Entity Details

Primary name ITA6_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP23229
EntryNameITA6_HUMAN
FullNameIntegrin alpha-6
TaxID9606
Evidenceevidence at protein level
Length1130
SequenceStatuscomplete
DateCreated1991-11-01
DateModified2021-06-02

Ontological Relatives

GenesITGA6

GO terms

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GOName
GO:0005886 plasma membrane
GO:0005912 adherens junction
GO:0005925 focal adhesion
GO:0007044 cell-substrate junction assembly
GO:0007229 integrin-mediated signaling pathway
GO:0009986 cell surface
GO:0010668 ectodermal cell differentiation
GO:0010811 positive regulation of cell-substrate adhesion
GO:0010976 positive regulation of neuron projection development
GO:0030175 filopodium
GO:0030198 extracellular matrix organization
GO:0030199 collagen fibril organization
GO:0030335 positive regulation of cell migration
GO:0031581 hemidesmosome assembly
GO:0031589 cell-substrate adhesion
GO:0031994 insulin-like growth factor I binding
GO:0034676 integrin alpha6-beta4 complex
GO:0035878 nail development
GO:0038132 neuregulin binding
GO:0042327 positive regulation of phosphorylation
GO:0043065 positive regulation of apoptotic process
GO:0043236 laminin binding
GO:0043547 positive regulation of GTPase activity
GO:0043589 skin morphogenesis
GO:0044877 protein-containing complex binding
GO:0045296 cadherin binding
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046872 metal ion binding
GO:0050900 leukocyte migration
GO:0071407 cellular response to organic cyclic compound
GO:0098609 cell-cell adhesion
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000413 Integrin alpha chainFamilyFamily
IPR013517 FG-GAP repeatRepeatRepeat
IPR013519 Integrin alpha beta-propellorRepeatRepeat
IPR013649 Integrin alpha-2DomainDomain
IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved siteSiteConserved site
IPR028994 Integrin alpha, N-terminalFamilyHomologous superfamily
IPR032695 Integrin domain superfamilyFamilyHomologous superfamily

Diseases

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