Entity Details

Primary name PTPRZ_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP23471
EntryNamePTPRZ_HUMAN
FullNameReceptor-type tyrosine-protein phosphatase zeta
TaxID9606
Evidenceevidence at protein level
Length2315
SequenceStatuscomplete
DateCreated1991-11-01
DateModified2021-06-02

Ontological Relatives

GenesPTPRZ1

GO terms

Show/Hide Table
GOName
GO:0004725 protein tyrosine phosphatase activity
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity
GO:0005178 integrin binding
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006470 protein dephosphorylation
GO:0007417 central nervous system development
GO:0007611 learning or memory
GO:0019221 cytokine-mediated signaling pathway
GO:0031226 intrinsic component of plasma membrane
GO:0031641 regulation of myelination
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0043524 negative regulation of neuron apoptotic process
GO:0048709 oligodendrocyte differentiation
GO:0048714 positive regulation of oligodendrocyte differentiation
GO:0070445 regulation of oligodendrocyte progenitor proliferation

Subcellular Location

Show/Hide Table
Subcellular Location
Cell membrane
Secreted

Domains

Show/Hide Table
DomainNameCategoryType
IPR000242 PTP type protein phosphataseDomainDomain
IPR000387 Tyrosine specific protein phosphatases domainDomainDomain
IPR001148 Alpha carbonic anhydrase domainDomainDomain
IPR003595 Protein-tyrosine phosphatase, catalyticDomainDomain
IPR003961 Fibronectin type IIIDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR016130 Protein-tyrosine phosphatase, active siteSiteActive site
IPR029021 Protein-tyrosine phosphatase-likeFamilyHomologous superfamily
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily
IPR036398 Alpha carbonic anhydrase domain superfamilyFamilyHomologous superfamily
IPR041887 Receptor-type tyrosine-protein phosphatase, carbonic anhydrase domainDomainDomain

Diseases

Show/Hide Table