Entity Details

Primary name FGFR4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP22455
EntryNameFGFR4_HUMAN
FullNameFibroblast growth factor receptor 4
TaxID9606
Evidenceevidence at protein level
Length802
SequenceStatuscomplete
DateCreated1991-08-01
DateModified2021-06-02

Ontological Relatives

GenesFGFR4

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005007 fibroblast growth factor-activated receptor activity
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005768 endosome
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0008201 heparin binding
GO:0008284 positive regulation of cell population proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0010628 positive regulation of gene expression
GO:0010715 regulation of extracellular matrix disassembly
GO:0016477 cell migration
GO:0017134 fibroblast growth factor binding
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019216 regulation of lipid metabolic process
GO:0030133 transport vesicle
GO:0033674 positive regulation of kinase activity
GO:0042593 glucose homeostasis
GO:0042632 cholesterol homeostasis
GO:0043085 positive regulation of catalytic activity
GO:0043235 receptor complex
GO:0045862 positive regulation of proteolysis
GO:0046777 protein autophosphorylation
GO:0051897 positive regulation of protein kinase B signaling
GO:0055062 phosphate ion homeostasis
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070857 regulation of bile acid biosynthetic process
GO:2000573 positive regulation of DNA biosynthetic process

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Endoplasmic reticulum
Endosome
Secreted

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR003598 Immunoglobulin subtype 2DomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013098 Immunoglobulin I-setDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR016248 Fibroblast growth factor receptor familyFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01109 HeparinDrugbanksmall molecule
DB08901 PonatinibDrugbanksmall molecule
DB09078 LenvatinibDrugbanksmall molecule
DB12147 ErdafitinibDrugbanksmall molecule
DB15102 PemigatinibDrugbanksmall molecule

Interactions

87 interactions

InteractorPartnerSourcesPublicationsLink
FGFR4_HUMANFGF1_HUMANBioGRID, HPRD, IntAct10336501 10736564 11714710 1709094 25241761 details
FGFR4_HUMANANGL4_HUMANBioGRID, MINT25640309 details
FGFR4_HUMANBLID_HUMANBioGRID, MINT25640309 details
FGFR4_HUMANCASC3_HUMANBioGRID, MINT25640309 details
FGFR4_HUMANESIP1_HUMANBioGRID, MINT25640309 details
FGFR4_HUMANDIRA3_HUMANBioGRID, MINT25640309 details
FGFR4_HUMANERRFI_HUMANBioGRID, MINT25640309 details
FGFR4_HUMANGLCE_HUMANBioGRID, MINT25640309 details
FGFR4_HUMANLRAT2_HUMANBioGRID, MINT25640309 details
FGFR4_HUMANOSGI1_HUMANBioGRID, MINT25640309 details
FGFR4_HUMANMTA3_HUMANBioGRID, MINT25640309 details
FGFR4_HUMANPDLI2_HUMANBioGRID, MINT25640309 details
FGFR4_HUMANHOP2_HUMANBioGRID, MINT25640309 details
FGFR4_HUMANRSLAB_HUMANBioGRID, MINT25640309 details
FGFR4_HUMANBRE1A_HUMANBioGRID, MINT25640309 details
FGFR4_HUMANSG3A1_HUMANBioGRID, MINT25640309 details
FGFR4_HUMANTHRSP_HUMANBioGRID, MINT25640309 details
FGFR4_HUMANNSD3_HUMANBioGRID, MINT25640309 details
FGFR4_HUMANWIF1_HUMANBioGRID, MINT25640309 details
FGFR4_HUMANFGF19_HUMANBioGRID, DIP, HPRD10525310 19706524 details
FGFR4_HUMANPP2BA_HUMANBioGRID, MINT28065597 details
FGFR4_HUMANPTN12_HUMANBioGRID, MINT28065597 details
FGFR4_HUMANPTN6_HUMANBioGRID, MINT28065597 details
FGFR4_HUMANPTN11_HUMANBioGRID, MINT28065597 details
FGFR4_HUMANPTPRR_HUMANBioGRID, MINT28065597 details
FGFR4_HUMANFGFR4_HUMANBioGRID, HPRD10918587 28205554 8576110 details
FGFR4_HUMANERBB2_HUMANBioGRID28205554 30898150 details
FGFR4_HUMANABCB5_HUMANBioGRID28205554 details
FGFR4_HUMANARNT_HUMANBioGRID28205554 details
FGFR4_HUMANBECN1_HUMANBioGRID28205554 details
FGFR4_HUMANCCND2_HUMANBioGRID28205554 details
FGFR4_HUMANCD44_HUMANBioGRID28205554 details
FGFR4_HUMANCDK4_HUMANBioGRID28205554 details
FGFR4_HUMANCDK6_HUMANBioGRID28205554 details
FGFR4_HUMANCDN2C_HUMANBioGRID28205554 details
FGFR4_HUMANAKT1_HUMANBioGRID28205554 details
FGFR4_HUMANCDN2B_HUMANBioGRID28205554 details
FGFR4_HUMANEPHA2_HUMANBioGRID28205554 details
FGFR4_HUMANMP2K3_HUMANBioGRID28205554 28628118 details
FGFR4_HUMANFZR1_HUMANBioGRID28205554 details
FGFR4_HUMANGLIS2_HUMANBioGRID28205554 details
FGFR4_HUMANGRM1_HUMANBioGRID28205554 details
FGFR4_HUMANERD22_HUMANBioGRID28205554 details
FGFR4_HUMANLATS2_HUMANBioGRID28205554 details
FGFR4_HUMANMP2K5_HUMANBioGRID28205554 details
FGFR4_HUMANMET_HUMANBioGRID28205554 details
FGFR4_HUMANMYC_HUMANBioGRID28205554 details
FGFR4_HUMANMERL_HUMANBioGRID28205554 details
FGFR4_HUMANPGFRA_HUMANBioGRID28205554 details
FGFR4_HUMANRAF1_HUMANBioGRID28205554 details
FGFR4_HUMANRASF1_HUMANBioGRID28205554 details
FGFR4_HUMANSTK11_HUMANBioGRID28205554 details
FGFR4_HUMANTTYH2_HUMANBioGRID28205554 details
FGFR4_HUMANARAF_HUMANBioGRID28205554 details
FGFR4_HUMANCBLC_HUMANBioGRID28205554 details
FGFR4_HUMANCDN2A_HUMANBioGRID28205554 details
FGFR4_HUMANARF_HUMANBioGRID28205554 details
FGFR4_HUMANCCNE1_HUMANBioGRID28205554 details
FGFR4_HUMANHGF_HUMANBioGRID28205554 details
FGFR4_HUMANHIF1A_HUMANBioGRID28205554 details
FGFR4_HUMANIGF1R_HUMANBioGRID28205554 details
FGFR4_HUMANMP2K6_HUMANBioGRID28205554 details
FGFR4_HUMANM3K5_HUMANBioGRID28205554 details
FGFR4_HUMANMK14_HUMANBioGRID28205554 details
FGFR4_HUMANMDM4_HUMANBioGRID28205554 details
FGFR4_HUMANMSH2_HUMANBioGRID28205554 details
FGFR4_HUMANROS1_HUMANBioGRID28205554 details
FGFR4_HUMANTEAD2_HUMANBioGRID28205554 details
FGFR4_HUMANTERT_HUMANBioGRID28205554 details
FGFR4_HUMANP53_HUMANBioGRID28205554 details
FGFR4_HUMANTSC1_HUMANBioGRID28205554 details
FGFR4_HUMANFGF5_HUMANBioGRID, HPRD, IntAct25241761 8663044 details
FGFR4_HUMANMMP14_HUMANDIP20798051 details
FGFR4_HUMANEPHA4_HUMANBioGRID, HPRD16365308 details
FGFR4_HUMANKLOTB_HUMANBioGRID17623664 details
FGFR4_HUMANCADH2_HUMANHPRD9168198 details
FGFR4_HUMANSTAT3_HUMANHPRD10918587 11294897 11350938 11940572 12244095 12576423 12626508 14551213 8626374 details
FGFR4_HUMANFGF7_HUMANHPRD7680645 details
FGFR4_HUMANFGF3_HUMANHPRD8663044 details
FGFR4_HUMANFGF4_HUMANHPRD8663044 details
FGFR4_HUMANPLCG1_HUMANHPRD7518429 details
FGFR4_HUMANFGF9_HUMANHPRD8663044 details
FGFR4_HUMANFGF17_HUMANHPRD10751172 details
FGFR4_HUMANFGF2_HUMANHPRD8530375 details
FGFR4_HUMANFGF6_HUMANHPRD1385111 details
FGFR4_HUMANFGF8_HUMANHPRD10736564 details
FGFR4_HUMANSTAT1_HUMANHPRD10918587 11294897 11839738 12637327 12817007 15322115 7543024 7657660 7690989 details