Entity Details

Primary name PGH1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP23219
EntryNamePGH1_HUMAN
FullNameProstaglandin G/H synthase 1
TaxID9606
Evidenceevidence at protein level
Length599
SequenceStatuscomplete
DateCreated1991-11-01
DateModified2021-06-02

Ontological Relatives

GenesPTGS1

GO terms

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GOName
GO:0001516 prostaglandin biosynthetic process
GO:0001750 photoreceptor outer segment
GO:0004601 peroxidase activity
GO:0004666 prostaglandin-endoperoxide synthase activity
GO:0005737 cytoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0006692 prostanoid metabolic process
GO:0006954 inflammatory response
GO:0006979 response to oxidative stress
GO:0008217 regulation of blood pressure
GO:0019371 cyclooxygenase pathway
GO:0020037 heme binding
GO:0042127 regulation of cell population proliferation
GO:0043231 intracellular membrane-bounded organelle
GO:0046872 metal ion binding
GO:0051213 dioxygenase activity
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane
Microsome membrane

Domains

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DomainNameCategoryType
IPR000742 EGF-like domainDomainDomain
IPR010255 Haem peroxidase superfamilyFamilyHomologous superfamily
IPR019791 Haem peroxidase, animal-typeFamilyFamily
IPR029580 Prostaglandin G/H synthase 1FamilyFamily
IPR037120 Haem peroxidase domain superfamily, animal typeFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00035 DesmopressinDrugbanksmall molecule
DB00154 Dihomo-gamma-linolenic acidDrugbanksmall molecule
DB00159 IcosapentDrugbanksmall molecule
DB00216 EletriptanDrugbanksmall molecule
DB00244 MesalazineDrugbanksmall molecule
DB00250 DapsoneDrugbanksmall molecule
DB00313 Valproic acidDrugbanksmall molecule
DB00316 AcetaminophenDrugbanksmall molecule
DB00328 IndomethacinDrugbanksmall molecule
DB00350 MinoxidilDrugbanksmall molecule
DB00412 RosiglitazoneDrugbanksmall molecule
DB00461 NabumetoneDrugbanksmall molecule
DB00465 KetorolacDrugbanksmall molecule
DB00469 TenoxicamDrugbanksmall molecule
DB00470 DronabinolDrugbanksmall molecule
DB00471 MontelukastDrugbanksmall molecule
DB00500 TolmetinDrugbanksmall molecule
DB00533 RofecoxibDrugbanksmall molecule
DB00549 ZafirlukastDrugbanksmall molecule
DB00554 PiroxicamDrugbanksmall molecule
DB00573 FenoprofenDrugbanksmall molecule
DB00582 VoriconazoleDrugbanksmall molecule
DB00586 DiclofenacDrugbanksmall molecule
DB00605 SulindacDrugbanksmall molecule
DB00619 ImatinibDrugbanksmall molecule
DB00672 ChlorpropamideDrugbanksmall molecule
DB00711 DiethylcarbamazineDrugbanksmall molecule
DB00712 FlurbiprofenDrugbanksmall molecule
DB00731 NateglinideDrugbanksmall molecule
DB00744 ZileutonDrugbanksmall molecule
DB00749 EtodolacDrugbanksmall molecule
DB00773 EtoposideDrugbanksmall molecule
DB00784 Mefenamic acidDrugbanksmall molecule
DB00788 NaproxenDrugbanksmall molecule
DB00795 SulfasalazineDrugbanksmall molecule
DB00796 Candesartan cilexetilDrugbanksmall molecule
DB00812 PhenylbutazoneDrugbanksmall molecule
DB00814 MeloxicamDrugbanksmall molecule
DB00821 CarprofenDrugbanksmall molecule
DB00829 DiazepamDrugbanksmall molecule
DB00857 TerbinafineDrugbanksmall molecule
DB00861 DiflunisalDrugbanksmall molecule
DB00870 SuprofenDrugbanksmall molecule
DB00936 Salicylic acidDrugbanksmall molecule
DB00939 Meclofenamic acidDrugbanksmall molecule
DB00945 Acetylsalicylic acidDrugbanksmall molecule
DB00963 BromfenacDrugbanksmall molecule
DB00991 OxaprozinDrugbanksmall molecule
DB01009 KetoprofenDrugbanksmall molecule
DB01014 BalsalazideDrugbanksmall molecule
DB01029 IrbesartanDrugbanksmall molecule
DB01041 ThalidomideDrugbanksmall molecule
DB01050 IbuprofenDrugbanksmall molecule
DB01075 DiphenhydramineDrugbanksmall molecule
DB01181 IfosfamideDrugbanksmall molecule
DB01198 ZopicloneDrugbanksmall molecule
DB01221 KetamineDrugbanksmall molecule
DB01283 LumiracoxibDrugbanksmall molecule
DB01355 HexobarbitalDrugbanksmall molecule
DB01397 Magnesium salicylateDrugbanksmall molecule
DB01399 SalsalateDrugbanksmall molecule
DB01401 Choline magnesium trisalicylateDrugbanksmall molecule
DB01419 AntrafenineDrugbanksmall molecule
DB01435 AntipyrineDrugbanksmall molecule
DB01600 Tiaprofenic acidDrugbanksmall molecule
DB01837 O-acetyl-L-serineDrugbanksmall molecule
DB01892 HyperforinDrugbanksmall molecule
DB02047 (+)-2-(4-biphenyl)propionic acidDrugbanksmall molecule
DB02110 Protoporphyrin Ix Containing CoDrugbanksmall molecule
DB02198 2-Bromoacetyl GroupDrugbanksmall molecule
DB02266 Flufenamic acidDrugbanksmall molecule
DB02379 Beta-D-GlucoseDrugbanksmall molecule
DB02709 ResveratrolDrugbanksmall molecule
DB02773 (3-Chloro-4-Propoxy-Phenyl)-Acetic AcidDrugbanksmall molecule
DB03667 Acetic Acid Salicyloyl-Amino-EsterDrugbanksmall molecule
DB03752 P-(2'-Iodo-5'-Thenoyl)Hydrotropic AcidDrugbanksmall molecule
DB03753 Flurbiprofen Methyl EsterDrugbanksmall molecule
DB03783 PhenacetinDrugbanksmall molecule
DB04552 Niflumic acidDrugbanksmall molecule
DB04557 Arachidonic AcidDrugbanksmall molecule
DB04817 MetamizoleDrugbanksmall molecule
DB05109 TrabectedinSwissprotsmall molecule
DB06725 LornoxicamDrugbanksmall molecule
DB06736 AceclofenacDrugbanksmall molecule
DB06737 ZaltoprofenSwissprotsmall molecule
DB06738 KetobemidoneDrugbanksmall molecule
DB06739 SeratrodastDrugbanksmall molecule
DB06802 NepafenacDrugbanksmall molecule
DB07981 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-n-[(1R)-1-(hydroxymethyl)propyl]acetamideDrugbanksmall molecule
DB07983 1-(4-IODOBENZOYL)-5-METHOXY-2-METHYL INDOLE-3-ACETIC ACIDDrugbanksmall molecule
DB07984 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-n-[(1S)-1-(hydroxymethyl)propyl]acetamideDrugbanksmall molecule
DB08814 TriflusalDrugbanksmall molecule
DB09061 CannabidiolDrugbanksmall molecule
DB09212 LoxoprofenDrugbanksmall molecule
DB09213 DexibuprofenDrugbanksmall molecule
DB09214 DexketoprofenDrugbanksmall molecule
DB09215 DroxicamDrugbanksmall molecule
DB09216 Tolfenamic acidDrugbanksmall molecule
DB09288 PropacetamolDrugbanksmall molecule
DB09295 TalniflumateDrugbanksmall molecule
DB11071 Phenyl salicylateDrugbanksmall molecule
DB11079 Trolamine salicylateDrugbanksmall molecule
DB11201 Menthyl salicylateDrugbanksmall molecule
DB11323 Glycol salicylateDrugbanksmall molecule
DB12445 NitroaspirinDrugbanksmall molecule
DB13346 BufexamacDrugbanksmall molecule
DB13501 BendazacDrugbanksmall molecule
DB13783 AcemetacinDrugbanksmall molecule
DB13919 CandesartanDrugbanksmall molecule
DB14009 Medical CannabisDrugbankbiotech
DB14011 NabiximolsDrugbanksmall molecule