980649 details
ERBB3_HUMANTMG4_HUMANBioGRID, IntAct31980649 details
ERBB3_HUMANSYNEM_HUMANBioGRID, IntAct31980649 details
ERBB3_HUMANSELK_HUMANBioGRID, IntAct31980649 details
ERBB3_HUMANSF3B6_HUMANBioGRID, IntAct31980649 details
ERBB3_HUMANAP180_HUMANBioGRID, IntAct31980649 details
ERBB3_HUMANRU2B_HUMANBioGRID, IntAct31980649 details
ERBB3_HUMANZN532_HUMANBioGRID, IntAct31980649 details
ERBB3_HUMANWRIP1_HUMANBioGRID, IntAct31980649 details
ERBB3_HUMANVTA1_HUMANBioGRID, IntAct31980649 details
ERBB3_HUMANTXN4A_HUMANBioGRID, IntAct31980649 details
ERBB3_HUMANTHIO_HUMANBioGRID, IntAct31980649 details
ERBB3_HUMANTM14A_HUMANBioGRID, IntAct31980649 details
ERBB3_HUMANTM134_HUMANBioGRID, IntAct31980649 details
ERBB3_HUMANTCEA2_HUMANBioGRID, IntAct31980649 details
ERBB3_HUMANTBCA_HUMANBioGRID, IntAct31980649 details
ERBB3_HUMANARBK1_HUMANIntAct32814053 details
ERBB3_HUMANS100B_HUMANIntAct32814053 details
ERBB3_HUMANRGS4_HUMANBioGRID, HPRD12840049 details
ERBB3_HUMANEGF_HUMANBioGRID, HPRD12093292 details
ERBB3_HUMANNRG2_HUMANBioGRID, HPRD15358134 9168114 9168115 details
ERBB3_HUMANRPN1_HUMANBioGRID12840049 details
ERBB3_HUMANEGR1_HUMANBioGRID12840049 details
ERBB3_HUMANZN207_HUMANBioGRID12840049 details
ERBB3_HUMANVAV_HUMANBioGRID16273093 22973453 details
ERBB3_HUMANNEDD4_HUMANBioGRID24662824 27793840 details
ERBB3_HUMANSRPK2_HUMANBioGRID26167880 details
ERBB3_HUMANHS71B_HUMANBioGRID24189400 31980649 details
ERBB3_HUMANPTN20_HUMANBioGRID28065597 details
ERBB3_HUMANCSPG5_HUMANBioGRID15358134 details
ERBB3_HUMANKAPCA_HUMANBioGRID15914029 details
ERBB3_HUMANMUC4_HUMANBioGRID25315821 details
ERBB3_HUMANCDN2A_HUMANBioGRID22261253 details
ERBB3_HUMANARF_HUMANBioGRID22261253 details
ERBB3_HUMANAGTR2_HUMANBioGRID, HPRD10710290 details
ERBB3_HUMANCALM1_HUMANBioGRID31980649 details
ERBB3_HUMANCALM2_HUMANBioGRID31980649 details
ERBB3_HUMANCALM3_HUMANBioGRID31980649 details
ERBB3_HUMANBLK_HUMANBioGRID22973453 details
ERBB3_HUMANBLNK_HUMANBioGRID22973453 details
ERBB3_HUMANBTK_HUMANBioGRID22973453 details
ERBB3_HUMANFES_HUMANBioGRID22973453 details
ERBB3_HUMANFGR_HUMANBioGRID22973453 details
ERBB3_HUMANGRAP2_HUMANBioGRID22973453 details
ERBB3_HUMANHSH2D_HUMANBioGRID22973453 details
ERBB3_HUMANSHIP2_HUMANBioGRID22973453 details
ERBB3_HUMANLCK_HUMANBioGRID22973453 details
ERBB3_HUMANLCP2_HUMANBioGRID22973453 details
ERBB3_HUMANLYN_HUMANBioGRID22973453 details
ERBB3_HUMANMATK_HUMANBioGRID22973453 details
ERBB3_HUMANPLCG2_HUMANBioGRID22973453 details
ERBB3_HUMANSH2B1_HUMANBioGRID22973453 details
ERBB3_HUMANSH21B_HUMANBioGRID22973453 details
ERBB3_HUMANSH22A_HUMANBioGRID22973453 details
ERBB3_HUMANSH23A_HUMANBioGRID22973453 details
ERBB3_HUMANSH2D3_HUMANBioGRID22973453 details
ERBB3_HUMAN3BP2_HUMANBioGRID22973453 details
ERBB3_HUMANSHB_HUMANBioGRID22973453 details
ERBB3_HUMANSHC2_HUMANBioGRID22973453 details
ERBB3_HUMANSHC4_HUMANBioGRID22973453 details
ERBB3_HUMANSHD_HUMANBioGRID22973453 details
ERBB3_HUMANSLAP1_HUMANBioGRID22973453 details
ERBB3_HUMANSLAP2_HUMANBioGRID22973453 details
ERBB3_HUMANSOCS2_HUMANBioGRID22973453 details
ERBB3_HUMANSOCS3_HUMANBioGRID22973453 details
ERBB3_HUMANSOCS5_HUMANBioGRID22973453 details
ERBB3_HUMANSOCS6_HUMANBioGRID22973453 details
ERBB3_HUMANSTAP1_HUMANBioGRID22973453 details
ERBB3_HUMANTEC_HUMANBioGRID22973453 details
ERBB3_HUMANTENS1_HUMANBioGRID22973453 details
ERBB3_HUMANYES_HUMANBioGRID22973453 details
ERBB3_HUMANTEBP_HUMANHPRD10095121 details
ERBB3_HUMANCSK_HUMANBioGRID, MINT16729043 details
ERBB3_HUMANPK3CA_HUMANBioGRID, IntAct11546794 19411071 24189400 details
ERBB3_HUMANHS90B_HUMANBioGRID, IntAct22939624 24189400 details
ERBB3_HUMANHS90A_HUMANBioGRID, IntAct22939624 24189400 details
ERBB3_HUMANMET_HUMANBioGRID, DIP21918175 25326665 details
ERBB3_HUMANLRIG1_HUMANBioGRID, IntAct15282549 details
ERBB3_HUMANCD82_HUMANBioGRID, HPRD14576349 details
ERBB3_HUMANIL6RB_HUMANBioGRID, HPRD11821958 details
ERBB3_HUMANMUC1_HUMANBioGRID, HPRD11278868 12939402 details
ERBB3_HUMANMDM2_HUMANBioGRID21930127 details
ERBB3_HUMANAKT1_HUMANBioGRID21930127 details
ERBB3_HUMANEPN1_HUMANBioGRID26975582 details
ERBB3_HUMANL1CAM_HUMANBioGRID22815787 details
ERBB3_HUMANNED4L_HUMANBioGRID27793840 details
ERBB3_HUMANFAK2_HUMANBioGRID, HPRD15499613 27793840 details
ERBB3_HUMANNDRG1_HUMANBioGRID27793840 details
ERBB3_HUMANHGS_HUMANBioGRID28867611 details
ERBB3_HUMANPA2GA_HUMANBioGRID28440478 details
ERBB3_HUMANDOCK7_HUMANBioGRID18426980 details
ERBB3_HUMANCFLAR_HUMANBioGRID31443721 details
ERBB3_HUMANITCH_HUMANBioGRID31443721 details
ERBB3_HUMANUBP8_HUMANBioGRID31443721 details
ERBB3_HUMANSOS1_HUMANHPRD11173924 details
ERBB3_HUMANCDK5_HUMANHPRD12824184 details
ERBB3_HUMANFLNA_HUMANHPRD16729043 details