Entity Details

Primary name BDNF_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP23560
EntryNameBDNF_HUMAN
FullNameBrain-derived neurotrophic factor
TaxID9606
Evidenceevidence at protein level
Length247
SequenceStatuscomplete
DateCreated1991-11-01
DateModified2021-06-02

Ontological Relatives

GenesBDNF

GO terms

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GOName
GO:0005163 nerve growth factor receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007399 nervous system development
GO:0007411 axon guidance
GO:0007416 synapse assembly
GO:0007422 peripheral nervous system development
GO:0007613 memory
GO:0008021 synaptic vesicle
GO:0008083 growth factor activity
GO:0010832 negative regulation of myotube differentiation
GO:0010976 positive regulation of neuron projection development
GO:0016607 nuclear speck
GO:0021675 nerve development
GO:0030424 axon
GO:0030425 dendrite
GO:0031547 brain-derived neurotrophic factor receptor signaling pathway
GO:0031550 positive regulation of brain-derived neurotrophic factor receptor signaling pathway
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0038180 nerve growth factor signaling pathway
GO:0043524 negative regulation of neuron apoptotic process
GO:0045664 regulation of neuron differentiation
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048471 perinuclear region of cytoplasm
GO:0048668 collateral sprouting
GO:0048672 positive regulation of collateral sprouting
GO:0048812 neuron projection morphogenesis
GO:0050804 modulation of chemical synaptic transmission
GO:0051965 positive regulation of synapse assembly
GO:1900122 positive regulation of receptor binding
GO:1903997 positive regulation of non-membrane spanning protein tyrosine kinase activity
GO:2000008 regulation of protein localization to cell surface
GO:2001234 negative regulation of apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR002072 Nerve growth factor-relatedDomainDomain
IPR019846 Nerve growth factor conserved siteSiteConserved site
IPR020408 Nerve growth factor-likeFamilyFamily
IPR020430 Brain-derived neurotrophic factorFamilyFamily
IPR029034 Cystine-knot cytokineFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
209880 OMIMCongenital central hypoventilation syndrome (CCHS)Rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB05047 CX-717Drugbanksmall molecule
DB09130 CopperDrugbanksmall molecule
DB09301 Chondroitin sulfateDrugbanksmall molecule
DB11823 EsketamineDrugbanksmall molecule

Interactions

68 interactions

InteractorPartnerSourcesPublicationsLink
BDNF_HUMANNTF3_HUMANBioGRID, HPRD, IntAct7703225 details
BDNF_HUMANJUNB_HUMANBioGRID, IntAct21988832 details
BDNF_HUMANJAM1_HUMANBioGRID, IntAct21988832 details
BDNF_HUMANINP5K_HUMANBioGRID, IntAct21988832 details
BDNF_HUMANAGO3_HUMANBioGRID, IntAct21988832 details
BDNF_HUMANNTF4_HUMANBioGRID, IntAct10631974 25241761 29997244 details
BDNF_HUMANSORC2_HUMANbhf-ucl24908487 details
BDNF_HUMANF209A_HUMANBioGRID, IntAct32296183 details
BDNF_HUMANSORT_HUMANBioGRID, DIP, HPRD, IntAct15987945 19122660 20159974 21357693 32296183 details
BDNF_HUMANGP152_HUMANBioGRID, IntAct32296183 details
BDNF_HUMANCREB3_HUMANIntAct31515488 details
BDNF_HUMANCYH1_HUMANIntAct32814053 details
BDNF_HUMANFKBP6_HUMANIntAct32814053 details
BDNF_HUMANTHIO_HUMANIntAct32814053 details
BDNF_HUMANPRPS1_HUMANIntAct32814053 details
BDNF_HUMANKAPCA_HUMANIntAct32814053 details
BDNF_HUMANLBP_HUMANIntAct32814053 details
BDNF_HUMANHXA3_HUMANIntAct32814053 details
BDNF_HUMANFYN_HUMANIntAct32814053 details
BDNF_HUMANFUT2_HUMANIntAct32814053 details
BDNF_HUMANHYEP_HUMANIntAct32814053 details
BDNF_HUMANDNSL1_HUMANIntAct32814053 details
BDNF_HUMANCTNB1_HUMANIntAct32814053 details
BDNF_HUMANDPYL1_HUMANIntAct32814053 details
BDNF_HUMANKCC2A_HUMANIntAct32814053 details
BDNF_HUMANRM49_HUMANIntAct32814053 details
BDNF_HUMANRAGE_HUMANIntAct32814053 details
BDNF_HUMANBTBD1_HUMANIntAct32814053 details
BDNF_HUMANGALA_HUMANIntAct32814053 details
BDNF_HUMANKAD3_HUMANIntAct32814053 details
BDNF_HUMANHCST_HUMANIntAct32814053 details
BDNF_HUMANEXOC5_HUMANIntAct32814053 details
BDNF_HUMANKAT5_HUMANIntAct32814053 details
BDNF_HUMANDHRS9_HUMANIntAct32814053 details
BDNF_HUMANUBE3C_HUMANIntAct32814053 details
BDNF_HUMANSNX20_HUMANIntAct32814053 details
BDNF_HUMANMRAP2_HUMANIntAct32814053 details
BDNF_HUMANCCD32_HUMANIntAct32814053 details
BDNF_HUMANHSFY1_HUMANIntAct32814053 details
BDNF_HUMANCORO6_HUMANIntAct32814053 details
BDNF_HUMANAPH1B_HUMANIntAct32814053 details
BDNF_HUMANWDCP_HUMANIntAct32814053 details
BDNF_HUMANTLE6_HUMANIntAct32814053 details
BDNF_HUMANRUSF1_HUMANIntAct32814053 details
BDNF_HUMANGMCL2_HUMANIntAct32814053 details
BDNF_HUMANS41A3_HUMANIntAct32814053 details
BDNF_HUMANPLPR1_HUMANIntAct32814053 details
BDNF_HUMANANKH1_HUMANIntAct32814053 details
BDNF_HUMANATL4_HUMANIntAct32814053 details
BDNF_HUMANCTL5_HUMANIntAct32814053 details
BDNF_HUMANZC3H1_HUMANIntAct32814053 details
BDNF_HUMANCCD26_HUMANIntAct32814053 details
BDNF_HUMANCDK5_HUMANIntAct32814053 details
BDNF_HUMANA4_HUMANBioGRID, IntAct21832049 32814053 details
BDNF_HUMANNTRK2_HUMANBioGRID, HPRD11855816 21651720 9312147 details
BDNF_HUMANRHOU_HUMANBioGRID26598620 details
BDNF_HUMANHAP1_HUMANBioGRID21357693 details
BDNF_HUMANLRP1_HUMANBioGRID7537086 details
BDNF_HUMANDNMT1_HUMANBioGRID25476119 details
BDNF_HUMANTET1_HUMANBioGRID25476119 details
BDNF_HUMANMBD2_HUMANBioGRID25476119 details
BDNF_HUMANNCAM1_HUMANHPRD10760298 details
BDNF_HUMANESR1_HUMANHPRD11923430 details
BDNF_HUMANNOS3_HUMANHPRD10493752 details
BDNF_HUMANMBTP1_HUMANHPRD9990022 details
BDNF_HUMANCBPE_HUMANHPRD15664176 details
BDNF_HUMANBDNF_HUMANHPRD7961712 8174548 details
BDNF_HUMANCAPS2_HUMANHPRD14715936 details